Publications by authors named "Zengshi Li"
Glioblastoma stem cells (GSCs) have been implicated in the self-renewal and treatment resistance of glioblastoma (GBM). Our previous study found that 4,5-dimethoxycanthin-6-one has the potential to inhibit GBM cell proliferation. This current study aims to elucidate the molecular mechanism underlying the effects of 4,5-dimethoxycanthin-6-one in GBM development.
View Article and Find Full Text PDFmiR-374a-5p expression and localization in intracranial aneurysm (IA) tissues were detected, and its correlation with vascular smooth muscle cells (VSMCs) and macrophage markers was analyzed. Using platelet-derived growth factor-BB (PDGF-BB) induced VSMC model, elastase-induced IA rat model. Subsequently, miR-374a-5p was knocked down or overexpressed.
View Article and Find Full Text PDFBackground: Hypertensive intracerebral hemorrhage (HICH) is a life-threatening disease and lacks effective treatments. Previous studies have confirmed that metabolic profiles altered after ischemic stroke, but how brain metabolism changes after HICH was unclear. This study aimed to explore the metabolic profiles after HICH and the therapeutic effects of soyasaponin I on HICH.
View Article and Find Full Text PDFArticle Synopsis
- - The study investigates the connection between gut microbiota, inflammation, and hypertensive intracerebral hemorrhage (HICH), which is becoming more common and is linked to high mortality and morbidity rates.
- - Researchers found that patients with HICH showed increased levels of inflammatory markers in blood and brain, decreased diversity in gut microbiota, and changes in metabolic profiles related to caffeine metabolism.
- - The findings suggest that specific gut bacteria are associated with inflammation levels, which may help in diagnosing and treating HICH effectively.