Publications by authors named "Zenghua Jiang"
Article Synopsis
- - Colorectal cancer (CRC) progresses through stages from normal cells to adenomas and then to invasive cancer, involving various molecular changes, including extrachromosomal circular DNAs (ecDNAs), although their exact roles in CRC are not fully understood.
- - Researchers used Circle-Sequencing and whole transcriptomic sequencing to analyze circular DNAs and transcriptomes in healthy individuals and patients with adenomas and CRC, revealing that specific circular DNAs influence oncogene expression and are linked to immune response and cell cycle pathways.
- - Among the findings, chr8 showed significant up-regulation during CRC progression and was associated with poor prognosis in a separate cohort, suggesting it could serve as a valuable biomarker and potential therapeutic target for CRC treatment
