Publications by authors named "Zenta Yamanaka"
Article Synopsis
- The study evaluated the feasibility of gasless laparoscopic myomectomy (GLM) using the subcutaneous steel wire-lifting method (GLMS) in 1301 patients from 2008 to 2021.
- Results indicated that while GLMS had longer operation times and removed more and larger fibroids compared to traditional laparoscopic myomectomy, it also had lower intraoperative blood loss and acceptable complication rates.
- The findings suggest that GLMS is a safe and effective option for fibroid removal, especially in regions with lower BMI averages, though patients with severe obesity may face higher risks.
Aim: Minimally invasive surgeries for endometrial cancer are increasing worldwide. In Japan, some articles have examined surgical outcomes, but only a few have addressed oncological outcomes. This study aims to compare robot surgery, laparoscopic surgery, and laparotomy in terms of surgical and oncological outcomes within a low-risk group for endometrial cancer recurrence.
View Article and Find Full Text PDFObjective: Hypoxia, which occurs during the development of cervical cancer, confers chemotherapy resistance. MicroRNA expression is regulated by hypoxia and is associated with the onset and progression of certain types of cancer. MicroRNA-100 (miR-100) is a microRNA, associated with nasopharyngeal and oral squamous cell carcinomas, whose expression is decreased in cervical cancer.
View Article and Find Full Text PDFEndometrial cancer is generally diagnosed at an early stage and has a good prognosis, although once it recurs, the prognosis is poor because of few therapeutic options. Since endometrial cancer has a high frequency of microsatellite instability-high/mismatch repair deficiency, the anti-PD-1 antibody pembrolizumab is expected to be one of the key therapeutic agents for recurrent endometrial cancer. Immune-related adverse events (irAEs) are autoimmune-like unique and occasionally life-threatening side effects of immune checkpoint inhibitors.
View Article and Find Full Text PDFBackground: MicroRNAs (miRNA) are promising biomarkers for cancer diagnosis and prognosis; miR-100 expression is decreased in cervical cancer tissues.
Objective: To determine whether miR-100 is a useful biomarker for early cervical cancer diagnosis.
Methods: Total RNA was extracted from the sera of 34 healthy controls (HC), 64 cervical intraepithelial neoplasia patients (CIN), and 46 cervical cancer patients (CC).