Publications by authors named "Zeng Jiang-Zheng"
Objective: To investigate potential human leucocyte antigen (HLA)-A2-restricted epitope peptides of glypican-3 (GPC3) and determine the cytotoxicity of peptide-specific cytotoxic T lymphocytes (CTLs) against hepatocellular carcinoma (HCC) cells.
Methods: The potential HLA-A*0201-restricted GPC3 peptides were screened using computer algorithms, T2 cell-binding affinity and stability of peptide/HLA-A*0201 complex assay. The peptide-specific CTLs were generated and their cytotoxicity against GPC3 SMMC 7721 and HepG2 cells was detected using IFN-γ based enzyme-linked immunospot and lactate dehydrogenase release assays in vitro.
Article Synopsis
- Anti-angiogenic agents, such as metronomic capecitabine and thalidomide, were tested for their effectiveness in treating advanced hepatocellular carcinoma (HCC) when combined with radiofrequency ablation (RFA).
- In a study with 50 patients, those receiving the combined treatment had a significantly higher tumor response rate (68.2%) at 12 months compared to those who only had RFA (35.7%).
- The treatment also resulted in lower levels of serum circulating endothelial cells (CECs) and vascular endothelial growth factor (VEGF) in patients receiving the combined therapy, suggesting a possible mechanism behind the observed improvement in outcomes.
Aim: To investigate the expression of ornithine decarboxylase (ODC) in precancerous and cancerous gastric lesions.
Methods: We studied the expression of ODC in gastric mucosa from patients with chronic superficial gastritis (CSG, n=32), chronic atrophic gastritis [CAG, n=43; 15 with and 28 without intestinal metaplasia (IM)], gastric dysplasia (DYS, n=11) and gastric cancer (GC, n=48) tissues using immunohistochemical staining. All 134 biopsy specimens of gastric mucosa were collected by gastroscopy.
[Effect of xiaokeling concentration fluid on mRNA expression of insulin-like growth factor-1 in sciatic nerve of Streptozotocin-induced diabetic rats].
Zhong Nan Da Xue Xue Bao Yi Xue Ban
February 2005
Objective: To investigate the effect of xiaokeling concentration fluid on insulin-like growth factor-1 (IGF-1) mRNA expression in sciatic nerve of Streptozotocin-induced diabetic rats.
Methods: Thirty diabetic rats were randomly divided into model group, mecobalamin tablets group, and xiaokeling concentration fluid group. The IGF-1 mRNA level in sciatic nerve of each group was determined after 8 weeks by relative quantity RT-PCR.