Quercetin protected the gut barrier in ulcerative colitis by activating aryl hydrocarbon receptor.

Background: Ulcerative colitis (UC) is characterized by abdominal pain and bloody diarrhoea and restoring the gut barrier is the core goal of UC treatment. Activation of aryl hydrocarbon receptor (Ahr) was reported to effectively alleviate symptoms and repair the gut barrier damage. Neutrophil extracellular traps (NETs) have been recognized as potential targets in the treatment of UC.

Case report: Lobular capillary hemangioma of the right main bronchus: a rare case with calcified and cystic lymph nodes.

Lobular capillary hemangioma (LCH), typically a benign vasoproliferative lesion of the skin or mucosal surfaces, is exceptionally rare in the trachea. Now, we present the second reported case of LCH found in the right intermediate bronchus, characterized by calcification within the lesion and cystic changes. These distinctive features should alert clinicians to consider LCH in the differential diagnosis of other benign vascular tumors and mediastinal lymphadenopathy, particularly when calcified and cystic lesions are observed.

Nonlinear Ultrasonic Characterization of Processing Defects in Wire Arc Additive Manufacturing 316L Stainless Steel.

Wire Arc Additive Manufacturing (WAAM) 316L stainless steel unavoidably introduces defects such as porosity, oxide inclusions, and lack of fusion due to the inherent characteristics of the process. These defects can significantly affect the mechanical properties and service reliability of the material. This study focused on evaluating the defects in WAAM 316L stainless steel by nonlinear ultrasonic testing based on Lamb waves.

Non-nuclear localization signal-guided CRISPR/Cas9 ribonucleoproteins for translocation and gene editing apoferritin delivery vectors.

Direct delivery of the Cas9/sgRNA ribonucleoprotein (RNP) appropriate carriers has been proved to be an important advance for the translocation and gene editing of CRISPR/Cas9. These carriers often require the nuclear localization signal (NLS) to fuse with Cas9 or the NLS-bearing protein to form a complex with Cas9 to enter the nucleus. In this study, we introduced apoferritin nanocages as carriers and DOX as a nuclear trigger for the nuclear transport of the Cas9/sgRNA ribonucleoprotein without the NLS (RNP).

Joint control of multiple food processing contaminants in Maillard reaction: A comprehensive review of health risks and prevention.

There is an urgent need to address food safety concerns associated with multiple Maillard reaction‒derived chemical contaminants, such as acrylamide, heterocyclic aromatic amines, advanced glycation end products, and 5-hydroxymethylfurfural, which are present in processed foods. Current studies have focused on single contaminant generated by the Maillard reaction; however, there is a dearth of information regarding the interactions of multiple contaminants and their joint control methods. This review article comprehensively summarizes the state-of-the-art progress in the simultaneous analysis, coformation, joint hazardous control, and risk assessment of multiple food processing contaminants generated by the Maillard reaction.

Examined lymph node counts affected the staging and survival in cervical cancer: a retrospective study using the SEER and Chinese cohort.

Background: The impact of examined lymph node (LN) count on survival in cervical cancer remains understudied, with no consensus on the optimal number required.

Objectives: We aimed to investigate the role of LN count in postoperative pathological evaluation for cervical cancer patients undergoing surgery.

Methods: Data from the US SEER database and a retrospective Chinese cohort were analyzed.

Cracking the code of acrylamide and Nε-(carboxymethyl)lysine: Fish oil use and predictive strategies in potato chips during thermal processing.

Global high consumption of fried potatoes is driven by appealing taste and edible convenience. However, the occurrence of Maillard reaction hazardous products (MRHPs) and joint control recipes have scarcely been concerned. We aim to reveal and predict how fish oil treatment for potato slices reduces simultaneous formation of typical MRHPs in air-based thermal processed potato chips.

Research Progress in Saltiness Perception and Salty Substitutes.

Salty taste in foods is a key sensory attribute for appetite enhancement, however, consumption of a high salt diet is associated with a high risk of hypertension, stroke, and heart diseases. To address this issue, the World Health Organization (WHO) has recommended reducing the global per capita salt consumption by 30% by 2025, with adults optimally consuming less than 5 g/day of salt. Therefore, the search for new salty substitutes to reduce salt intake in foods has become a research hotspot.

Enhanced piezoelectric photocatalytic activity of MXene/ZnS/FeO via Three-in-One strategy based on dual Schottky heterojunction, interface electric field, and oxygen vacancy for pollutant degradation and removal.

Synergism of piezoelectricity and photocatalysis is an effective approach for pollutant degradation and removal, and has garnered considerable attention. Nonetheless, great challenges still remain in recombination and slow migration rate of charge carriers. For response, a novel Three-in-One strategy based on MXene/ZnS/FeO (MZF) was developed to enhance the piezoelectric photocatalytic activity via achieving a triple effect: Dual Schottky heterojunction, Interface electric field, and Oxygen vacancy.

Role of CALCR expression in liver cancer: Implications for the immunotherapy response.

Liver hepatocellular carcinoma (LIHC) is a prevalent and lethal malignancy with a complex molecular landscape. Fibrosis and ferroptosis are implicated in LIHC progression, yet their roles remain to be elucidated. The present study investigated the expression and prognostic significance of calcitonin receptor (CALCR), a gene that intersects the pathways of fibrosis and ferroptosis, across LIHC and other types of cancer.

