Publications by authors named "Zeno Barcutean"
Article Synopsis
- The chaperonin TRiC/CCT is a large protein complex found in eukaryotic cells, primarily functioning in the cytosol for protein folding and complex assembly.
- Recent research uncovered TRiC/CCT's important role in the nucleus, where its inactivation increased the production of nascent RNA and led to the accumulation of noncoding transcripts.
- The study suggests that TRiC/CCT directly regulates RNA polymerase II activity, highlighting its contribution to cell homeostasis and transcription regulation.
We measure transcriptional noise in yeast by analyzing chromatin structure and transcription of an 18-kb region of DNA whose sequence was randomly generated. Nucleosomes fully occupy random-sequence DNA, but nucleosome-depleted regions (NDRs) are much less frequent, and there are fewer well-positioned nucleosomes and shorter nucleosome arrays. Steady-state levels of random-sequence RNAs are comparable to yeast mRNAs, although transcription and decay rates are higher.
View Article and Find Full Text PDF