Publications by authors named "Zeng Q"
Article Synopsis
- Female fertility is essential for family well-being, but factors like chemotherapy and lifestyle changes can negatively affect it, highlighting the need for preservation and restoration efforts.
- Stem cells offer potential solutions through advancements in areas like ovarian tissue freezing, in vitro culture of ovarian tissue, and creating ovarian-like organs.
- The review discusses the importance of stem cell technology in fertility preservation, the need for interdisciplinary collaboration, and personalized treatment strategies for effective fertility solutions.
Article Synopsis
- Bone metastasis from prostate cancer negatively affects patient outcomes, and this study explores the relationship between anoikis (cell death due to lost cell-matrix interactions) and bone metastasis.
- Using various datasets, researchers identified anoikis-related genes (ARGs) and developed a prognostic model based on these genes, revealing significant pathways involved in cancer progression and treatment implications.
- The study concludes that understanding the role of anoikis in prostate cancer can inform therapeutic strategies and highlight patients who may benefit more from chemotherapy rather than immunotherapy.
Article Synopsis
- Accurately classifying primary bone tumors is essential for treatment decisions, yet many medical images are incomplete; this study created a deep learning model using incomplete multimodal images and clinical data.
- The research involved 1305 patients with confirmed bone tumors, employing a new classification model called PBTC-TransNet, which was evaluated based on its accuracy and other performance metrics.
- The model demonstrated strong classification performance with an average AUC of 0.847 for internal tests and shows promise across various imaging modalities, achieving a high accuracy of 84.3% with the best results in X-ray-only cases.
Article Synopsis
- * Researchers performed microarray analysis to identify differentially expressed genes (DEGs) between etoposide-treated and untreated colorectal cancer cells, revealing several key genes that interact with each other.
- * The study found that after etoposide treatment, processes like the cell cycle and metabolism were downregulated, while necroptosis and oncogene pathways were upregulated; two specific genes, LMNB1 and JUN, were identified as potential targets for understanding cancer metastasis.
Flowers serve as hubs for biotic interactions with pollinators and microbes, which can significantly impact plant reproduction and health. Previous studies have shown that the flower microbiota undergoes dynamic assembly processes during anthesis. However, the influence of foraging pollinators on the assembly and dispersal of the flower microbiota and the transmission of plant pathogens remains poorly understood.
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- The study investigates how sodium selenite (SS) can suppress cervical cancer by inhibiting atypical glucose metabolism in cancer cells and identifying the mechanisms behind this effect.
- Experiments showed that SS significantly reduced the growth of cervical cancer cells (HeLa and SiHa) and tumors in mice, without causing harm to the liver or kidneys, and acted through the ROS-mediated AKT/mTOR/HIF-1α pathway.
- The findings suggest that SS's potential as an anti-cervical cancer treatment could lead to new drug development by highlighting its role in inducing oxidative stress and disrupting cancer cell metabolism.
Introduction: The course of maternal antiviral prophylaxis to prevent mother-to-child transmission of hepatitis B virus (HBV-MTCT) varies greatly, and it has not been demonstrated in a randomized controlled study.
Methods: In this multicenter, open-label, randomized controlled trial, eligible pregnant women with HBV DNA of 5.3-9.
Background And Purpose: The triglyceride-glucose (TyG) index, a novel reliable biomarker for IR that incorporates blood glucose and triglyceride, is linked to intracranial atherosclerotic stenosis (ICAS). In this study, we aimed to further investigate the association between the TyG index and the outcomes of ICAS patients following extracranial-to-intracranial (EC-IC) bypass grafting.
Methods: 489 ICAS patients who underwent EC-IC bypass between Jan 2009 and Jan 2022 at our hospital were retrospectively collected.
Article Synopsis
- Hypertension (HT) affects older adults' balance and cerebral cortex function, leading to potential fall risks, with unclear neural mechanisms.
- This study compared balance control and brain activation in 27 older adults with HT and 30 with normal blood pressure across different standing tasks.
- Findings indicated that while center of pressure (COP) movement in HT patients was less dynamic when challenged, their cortical activity was significantly lower, suggesting that brain function may be a better indicator of balance issues in this population than COP alone.
Associations of vaginal microbiota with the onset, severity, and type of symptoms of genitourinary syndrome of menopause in women.
Front Cell Infect Microbiol
October 2024
Article Synopsis
- The study investigates the impact of vaginal microbiota imbalances on the symptoms of genitourinary syndrome of menopause (GSM) in women who are perimenopausal or postmenopausal due to estrogen deficiency.
- A total of 96 women participated, with findings showing that a large percentage experienced GSM symptoms, categorized into genital, urological, and sexual types, and revealing a connection between specific bacteria and the severity of these symptoms.
- Results indicated that Lactobacillus was associated with decreased severity of GSM symptoms, while other bacteria like Escherichia-shigella were linked to increased symptoms, leading to the use of Lactobacillus treatment to potentially alleviate GSM symptoms.
Article Synopsis
- * In a study involving 47,550 cancer patients, researchers found specific protective and hazardous HLA alleles linked to SPC, with certain alleles reducing risk while others increased it, particularly in relation to organ-specific occurrences.
- * The findings indicate that HLA alleles could act as biomarkers for SPC susceptibility, and that diet may influence risk, highlighting the need for personalized dietary recommendations based on HLA status.
Metabolic regulation of the immune system in health and diseases: mechanisms and interventions.
Signal Transduct Target Ther
October 2024
Metabolism, including glycolysis, oxidative phosphorylation, fatty acid oxidation, and other metabolic pathways, impacts the phenotypes and functions of immune cells. The metabolic regulation of the immune system is important in the pathogenesis and progression of numerous diseases, such as cancers, autoimmune diseases and metabolic diseases. The concept of immunometabolism was introduced over a decade ago to elucidate the intricate interplay between metabolism and immunity.
