Legacy and emerging organophosphate flame retardants (OPFRs) in water and sediment from the Pearl River Delta to the adjacent coastal waters of the South China Sea: Spatioseasonal variations, flux estimation and ecological risk.

The industrialization and urbanization along the Pearl River Delta (PRD) have exacerbated the issue of pollution in aquatic environments by organophosphate flame retardants (OPFRs). Historical cumulative pollution from legacy OPFRs, combined with newly emerging OPFRs, has increased the severity and complexity of OPFR pollution in this region. We explored the contamination profile, input flux and risk of legacy and emerging OPFRs in surface waters and in sediment samples of the PRD.

Human toxicity of polybrominated diphenyl ethers (PBDEs) and their derivatives: A comprehensive review.

Polybrominated biphenyl ethers (PBDEs) have been pervasively used as an additive flame retardant in various fields. The nature of environmental persistence, bioaccumulation, and potential toxicity attracted attention worldwide and became a threat to both the ecosystem and human health. Originally, PBDEs are produced in chemical factories.

Chronic Real-Ambient PM Exposure Exacerbates Cardiovascular Risk via Amplifying Liver Injury in Mice Fed with a High-Fat and High-Cholesterol Diet.

Epidemiology has associated fine particulate matter (PM) exposure with an increased cardiovascular risk. However, the underlying mechanism, particularly from the liver perspective, remains unclear. Here, the influence of chronic PM exposure on cardiovascular risk in mice fed a high-fat and high-cholesterol diet (HFCD) was studied by using a real-world PM exposure system.

Polybrominated diphenyl ethers and their alternatives in soil cores from a typical flame-retardant production park: Vertical distribution and potential influencing factors.

With the prohibition on the production and use of polybrominated diphenyl ethers (PBDEs), decabromodiphenyl ethane (DBDPE) and organophosphate flame retardants (OPFRs) have emerged as their alternatives. However, the vertical transport and associated influencing factors of these chemicals into soil are not clearly understood. To clarify the vertical distribution of the pollutants and related influencing factors, surface soil and soil core samples were collected at a depth in the range of 0.

Nontarget Analysis of Legacy and Emerging PFAS in a Lithium-Ion Power Battery Recycling Park and Their Possible Toxicity Measured Using High-Throughput Phenotype Screening.

Driven by the global popularity of electric vehicles and the shortage of critical raw materials for batteries, the spent lithium-ion power battery (LIPB) recycling industry has exhibited explosive growth in both quantity and scale. However, relatively little information is known about the environmental risks posed by LIPB recycling, in particular with regards to perfluoroalkyl and polyfluoroalkyl substances (PFAS). In this work, suspect screening and nontarget analysis were carried out to characterize PFAS in soil, dust, water and sediment from a LIPB recycling area.

Phosphocholine-induced energy source shift alleviates mitochondrial dysfunction in lung cells caused by geospecific PM components.

Fine particulate matter (PM) is globally recognized for its adverse implications on human health. Yet, remain limited the individual contribution of particular PM components to its toxicity, especially considering regional disparities. Moreover, prevention solutions for PM-associated health effects are scarce.

A large-scale survey of urinary parabens and triclocarban in the Chinese population as well as the influencing factors and health risks.

Parabens and triclocarban are widely applied as antimicrobial preservatives in foodstuffs, pharmaceuticals, cosmetics, and personal care products. However, few studies have been conducted on large-scale biomonitoring of parabens and triclocarban in the Chinese general population. In the present study, there were 1157 urine samples collected from 26 Chinese provincial capitals for parabens and triclocarban measurement to evaluate the exposure levels, spatial distribution, and influencing factors, as well as associated health risks in the Chinese population.

A combined study of skin penetration by confocal Raman spectroscopy and human metabolism: A case of benzophenone-3 in sunscreen.

Although numerous experiments on benzophenone-3 (BP3) have shown that it can permeate into the skin, the in vivo penetration situation and urinary metabolic trend have not yet been investigated. In this study, sunscreen containing 5.72% BP3 was selected for human-skin exposure.

Co-precipitation of Cd with struvite during phosphorus recovery.

During the struvite recovery process, Cd, a hazardous metal commonly found in waste streams, can be sequestered by struvite. This study investigated the influence of Cd on the precipitation of struvite. Quantitative X-ray diffraction (QXRD) results showed that the purity of struvite decreased from 99.

Emission characteristics of (halogenated) polycyclic aromatic hydrocarbons during printed circuit board combustion and estimated emission intensity of a typical e-waste dismantling site in South China.

The pollution of polycyclic aromatic hydrocarbons (PAHs) and halogenated PAHs (Cl/Br-PAHs) caused by electronic waste dismantling activities have attracted considerable attention. The present study investigated the emissions and formation of PAHs and Cl/Br-PAHs based on the combustion of printed circuit boards simulating electronic waste dismantling process. The emission factor of ΣPAHs was 648 ± 56 ng/g, which was much lower than that of ΣCl/Br-PAHs (8.

