Risk factors for postoperative recurrence after full-endoscopic microvascular decompression for trigeminal neuralgia: a retrospective study and predictive nomogram.

Background: Full-endoscopic microvascular decompression (fE-MVD) is an emerging treatment option for trigeminal neuralgia (TN). However, the risk factors associated with postoperative recurrence of TN after fE-MVD procedure remain controversial. The aim of the present study was to summarize the surgical technique of fE-MVD for the treatment of TN and to develop a predictive model for recurrence at 1 year postoperatively based on independent risk factors.

[Somatic symptoms often comorbid with benign anorectal disorders: a study of their significance].

Benign anorectal diseases represent a prevalent and intricate category of gastrointestinal disorders, encompassing conditions such as anal fissures, fistulas, hemorrhoids, incontinence, pain, and defecation disorders. These conditions include both anatomical abnormalities and functional disorders. Some patients continue to experience discomfort such as perianal discomfort, perineal heaviness, defecation difficulties, and abdominal bloating even after anatomical issues have been addressed, severely impairing social functioning.

The safety, pharmacokinetics and neutralizing activity of recombinant human anti-rabies monoclonal antibody NM57 injection (rhRIG, Ormutivimab) in combination with rabies vaccination in Chinese healthy adults: A phase Ib randomized, double-blind, parallel-controlled clinical study.

Background: The combination of passive immune agents (human rabies immune globulin (HRIG) and equine rabies antiserum (ERA)) with vaccines are effective measures for preventing the onset of rabies post exposure. However, ERA and HRIG have potential risks of serum allergic reactions and blood-transmitted infectious diseases. This study compared the safety, pharmacokinetics and neutralizing activity of recombinant human anti-rabies monoclonal antibody NM57 injection (rhRIG, Ormutivimab) and HRIG in combination with rabies vaccine and vaccine alone.

Cysteine-induced disulfide cleavage enhances the solubility of alkali-treated pea protein and its elasticity contribution in low-salt hybrid meat gels.

This study investigated the effectiveness of cysteine in improving the functional properties of pea proteins within low-salt myofibrillar protein (MP) gels. Cysteine treatment, at a concentration of 3.3 mM/g protein, cleaved 71-82 % of the disulfide bonds in native and pH-shifted pea protein isolates (PPI and PPI), which increased the solubility and hydrophobicity of PPI.

Deciphering endocrine function of adipose tissue and its significant influences in obesity-related diseases caused by its dysfunction.

Current research has found that adipose tissue is not only involved in energy metabolism, but also a highly active endocrine organ that secretes various adipokines, including adiponectin, leptin, resistin and apelin, which are involved in the regulation of physiology and pathology of tissues and organs throughout the body. With the yearly increasing incidence, obesity has become a risk factor for a variety of pathological changes, including inflammation and metabolic syndrome in various system (endocrine, circulatory, locomotor and central nervous system). Thus these symptoms lead to multi-organ dysfunctions, including the heart, liver, kidneys, brain and joints.

A simply designed quasi-ratiometric fluorescence probe for the visual and on-site detection of levofloxacin (LVF) residues in milk and fish sample.

An europium metal organic framework (Eu-DBPA-Phen) was synthesized using 2,5-dibromoterephthalic acid (HDBPA) and 1-10-phenanthroline (Phen) as ligands. A straightforwardc quasi-ratiometric fluorescence probe was then developed for the detection of levofloxacin (LVF) by the simplistic combination of red-emitting Eu-DBPA-Phen and the inherent blue auto-fluorescence of the target. The probe exhibits the advantages of wide linear range (0.

Mechanistic insights into carbonate radical-driven reactions: Selectivity and the hydrogen atom abstraction route.

Carbonate radical (CO) is inevitably produced in advanced oxidation processes (AOPs) when addressing real-world aqueous environments, yet it often goes unnoticed due to its relatively lower reactivity. In this study, we emphasized the pivotal role of CO in targeting the elimination of contaminants by contrasting it with conventional reactive oxygen species (ROSs) and assessing the removal of sulfamethazine (SMT). Similar to singlet oxygen (O), CO shows a preference for electron-rich organic compounds.

Intensive electron transfer of a single-atom Fe-based catalytic ceramic membrane for municipal wastewater treatment: The synergistic effects of nitrogen vacancy defect and ultrathin nanostructure.

