PNO1 promotes the progression of osteosarcoma via TGF-β and YAP/TAZ pathway.

This study aimed to explore the potential role and mechanisms of the partner of NOB1 homolog (PNO1) in osteosarcoma. The expression of PNO1 in tumor and adjacent tissue samples was examined using western blotting. Lentiviral transfection was used to establish sh-Ctrl and sh-PNO1 osteosarcoma cell lines.

Identification of Prognostic RBPs in Osteosarcoma.

Osteosarcoma often occurs in children and adolescents and causes poor prognosis. The role of RNA-binding proteins (RBPs) in malignant tumors has been elucidated in recent years. Our study aims to identify key RBPs in osteosarcoma that could be prognostic factors and treatment targets.

Effects of circadian rhythm disorder on body composition in women aged 31-40 years.

Background: Circadian rhythm disorder caused by lack of sleep, day-night reversal, or staying up late, can cause irreparable damage to the body, a significant increase in both the systolic and diastolic blood pressure of women in this age bracket. The purpose of this study was to investigate the effects of circadian disruption on body composition and insulin resistance in women aged 31-40 years.

Methods: Thirty female with circadian rhythm disorder and employed of the Foot Bath Club in Qufu city were selected as the research subjects, and a body composition analyzer was used to test the subjects' body composition using bioelectrical impedance analysis.