Publications by authors named "Zeqi Song"
Article Synopsis
- Cordycepin, the first nucleoside antibiotic found in fungi, has various biological uses but is currently sourced inefficiently from natural fruiting bodies, leading to low yields.
- Researchers engineered a strain called YlCor-18, using metabolic engineering techniques to enable it to efficiently produce cordycepin from glucose.
- The optimized fermentation process resulted in significantly improved production levels of cordycepin, suggesting that YlCor-18 could serve as a model for sustainable production of other nucleoside antibiotics.
Cordycepin is a nucleoside antibiotic with various biological activities, which has wide applications in the area of cosmetic and medicine industries. However, the current production of cordycepin is costly and time-consuming. To construct the promising cell factory for high-level cordycepin production, firstly, the design and construction of cordycepin biosynthetic pathway were performed in Yarrowia lipolytica.
View Article and Find Full Text PDFPentostatin is a nucleoside antibiotics with a strong inhibitory effect on adenosine deaminase, and is widely used in the clinical treatment of malignant tumors. However, the high cost hampers its application. In the past 10 years, the biosynthesis of pentostatin were focused on strain breeding, optimization of medium composition and fermentation process.
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