Publications by authors named "Zengyan Yu"
Depression in youths with early life adversity: a systematic review and meta-analysis.
Front Psychiatry
September 2024
Background: Globally, early-life adversity (ELA) is linked to an increased risk of developing depression in adulthood; however, only a few studies have examined the specific effects of various types of ELA on depression in children and adolescents. This meta-analysis explores the association between the subtypes of ELA and the risk for youth-onset depression.
Methods: We searched three electronic databases for reporting types of ELA, namely, emotional abuse, physical abuse, sexual abuse, emotional neglect, physical neglect, family conflict/violence, divorce, low socioeconomic status, and left-behind experience, associated with depression before the age of 18 years.
Objectives: Depressive symptoms are the most prevalent comorbidity in individuals with obsessive-compulsive disorder (OCD). The objective of this study was to investigate the dynamic characteristics of resting-state neural activities in OCD patients with depressive symptoms.
Methods: We recruited 29 OCD patients with depressive symptoms, 21 OCD patients without depressive symptoms, and 27 healthy controls, and collected data via structural and functional magnetic resonance imaging (fMRI).
Abnormal structure and function of white matter in obsessive-compulsive disorder.
Prog Neuropsychopharmacol Biol Psychiatry
August 2024
Article Synopsis
- Abnormalities in the structure and function of gray matter in the CSTC circuit are linked to OCD, and it’s essential to study white matter characteristics to understand this condition better.
- Researchers used advanced imaging techniques on 52 OCD patients and 39 healthy controls to examine white matter structure and its functional connections, finding significant differences between the groups.
- The study revealed specific white matter changes in OCD patients, which correlated with levels of obsessive thoughts and anxiety, and these features could accurately differentiate OCD patients from healthy individuals.
Background: Obsessive-compulsive disorder (OCD) is a highly heterogeneous mental condition with a diverse symptom. Existing studies classified OCD on the basis of conventional phenomenology-based taxonomy ignoring the fact that the same subtype identified in accordance with clinical symptom may have different mechanisms and treatment responses.
Methods: This research involved 50 medicine-free patients with OCD and 50 matched healthy controls (HCs).
Article Synopsis
- This study investigated the brain structure and function in 50 medicine-free patients with obsessive-compulsive disorder (OCD) compared to 50 healthy controls, focusing on gray matter volume (GMV) and dynamic functional connectivity (dFC) at rest.
- Results showed that patients with OCD had reduced GMV in specific brain areas, such as the left superior temporal gyrus (STG) and right supplementary motor area (SMA), along with decreased dFC between these regions and other brain areas.
- The findings suggest that these alterations in GMV and dFC could be important for understanding the mechanisms of OCD, and multimodal imaging data could effectively distinguish OCD from healthy individuals with high accuracy.*
Functional abnormalities in brain areas within the fronto-limbic network have been widely reported in obsessive-compulsive disorder (OCD). However, region- and network-level brain activities of the fronto-limbic network at rest have not been simultaneously investigated in OCD. In this study, 40 medicine-free and non-comorbidity patients with OCD and 38 age-, education-, and gender-matched healthy controls (HCs) underwent a resting-state functional magnetic-resonance-imaging scan.
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