Isoquinoline alkaloids with bioactive constituents from the roots and rhizomes of .

Isoquinoline alkaloids are important effective chemical components separated from the , which were mostly reported as planar structures. By using chiral HPLC, we have concluded that some natural isoquinoline alkaloids exist as enantiomeric mixtures, providing a novel direction for future research on isoquinoline alkaloids. Finally, three pairs of enantiomeric isoquinoline alkaloids (, including five undescribed compounds-, and ), together with another eight known isoquinoline alkaloids () were isolated from the roots and rhizomes of .

Antitumor effect and mechanism of an ellagic acid derivative on the HepG2 human hepatocellular carcinoma cell line.

In the present study, to identify the effective components of Chinese traditional herbs, Hand.-Mazz. (Euphorbiaceae), a folk herb that has been used among the Qinling mountain area for hundreds of years, was investigated.

New alkaloids from Aconitum taipaicum and their cytotoxic activities.

Three new aconitine-type C19-diterpenoid alkaloids, taipeinines A-C (1-3), were isolated from the roots of Aconitum taipaicum. The chemical structures of these three compounds were established as (1α,6α,8α,14α,16α)-20-ethyl-8,14-dihydroxy-1,6,16-trimethoxy-4-(methoxymethyl)-aconitane (1), (1α,6α,8α,14α,16β)-20-ethyl-8,14-dihydroxy-1,6,16-trimethoxy-4-(methoxymethyl)-aconitane (2) and (1α,6α,8α,14α,16α)-20-ethyl-1,8,14-trihydroxy-6,16-dimethoxy-4-(methoxymethyl)-aconitane (3), respectively, on the basis of spectroscopic analyses, mainly MS, 1D and 2D NMR. The cytotoxic activities of these compounds were also assayed, and the results were quite impressive.

[Analysis of petroleum fraction from flower, stem and leaf of Aconitum taipeicum by GC-MS].

Objective: To analyze the chemical constituents of petroleum fraction of Aconitum taipeicum.

Methods: The methanol extract of Aconitum taipeicum were extracted by petroleum and then analyzed by GC-MS. The compounds were quantitatively determined by normalization method.

Two new amide alkaloids with anti-leukaemia activities from Aconitum taipeicum.

Two new amide alkaloids, named 3-isopropyl-tetrahydropyrrolo [1,2-a] pyrimidine-2,4(1H,3H)-dione (1) and 1-acetyl-2,3,6-triisopropyl-tetrahydropyrimidin-4(1H)-one (2), were isolated from the roots of Aconitum taipeicum. Their chemical structures were characterized on the basis of MS, 1D- and 2D NMR. The anti-leukaemia activities of the compounds were also tested.

[Preliminary study on purification technics of total flavonoids in Rhodiola dumulosa by macroporous resin].

Objective: To choose the best macroporous resin for purifying total flavonoids in Rhodiola dumulosa and study various factors affecting purification of resin in order to optimize the technics.

Methods: Using methods combining static adsorption with desorption and dynamic adsorption with desorption, evaluating the technics by determination of total flavonoids in Rhodiola dumulosa using ultraviolet and visible spectrophotometry.

Results: The best macroporous resin was D101.

[Analysis of petroleum fraction of Aconitum taipeicum by GC-MS].

Objective: To analyze the chemical constituents of petroleum fraction of Aconitum taipeicum.

Methods: The methanol extracts of Aconitum taipeicum were extracted by petroleum and then analyzed by GC-MS. The compounds were quantiatively determined by normalization method.

Pharmacokinetic interaction between tanshinones and polyphenolic extracts of salvia miltinorrhiza BUNGE after intravenous administration in rats.

The objective of this study was to investigate the interaction between tanshinones and polyphenolic extracts of Salvia miltiorrhiza BUNGE in rats. The rats in the medium dose groups were given an intravenous administration of 10 mg/kg tanshinones extract-loaded emulsion (equivalent to 4.0 mg/kg tanshinone IIA (TSIIA)), 100 mg/kg polyphenolic extract solution (equivalent to 61.

[Studies on the methods of extract and determination of total tannins and gallic acids of the root of Euphorbia hylonoma].

Objective: To determine total tannins and gallic acid of the root of Euphorbia hyloomla.

Methods: With the gallic acid as reference, tannins and gallic acid of the root of Euphorbia hylonoma were determined by ultraviolet spectrophtometer and high performance liquid chromatography, respectively.

Results: The content of tannins of the root of Euphorbia hylonoma were determined by different extract methods, including extracted by water, 70% alcohol, acetone on supersound, the determination data were 4.

[Study on chemical constituents of Euphorbia hylonoma hand. -Mazz].

Objective: To study the constituents of the roots of Euphorbia hylonoma Hand. -Mazz.

Methods: The chemical constituents were isolated and purified by solvent extraction together with various chromatographic techniques, the structures were elucidated on the basis of chemical properties and spectral data.