The Regulation of Cerebral Lymphatic Drainage in the Transverse Sinus Region of the Mouse Brain.

Cerebral lymphatic drainage is an important pathway for metabolic waste clearance in the brain, which plays a crucial role in the progression of central nervous system diseases. Recent studies have shown that norepinephrine (NE) is involved in the regulation of cerebral lymphatic drainage function, but the modulation mechanism remains unknown. In this study, we confirmed that NE rapidly reduced glymphatic influx and enhanced meningeal lymphatic clearance.

Tanshinone IIA inhibits osteosarcoma growth through modulation of AMPK-Nrf2 signaling pathway.

Tanshinone IIA (Tan IIA) is a member of the major lipophilic components extracted from the root of Bunge. Osteosarcomas are primary malignant tumors of bone. The aim of our study is to explore the role of Tan IIA in osteosarcomas survival, migration, and proliferation.