The integration of membrane separation with heterogeneous advanced oxidation processes is a prospective strategy for the elimination of contaminants during wastewater treatment. Fe-based catalysts and the green oxidant peracetic acid (PAA) are desirable candidates for the development of catalytic membranes because they are environmentally friendly. However, the construction of catalytic ceramic membranes (CMs) modified with efficient Fe-based catalysts that generate increased amounts of high-valent Fe-O species during PAA activation for the degradation of specific pollutants, especially during instantaneous membrane filtration, remains challenging.

Semaglutide protects against diabetes-associated cardiac inflammation via Sirt3-dependent RKIP pathway.

Background And Purpose: Glucagon-like peptide-1 receptor agonists (GLP-1RAs) exert cardiovascular benefits in diabetic patients, but the underlying mechanisms remain incompletely understood. Semaglutide, a novel long-acting GLP-1RA, has shown a reduced risk of cardiovascular events. Based on these results, we investigated the therapeutic potential of semaglutide in diabetic cardiomyopathy and sought to elucidate the underlying mechanisms.

Comparative Analysis of Human Brain RNA-seq Reveals the Combined Effects of Ferroptosis and Autophagy on Alzheimer's Disease in Multiple Brain Regions.

Ferroptosis and autophagy are closely associated with Alzheimer's disease (AD). Elevated ferric ion levels can induce oxidative stress and chronic inflammatory responses, resulting in brain tissue damage and further neurological cell damage. Autophagy in Alzheimer's has a dual role.

Overexpression of Heme Oxygenase 1 Enhances the Neuroprotective Effects of Exosomes in Subarachnoid Hemorrhage by Suppressing Oxidative Stress and Endoplasmic Reticulum Stress.

Aims: This study aims to elucidate the therapeutic effects and underlying mechanisms of exosomes derived from Heme oxygenase 1 (HO-1)-overexpressing human umbilical cord mesenchymal stem cells (Exo) in a subarachnoid hemorrhage (SAH) mouse model.

Methods: In this study, exosomes were identified using Western blotting, particle analysis, and transmission electron microscopy. The effect of Exo and Exo on the neurological function of SAH mice was assessed using the Garcia scoring system, Beam balance, Rotarod test, and Morris water maze test.

Dura immunity configures leptomeningeal metastasis immunosuppression for cerebrospinal fluid barrier invasion.

The cerebrospinal fluid (CSF) border accommodates diverse immune cells that permit peripheral cell immunosurveillance. However, the intricate interactions between CSF immune cells and infiltrating cancer cells remain poorly understood. Here we use fate mapping, longitudinal time-lapse imaging and multiomics technologies to investigate the precise origin, cellular crosstalk and molecular landscape of macrophages that contribute to leptomeningeal metastasis (LM) progression.

Promotional effect and mechanism of Ce-modified VO-WO/TiO catalyst in low-temperature NH-SCR.

The enhancement effect of Ce modification on VO-WO/TiO catalysts at low temperatures was investigated for the selective catalytic reduction (SCR) of NO with NH (NH-SCR). By adding 9% CeO to 0.5%VO-3%WO/TiO catalyst, the low-temperature denitrification performance of CeVWTi catalyst after Ce modification was significantly improved, achieving a NO conversion above 90% within a broad temperature range of 200-350℃, with catalytic activity comparable to that of 3% VO-3% WO/TiO.

Metagenomic insights into the resistome, mobilome, and virulome of dogs with diverse lifestyles.

Background: Dogs-whether pets, rural, or stray-exhibit distinct living styles that influence their fecal microbiota and resistomes, yet these dynamics remain underexplored. This study aimed to analyze and compare the fecal microbiota and resistomes of three groups of dogs (37 pets, 20 rural, and 25 stray dogs) in Shanghai, China.

Results: Metagenomic analysis revealed substantial differences in fecal microbial composition and metabolic activities among the dog groups.

Development and validation of a three-dimensional nomogram prediction model for knee osteoarthritis in middle-aged population.

Objectives: This study aims to identify predictors of knee osteoarthritis (KOA) risk in middle-aged population, construct and validate a nomogram for KOA in this demographic.