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- Terahertz devices are crucial for terahertz technology but face challenges due to natural materials' poor response in the terahertz band, leading to limited performance.
- A new metamaterial device using vanadium dioxide (VO) has been developed, consisting of an Au layer, SiO layer, and VO layer, showing high reflective and absorptive capabilities at different temperatures.
- The study utilizes models to analyze phase transitions, conductivity, and absorption mechanisms, demonstrating that the device can be used effectively in applications like energy collection and electromagnetic stealth.
Background: Cohort studies have increasingly shown associations between inflammatory markers and myocardial infarction (MI); however, the specific causal relationships between inflammatory markers and the development of MI remain unclear.
Methods And Results: By utilizing publicly accessible genome-wide association studies, we performed a two-sample Mendelian randomization (MR) analysis to explore the causal associations between inflammatory markers and myocardial infarction (MI). A random-effects inverse-variance weighted method was used to calculate effect estimates.
Article Synopsis
- The study looked at how well artificial intelligence (AI) can predict if liver cancer comes back after treatment.
- Researchers checked many AI studies from different databases to gather and analyze data.
- The results showed that AI can accurately predict recurrence for different types of liver cancer treatments, suggesting it could be useful in real-life medical settings.
Metamaterial absorbers show great potential in many scientific and technological applications by virtue of their sub-wavelength and easy-to-adjust structure, with bandwidth as an important standard to measure the performance of the absorbers. In this study, our team designed a new broadband absorber, which consists of an indium arsenide (InAs) disk at the top, a zinc selenide (ZnSe)-chromium (Cr) stacked disk in the middle and a metal film at the bottom. Simulation results show that the absorber has remarkable absorptivity properties in the mid-long infrared band.
View Article and Find Full Text PDFPrimary Aldosteronism Influences Cardiac Structure, Function, and Disease Risk: Evidence From Mendelian Randomization Analysis.
J Clin Hypertens (Greenwich)
November 2024
Although observational studies have linked primary aldosteronism (PA) with cardiovascular diseases (CVDs), the causality remains uncertain. In this study, we aimed to investigate whether PA is causally associated with CVD risk and cardiac magnetic resonance (CMR) parameters using the Mendelian randomization (MR) method. Independent and genome-wide significant single nucleotide polymorphisms for PA were extracted from genome-wide association study (GWAS) summary statistics.
View Article and Find Full Text PDFBackground: Congenital heart disease (CHD), characterized by anatomical and functional abnormalities of the heart, can impair an individual's quality of life and, if not treated with appropriate interventions, it can result in early death. Morbidity and mortality from CHD are greatly reduced by early diagnosis and timely therapy. Therefore, this study aimed to determine the frequency of various forms of CHD among affected children in Eastern Afghanistan considering age, gender, and region of distribution (countryside and city).
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- - The study investigates the genetic differences related to spawning abilities in Pacific white shrimp (Penaeus vannamei) by analyzing structural variations (SVs) in shrimp with high and low fertility.
- - Researchers identified 2,323 SV events in high fertility (HF) shrimp and 1,859 in low fertility (LF) shrimp, linking these variations to specific genes that play a role in reproduction.
- - The findings suggest that certain genes, such as Cttn and Lhcgr, may be key to enhancing fertility in shrimp, providing a foundation for future research and targeted breeding strategies.
Objectives: This quantitative systematic review evaluated whether pulpotomy performed with hydraulic calcium silicate cements may be used as an alternative to root canal treatment (RCT) in mature permanent teeth with carious pulp exposure.
Data Sources: A comprehensive search was conducted in PubMed, Web of Science, Scopus, and the Cochrane Library. No language restrictions were applied.
Article Synopsis
- Primary aldosteronism is marked by high aldosterone and low renin levels, making diagnosis complex when severe hydronephrosis coexists, which can falsely affect test results.
- A 54-year-old man with a history of hypertension and severe hypokalemia faced misdiagnosis of primary aldosteronism due to consistently negative aldosterone-to-renin ratio tests stemming from coinciding severe hydronephrosis.
- After conducting additional tests, including a saline stress test and adrenal vein sampling, the patient underwent successful laparoscopic removal of an adrenal adenoma, leading to initial renal issues but eventual recovery of renal function and potassium levels.
Article Synopsis
- Scientists studied a health problem called MASH, which affects people's livers, and worked on two tests to help doctors tell if someone has it.
- They looked at data from over 3,000 people to make sure their first test, called acMASH, worked well, and then created a new test called acFibroMASH to find more severe cases.
- The new acFibroMASH test was better at predicting who might have future liver problems compared to another test, showing it's a useful tool for doctors to keep patients healthy.
Article Synopsis
- Wetlands are important ecosystems that help store carbon in the soil, but they are being changed into fish and shrimp ponds, which harms them.
- A study in Southeast China found that these aquaculture ponds have less carbon and less diversity in microorganisms compared to natural wetlands.
- Protecting and restoring wetlands could help store more carbon and make soil microbes healthier, which is good for fighting climate change.
Article Synopsis
- Medical texts are difficult to manage and time-consuming to curate manually, prompting the development of NLP algorithms to automate this process for improved efficiency in the biomedical field.
- The study introduces Ascle, a user-friendly tool designed for biomedical researchers that offers generative functions like question-answering and text summarization, along with 12 essential NLP functions and search capabilities.
- After fine-tuning 32 language models and validating through physician assessments, results showed significant improvements in text generation tasks, with notable increases in machine translation and question-answering accuracy.