Publications by authors named "Zenon Cieslak"
Article Synopsis
- The study aimed to investigate if maternal high-dose DHA supplementation improved neurodevelopment in very preterm neonates at 18 to 22 months corrected age.
- A randomized, double-blind, placebo-controlled trial was conducted with lactating mothers of preterm neonates, comparing outcomes for children whose mothers took DHA-rich algae oil and those on a placebo.
- Results showed no overall improvement in cognitive, language, or motor scores between the two groups, but a notable benefit in language scores for neonates born before 27 weeks’ gestation who received DHA.
Health jurisdictions have seen a near-disappearance of respiratory syncytial virus (RSV) during the first year of the coronavirus disease 2019 (COVID-19) pandemic. Over this corresponding period, we report a reduction in RSV antibody levels and live virus neutralization in sera from women of childbearing age and infants between May to June 2020 and February to June 2021, in British Columbia (BC), Canada. This supports that antibody immunity against RSV is relatively short-lived and that maintaining optimal antibody levels in infants requires repeated maternal viral exposure.
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- Umbilical cord blood gas values can indicate the acid-base balance of newborns and may relate to worse outcomes in preterm infants, specifically those born before 29 weeks of gestation.
- This study analyzed data from extremely preterm neonates (23 to 28 weeks gestation) to explore the connection between umbilical cord blood gas values and mortality, as well as severe neurological injuries.
- Key findings revealed that low arterial pH (≤7.1) and base excess (≤-12 mmol/L) were linked to over a 2.5-fold increase in the likelihood of poor neonatal outcomes, including death and severe brain injuries.
Objectives: To examine rates and determinants of mother's own milk (MOM) feeding at hospital discharge in a cohort of infants born very preterm within the Canadian Neonatal Network (CNN).
Study Design: This was a population-based cohort study of infants born at <33 weeks of gestation and admitted to neonatal intensive care units (NICUs) participating in the CNN between January 1, 2015, and December 31, 2018. We examined the rates and determinants of MOM use at discharge home among the participating NICUs.
Article Synopsis
- Maternal DHA supplementation might help prevent bronchopulmonary dysplasia in premature infants, but the evidence is not clear-cut.
- A clinical trial was conducted with mothers of infants born before 29 weeks, providing them either DHA or placebo capsules; it was stopped early due to potential harm concerns.
- The results showed that 54.9% of infants who received DHA survived without bronchopulmonary dysplasia, compared to 61.6% in the placebo group, suggesting no significant benefit from DHA supplementation.
Objective: To evaluate the rates of practice, and the associations between different cord management strategies at birth (delayed cord clamping [DCC], umbilical cord milking [UCM], and early cord clamping [ECC]) and mortality or major morbidity, rates of blood transfusion, and peak serum bilirubin in a large national cohort of very preterm infants.
Study Design: We retrospectively studied preterm infants <33 weeks of gestation admitted to the Canadian Neonatal Network between January 2015 and December 2017. Patients who received ECC (<30 seconds), UCM, or DCC (≥30 seconds) were compared.
Unlabelled: : media-1vid110.1542/5984244681001PEDS-VA_2018-2286 BACKGROUND: Overuse of antibiotics can facilitate antibiotic resistance and is associated with adverse neonatal outcomes. We studied the association between duration of antibiotic therapy and short-term outcomes of very low birth weight (VLBW) (<1500 g) infants without culture-proven sepsis.
View Article and Find Full Text PDFObjectives: To evaluate the association between head growth (HG) during neonatal and postdischarge periods and neurodevelopmental outcomes of preterm neonates of <29 weeks gestational age.
Methods: We conducted a retrospective cohort study of infants <29 weeks gestational
age admitted between 2009 and 2011 to participating Canadian Neonatal Network
units and followed by Canadian Neonatal Follow-Up Network clinics. Differences in head circumference (ΔHC) z score were calculated for 3 time periods, which include admission to discharge, discharge to follow-up at 16-36 months, and admission to follow-up.
Objective: This study aims to evaluate the association between nil-per-os (NPO) days and development of necrotizing enterocolitis (NEC) in extremely preterm neonates (<29 weeks gestational age).
Study Design: A case-control study of 234 extremely preterm neonates who developed stage II or III NEC and 467 matched control infants admitted to participating sites in the Canadian Neonatal Network between 2010 and 2011 was conducted. The number and percentage of NPO days before the development of NEC was compared with the equivalent period in control infants using logistic regression.