Methods: From June to December 2020, we conducted a cross-sectional survey on 5,527 middle-aged individuals from Changsha and Zhangjiajie cities in Hunan Province, selected using a stratified multi-stage random sampling method. Data collection involved a structured questionnaire encompassing general demographic, physical condition, and lifestyle behaviors dimensions.

Association analyses of the measurements of the photopic negative response evoked by two ISCEV protocols.

Purpose: To perform association analyses between the measurements of photopic negative response (PhNR) evoked by two ISCEV protocols.

Methods: A total of 172 eyes from 72 post-operative pediatric cataract patients and 24 healthy children were enrolled. The amplitude and peak time of PhNR were analyzed in three eye groups, 1.

Application of indocyanine green-human serum albumin complex in fluorescence image-guided laparoscopic anatomical liver resection: study protocol for a randomized controlled trial.

Background: Indocyanine green (ICG) is a near-infrared fluorescent dye widely used for intraoperative navigation during liver surgeries because of its non-radioactive nature, high safety, and minimal impact on liver function. However, variability in its dosage and concentration and its low imaging success rates have limited its widespread application. To address these issues, we developed a novel ICG-human serum albumin (ICG-HSA) complex to enhance fluorescence visualization during laparoscopic anatomical liver resection.

Clinical and molecular characteristics of 20 Chinese probands with Mucolipidosis type II and III alpha/beta.

Background: Mucolipidosis (ML) II and III alpha/beta are lysosomal disorders caused by mutations in the GNPTAB gene which encodes the alpha and beta subunits of the heterohexameric enzyme, N-acetylglucosamine-1-phosphotransferase.

Method: To explore the clinical and molecular characteristics of the 20 ML II and III alpha/beta patients, clinical data was collected and GNPTAB gene was analyzed by nest PCR and direct Sanger-sequencing. The activity of several lysosomal enzymes was measured in the plasma.

The prognostic impact of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio on patients with small cell lung cancer receiving first-line platinum-based chemotherapy: a systematic review and meta-analysis.

Background: The prognostic significance of Neutrophil-to-Lymphocyte Ratio (NLR) and Platelet-to-Lymphocyte Ratio (PLR) in Small Cell Lung Cancer (SCLC) patients receiving platinum-based chemotherapy is debated.

Methods: This study aims to elucidate their roles in survival outcomes. A systematic search across PubMed, Embase, Web of Science, and Cochrane Library identified relevant studies.

A generalized maximum correntropy based constraint adaptive filtering: Constraint-forcing and performance analyses.

The quadratic cost functions, exemplified by mean-square-error, often exhibit limited robustness and flexibility when confronted with impulsive noise contamination. In contrast, the generalized maximum correntropy (GMC) criterion, serving as a robust nonlinear similarity measure, offers superior performance in such scenarios. In this paper, we develop a recursive constrained adaptive filtering algorithm named recursive generalized maximum correntropy with a forgetting factor (FF-RCGMC).

[Psychosocial and behavioral problems of children and adolescents across five cities in Northern China].

The objective of this research is to study the prevalence and risk factors of psychosocial and behavioral problems in children and adolescents of different ages and genders to provide a scientific foundation for more targeted psychological interventions and social support in the future. From April 21 to May 31, 2023, a cross-sectional survey was conducted using a stratified random sampling method in five cities (Beijing City, Changchun City, Baicheng City, Shenyang City, Hohhot City) across four provinces in Northern China (Beijing, Jilin, Liaoning, Inner Mongolia). The study was conducted using an online questionnaire among children and adolescents aged 6-16 years.

[The correlation between allergic diseases and cardiovascular disease incidence].

Allergic reactions are abnormal responses of the immune system to specific allergens, typically resulting in the release of inflammatory mediators and tissue damage. Cardiovascular diseases are common conditions that contribute significantly to increased mortality rates, with inflammation-induced tissue damage playing a crucial role in their pathogenesis. Allergic reactions are associated with various aspects of cardiovascular diseases, such as hypertension, atherosclerosis, and cardiac remodeling.

[Significance of disorders of brain-gut interaction in the diagnosis and management of refractory constipation].

Chronic constipation is a common digestive disease that affects people's quality of life, with complex causes and difficult treatment. Nearly half of the patients with chronic constipation do not achieve satisfactory treatment results, which is referred to as refractory constipation.Current clinical strategies for addressing refractory constipation have predominantly focused on the mitigation of intestinal symptoms.