A large-scale nationwide study of urinary phenols in the Chinese population.

Bisphenol A (BPA), tetrabromobisphenol A (TBBPA), and their substitutes are commonly used in everyday products. However, large-scale internal exposure levels of them in China, the factors influencing on them, and the associated health risks were not systematically investigated still. In the present study, there were 1157 morning urine samples collected from residents of 26 provincial capitals in China for the measurement of BPA and seven bisphenol analogues, as well as TBBPA and its substitutes, i.

Estimation of indoor soil/dust-skin adherence factors and health risks for adults and children in two typical cities in southern China.

Soil/dust (SD) skin adherence is key dermal exposure parameter used for calculating the health risk of dermal exposure to contaminants. However, few studies of this parameter have been conducted in Chinese populations. In this study, forearm SD samples were randomly collected using the wipe method from population in two typical cities in southern China as well as office staff in a fixed indoor environment.

Xanthine-derived reactive oxygen species exacerbates adipose tissue disorders in male db/db mice induced by real-ambient PM2.5 exposure.

Epidemiological and experimental data have associated exposure to fine particulate matter (PM2.5) with various metabolic dysfunctions and diseases, including overweight and type 2 diabetes. Adipose tissue is an energy pool for storing lipids, a necessary regulator of glucose homeostasis, and an active endocrine organ, playing an essential role in developing various related diseases such as diabetes and obesity.

DEHP exposure elevated cardiovascular risk in obese mice by disturbing the arachidonic acid metabolism of gut microbiota.

Phthalate esters (PAEs) are one of the significant classes of emerging contaminants that are increasingly detected in environmental and human samples. Nevertheless, the current toxicity studies rarely report how PAEs affect the cardiovascular system, especially in obese individuals. In this study, diet-induced obese mice and corresponding normal mice were exposed to di(2-ethylhexyl) phthalate (DEHP) by oral gavage at environmentally relevant concentrations and key characteristics of cardiovascular risk were examined.

Proliferation toxicity and mechanism of novel mixed bromine/chlorine transformation products of tetrabromobisphenol A on human embryonic stem cell.

Mixed bromine/chlorine transformation products of tetrabromobisphenol A (ClBrBPAs) are mixed halogenated-type compounds recently identified in electronic waste dismantling sites. There are a lack of toxicity data on these compounds. To study their development toxicity, the proliferation toxicity was investigated using human embryonic stem cells (hESC) exposed to the lowest effective dose of two ClBrBPA analogues (2-chloro-2',6-dibromobisphenol A and 2,2'-dichloro-6-monobromobisphenol A).

Associated long-term effects of decabromodiphenyl ethane on the gut microbial profiles and metabolic homeostasis in Sprague-Dawley rat offspring.

Decabromodiphenyl ethane (DBDPE) as a widely used brominated flame retardant is harmful to human health due to its toxicity, including cardiovascular toxicity, reproductive toxicity, and hepatotoxicity. However, the knowledge of the long-term effects and structural and metabolic function influence on gut microbiota from DBDPE exposure remains limited. This study was mainly aimed at the gut microbiome and fecal metabolome of female rats and their offspring exposed to DBDPE in early life.

A Novel Strategy to Directly Quantify Polyethylene Microplastics in PM Based on Pyrolysis-Gas Chromatography-Tandem Mass Spectrometry.

The broad application of plastic products has resulted in a considerable release of microplastics (MPs) into the ecosystem. While MPs in other environmental matrices (e.g.

Contribution and Effects of PM-Bound Lead to the Cardiovascular Risk of Workers in a Non-Ferrous Metal Smelting Area Considering Chemical Speciation and Bioavailability.

Lead is known to have toxic effects on the cardiovascular system. Owing to its high concentration, transmission range, and absorption efficiency in organisms, inhalation of fine particulate matter (PM)-bound lead (PM-Pb) may cause significant cardiovascular damage. However, the contribution and adverse effects of PM-Pb on workers and residents in non-ferrous metal smelting areas are not fully understood.

Temporal trends and health risks of organophosphorus flame retardants in fishes in Taihu Lake from 2013 to 2018.

Organophosphorus flame retardants (OPFRs) are synthetic, physical additive flame retardants widely detected in the environment. To investigate the temporal trends of OPFRs in Taihu regions and the associated health risks from fish consumption, 150 fish samples of five species were collected from Taihu Lake in China from 2013 to 2018. Eight OPFRs were measured, having 2-ethylhexyl diphenyl phosphate (90.

Azole-Induced Color Vision Deficiency Associated with Thyroid Hormone Signaling: An Integrated , , and Study.

Azoles that are used in pesticides, pharmaceuticals, and personal care products can have toxic effects on fish. However, there is no information regarding azole-induced visual disorder associated with thyroid disruption. We evaluated changes in retinal morphology, optokinetic response, transcript abundance of the genes involved in color perception and hypothalamic-pituitary-thyroid (HPT) axis, and thyroid hormone (TH) levels in zebrafish larvae exposed to common azoles, such as climbazole (CBZ, 0.