Publications by authors named "Zentaro Yamagata"

This study aimed to investigate the relationship between allergen-specific immunoglobulin E (IgE) sensitization and allergic rhinitis (AR) symptoms in school-aged children in Japan and to understand the current severity of AR symptoms and the quality of life (QOL) among children with AR. We analyzed data from 8-year-old children who participated in the Yamanashi Adjunct Study of the Japan Environment and Children's Study, focusing on those with complete information on specific IgE levels and AR (1229 for perennial AR [PAR] and 1196 for seasonal AR [SAR]). Sensitization was determined when allergen-specific IgE levels were class 2 (0.

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This study aimed to evaluate the association between family structure and healthy life expectancy among older Japanese adults, hypothesizing that social participation increases healthy life expectancy more in older men without a spouse than in older women. This study collected data on Healthy Life Expectancy from 541 older adults between 2003 and 2021 from the Healthy Life Expectancy Study, a cohort study of older adults in Yamanashi Prefecture, Japan. The Japanese long-term care insurance system serves as an indicator of a healthy life expectancy.

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Background: In recent years, the prevalence of allergic rhinitis (AR) in Japanese children has increased significantly. Multiple sensitization and genetic factors are associated with the development of AR, and moreover, multiply sensitized children are more likely to have parents with AR. This research investigated the association of Japanese cedar pollen (JCP) sensitization in children with Dermatophagoides pteronyssinus (DP) sensitization and with maternal JCP sensitization.

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Hypertensive disorders of pregnancy (HDP) are leading causes of maternal and infant mortality, and maternal age is a known factor influencing maternal and pediatric outcomes during childbirth. This study aimed to clarify the impact of maternal age-specific blood pressure (BP) and its patterns on the risk of HDP using data from a large nationwide study in Japan. This cohort study (N = 100,949) used data from the Japan Environment and Children's Study.

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  • The study explored how gut microbiota affects non-obese individuals who consume high levels of barley, a fiber-rich food potentially beneficial for obesity prevention.
  • Researchers enrolled 185 participants, comparing those with high and low barley intake and assessing their gut bacteria and dietary habits.
  • Results showed that barley responders consumed more natto (fermented soybeans) and had higher levels of specific beneficial bacteria, suggesting enhanced fiber breakdown and butyrate production in their guts.
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  • The study investigates how genetic variations in the ADH1B and ALDH2 genes affect developmental outcomes in children based on maternal alcohol consumption during pregnancy in a Japanese population.
  • Analyzing data from 1727 mother-child pairs, it finds that children of mothers who drank alcohol during pregnancy are at a significantly higher risk for communication delays.
  • Specifically, genetic differences in the ALDH2 gene increase the risk of developmental delays, highlighting the importance of both genetic and environmental factors in child development.
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  • - The study investigated the connection between genetic variants and the necessity for glaucoma surgery among Japanese patients with primary open-angle glaucoma (POAG).
  • - A significant link was found between genetic risk scores (GRS) related to elevated intraocular pressure (IOP) and a history of glaucoma surgery, while optic nerve-related genetic variants showed no such association.
  • - Patients with a history of glaucoma surgery had higher mean GRS values for IOP-related variants compared to those without surgery, suggesting that these genetic factors are important in predicting surgical intervention.
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Objective: Continuity is considered essential for high-quality maternal and child health care services, but studies to show this effect on parental well-being are still rare. We studied whether receiving support from the same public health nurse has a beneficial effect on parental perceptions of health care professionals and the use of childcare support services.

Methods: Maternal and child health care services were provided by different nurses in a Japanese municipality until March 2019.

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  • The study assessed the link between excessive maternal weight gain during pregnancy and the risk of prolonged labor among Japanese women, focusing on a large cohort from the Japan Environment and Children's Study (JECS).
  • It found that excessive weight gain significantly increased the likelihood of prolonged labor, with a notable incidence of 10.2% in first-time mothers and 6.1% in mothers who had given birth before.
  • Analysis showed that women with excessive weight gain had longer median labor durations compared to those with normal weight gain, indicating a clear association between weight gain and complications during labor.
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Background: Currently, there is no consensus regarding the relationship between neonatal transfer and duration of hospitalization in cases of impaired mother-infant bonding (MIB). This study aimed to determine whether neonatal transfer and duration of hospitalization of newborns increase the risk for impaired MIB.

Methods: The MIB Scale was used to assess impaired MIB 1 year after delivery, using data from the Japan Environment and Children's Study.

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Background: Anterior cruciate ligament deficiency (ACL-D) causes dysfunction in the quadriceps femoris muscle, and this dysfunction hampers a safe return to sports. However, how the dysfunctional quadriceps femoris muscle affects instantaneous re-programming of motor command in response to unpredictable events remains unknown. This study aimed to examine the effects of ACL-D on re-programming of preparatory muscle activity during an unpredictable landing task.

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In Japan, physical activity duration in junior high schools is substantially higher than that in elementary schools. Using longitudinal data, this study examined the association between changes in physical activity duration and depressive symptoms in 1225 adolescents without depressive symptoms at baseline (51.2% female) from a rural city in Japan.

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Rules and ethical considerations regarding research on embryo models have been debated across numerous countries. In this paper, we provide insights from our attitude survey conducted among Japanese researchers, including members of the Japanese Society for Regenerative Medicine, and among the general public residing in Japan, the US, the UK, Canada, and Australia. Our survey revealed that many researchers expressed the need for clear guidelines for embryo model research.