PGAM5 promotes RIPK1-PANoptosome activity by phosphorylating and activating RIPK1 to mediate PANoptosis after subarachnoid hemorrhage in rats.

Neuronal death plays a crucial role in early brain injury after subarachnoid hemorrhage (SAH). PANoptosis is a programmed form of cell death regulated by the PANoptosome, which possesses key characteristics of pyroptosis, apoptosis and necroptosis. Phosphoglycerate mutase family member 5 (PGAM5) has specific phosphatase activity that phosphorylates or dephosphorylates serine and threonine residues on bound proteins such as receptor-interacting protein kinase 1 (RIPK1), which are involved in programmed cell death.

A proteogenomic analysis of cervical cancer reveals therapeutic and biological insights.

Although the incidence of cervical cancer (CC) has been reduced in high-income countries due to human papillomavirus (HPV) vaccination and screening strategies, it remains a significant public health issue that poses a threat to women's health in low-income countries. Here, we perform a comprehensive proteogenomic profiling of CC tumors obtained from 139 Chinese women. Integrated proteogenomic analysis links genetic aberrations to downstream pathogenesis-related pathways and reveals the landscape of HPV-associated multi-omic changes.

Differences in the regulation of soil carbon pool quality and stability by leaf-litter and root-litter decomposition.

Litter plays a crucial role in soil ecosystems. However, the differences in decomposition between leaf-litter and root-litter and their relative contributions to soil carbon pools and stability are not yet clear. Therefore, we conducted a 450-day in situ decomposition experiment in a semi-arid grassland to investigate the effects of soil biophysical and chemical properties on litter decomposition and to elucidate the dynamics of soil carbon pools during the decomposition process.

[The Diagnostic Value of Ret-He in Predicting Latent Iron Deficiency in Female Blood Donors].

Objective: To explore the application value of reticulocyte hemoglobin equivalent (Ret-He) for diagnosing latent iron deficiency in female plateletpheresis donors.

Methods: A total of 230 female plateletpheresis donors in Fujian Blood Center from January to February 2022 were selected as the research group and divided into three groups: normal group, iron depletion (ID) group and iron deficient erythropoiesis (IDE) group, according to the severity of iron deficiency. The level of hemoglobin (HGB), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), coefficient of variation of red cell distribution width (RDW-CV) and Ret-He were measured by using the Sysmex XN automated hematology analyzer.

Phase 2 dose-ranging study to evaluate the efficacy and safety of liposomal irinotecan (LY01610) as a second-line treatment for patients with relapsed small cell lung cancer.

Background: This was a multicenter, single-arm dose-ranging phase 2 study aimed to assess the efficacy and safety of LY01610, a liposomal irinotecan, at various doses for patients with relapsed small cell lung cancer (SCLC).

Methods: This study (NCT04381910) enrolled patients with relapsed SCLC at 10 hospitals across China, who have failed with previous platinum-based treatments. LY01610 was administered at doses of 60 mg/m, 80 mg/m, and 100 mg/m.

Clinical efficacy and safety of irreversible electroporation combined with chemotherapy in stage IV pancreatic cancer treatment.

Purpose: This study evaluates the clinical efficacy and safety of irreversible electroporation (IRE) therapy combined with chemotherapy in patients with stage IV pancreatic cancer.

Methods: Between September 2021 and November 2023, we enrolled 38 patients with stage IV pancreatic cancer, with 20 receiving IRE plus chemotherapy and 18 receiving only chemotherapy. We recorded the general information of the patients and regularly followed up postoperative IRE-related adverse reactions.

Hydroxychloroquine loaded hollow apoferritin nanocages for cancer drug repurposing and autophagy inhibition.

Hydroxychloroquine sulfate (HCQ) is currently being repurposed for cancer treatment. The antitumor mechanism of HCQ is inhibition of cellular autophagy, but its therapeutic potential is severely limited by poor solubility, lack of tumor targeting and lower cellular uptake. Therefore, utilization of human H-chain apoferritin (HFn) composed only of heavy subunits is an attractive approach for tumor targeting drug delivery.

Construction of 2D/2D S-scheme BiMoO/Zn-TCPP heterojunction via in-situ self-assembly growth strategy to enhance interface effect for efficient photocatalytic hydrogen production.

Two-dimensional/two-dimensional (2D/2D) heterojunctions are considered to be an effective strategy for forming strong interface effects and facilitating photogenerated carrier separation. However, it is usually limited by the size mismatch of the materials, even at the expense of its redox capability. Herein, 2D/2D S-scheme heterojunction photocatalyst BiMoO/Zn-TCPP (BMO/ZTP) composed of 2D BiMoO and 2D Zn-TCPP (TCPP: tetrakis (4-carboxyphenyl) porphyrin) (MOFs) was constructed by in-situ self-assembly growth strategy.

[Advances in the Application of Nanozymes in Joint Disease Therapy].

Nanozymes are nanoscale materials with enzyme-mimicking catalytic properties. Nanozymes can mimic the mechanism of natural enzyme molecules. By means of advanced chemical synthesis technology, the size, shape, and surface characteristics of nanozymes can be accurately regulated, and their catalytic properties can be customized according to the specific need.