Publications by authors named "Zeng-Yan Gao"
Article Synopsis
- * The research found that asthmatic patients have higher ADP levels in their broncho-alveolar lavage fluid (BALF) and that the P2Y1 receptor is highly expressed in their lung tissues.
- * In mouse models, ADP was shown to worsen airway inflammation and attract mast cells, activating the NF-κB signaling pathway and stimulating the secretion of the pro-inflammatory chemokine CXCL10, making ADP a potential target for asthma treatment.
The aim of the present study was to determine the effect of the long non‑coding RNA (lncRNA) bladder cancer‑associated transcript 1 (BLACAT1) in chemoresistance of non‑small cell lung cancer (NSCLC) cells. Expression of lncRNA BLACAT1, microRNA (miR)‑17, autophagy‑related protein 7 (ATG7), multidrug‑resistance protein 1 (MRP1), and the autophagy‑associated proteins light chain 3 (LC3)‑II/LC3‑I and Beclin 1 were detected using the reverse transcription‑quantitative polymerase chain reaction and western blot analysis. Cell viability was determined using an MTT assay.
View Article and Find Full Text PDFMicroRNAs (miRNA) play an important role in tumorigenesis, proliferation, and differentiation. Altered miRNA expression in cancer indicates that miRNAs can function as tumor suppressors or oncogenes. MiR-449c downregulation in non-small cell lung cancer (NSCLC) compared with normal lung tissues was investigated in this study.
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