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  • Women with polycystic ovary syndrome (PCOS) have a higher risk of gestational diabetes mellitus (GDM), particularly depending on their pre-pregnancy body mass index (BMI).
  • A study in Japan assessed this risk using data from nearly 93,000 singleton pregnancies, finding that women with PCOS showed increased GDM risk mainly in those with higher BMI (G4 and G5 categories).
  • The findings indicate that understanding the relationship between PCOS and BMI can help tailor preconception counseling for women at risk for GDM.
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  • The study investigates how indoor environmental factors during pregnancy influence childhood eczema in Japan, aiming to fill knowledge gaps concerning this connection.
  • Using data from the Japan Environment and Children's Study, researchers analyzed responses from over 71,000 mother-child pairs, focusing on indoor conditions and eczema symptoms in children up to 3 years old.
  • Findings revealed that higher mold levels, gas heater use, parquet flooring, and frequent insecticide application significantly increase the risk of developing eczema, suggesting a need for updated WHO guidelines on indoor air quality to better protect child health.
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Hypertensive disorders of pregnancy (HDP) increase the risk of preterm births and cesarean delivery. This study aimed to investigate whether maternal blood leukocyte, monocyte, or neutrophil counts in the first trimester are related to the development of HDP. Data were collected from the Japan Environment and Children's Study, a large birth cohort study (n = 38,194) that recruited pregnant women in 15 Regional Centers across Japan (from January 2011 to March 2014).

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  • Previous research identified swimming, atopic dermatitis, and filaggrin (FLG) gene mutations as factors increasing the risk of molluscum contagiosum (MC) infection, as FLG mutations weaken skin barrier function.
  • In this study, data from 2036 children were analyzed to assess the influence of FLG mutations on the occurrence and characteristics of MC, finding that 47.1% of children had developed MC by age 8.
  • The results indicated that FLG mutations significantly increase the risk of MC (aOR 1.69), but do not influence the number of lesions or how quickly they resolve.
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  • - The study analyzed the link between maternal intimate partner violence (IPV) before and during pregnancy and the development of autism spectrum disorder (ASD) in their 3-year-old children, using data from the Japan Environment and Children's Study.
  • - It found that among nearly 80,000 offspring, 0.45% were diagnosed with ASD, with higher rates of physical IPV reported before conception compared to during pregnancy; specifically, physical IPV prior to conception was significantly associated with an increased risk of ASD.
  • - The research highlights the importance of preventive care against physical IPV before pregnancy to support neurodevelopment in children, while indicating that psychological IPV does not show the same association with ASD development in the offspring.
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Teenage pregnancy increases the threat of depression because of its many factors. Pregnancy during young adulthood may also have several risk factors for depression compared to older pregnancies. However, data on depression in young adult pregnancies are lacking.

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  • The study investigates whether giving antibiotics to outpatients with influenza improves hospitalisation outcomes, aiming to see if it reduces the risk of hospitalisation.
  • Researchers analyzed health records from over 900,000 outpatient influenza cases to compare hospitalisation rates and lengths of stay between those given antibiotics along with anti-influenza medications and those given only antiviral treatments.
  • Findings showed that patients prescribed antibiotics had a higher hospitalisation risk and longer hospital stays for pneumonia, suggesting that antibiotics may not be beneficial in these cases.
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Background: In regions with a high prevalence of peanut allergy (PA), there is a consensus that the introduction of peanuts in early infancy is preventive against the development of PA. However, few studies have investigated whether the introduction of peanuts to infants is associated with PA in regions with a low prevalence of PA, including Japan.

Methods: We used data from 74,240 mother-child pairs who participated in the Japan Environment and Children's Study, a prospective birth cohort recruited between January 2011 and March 2014.

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Purpose: To investigate the distribution of visual acuity, refractive error, and axial length in 8-year-old children who participated in an additional survey in Yamanashi Prefecture of the Japan Environmental Children's Study (hereafter referred to as JECS-Y) conducted from 2019 to 2021.

Participants And Methods: Eight-year-old children who participated in the JECS-Y study were subjected to noncycloplegic measurements of refractive error and axial length. If the uncorrected visual acuity was less than 20/20, the best corrected visual acuity was evaluated in accordance with the autorefraction data.

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Background: Individual variation in kidney function can be affected by both congenital and acquired factors, and kidney function in children is possibly correlated with that in their mothers. However, the mother-child correlation in kidney function remains directly unconfirmed.

Methods: We conducted a cross-sectional study of 655 healthy pairs of 7- or 8-year-old children and their mothers as an adjunct study of a nationwide epidemiological study (Japan Environment and Children's Study).

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  • The study investigates the relationship between high pre-pregnancy body mass index (BMI) and the risk of stillbirth in a Japanese population, using data from a large prospective cohort of pregnant individuals.
  • Results showed that overweight and obese women had a significantly higher risk of stillbirth, with adjusted odds ratios indicating a 55% increase for overweight and a 160% increase for obese women compared to those with a normal BMI.
  • The findings highlight the importance of advising women on maintaining an appropriate pre-pregnancy BMI to reduce the risk of stillbirth.
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Background: Animal studies have shown that maternal low-fiber diets during pregnancy may impair brain development and function in offspring, but this has not been validated by epidemiological studies. The aim of this study was to investigate the link between maternal dietary fiber intake during pregnancy and neurodevelopmental delay in offspring using a large birth cohort.

Methods: A total of 76,207 mother-infant pairs were analyzed using data from the Japan Environment and Children's Study, a nationwide prospective cohort study.

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