Veno-venous extracorporeal membrane oxygenation as a bridge in central airway obstruction: experience from a high-volume center.

Background: Perioperative airway management and oxygenation maintenance during central airway obstruction (CAO) treatment pose great challenges. While veno-venous extracorporeal membrane oxygenation (V-V ECMO) shows promise as a bridge therapy, optimal implementation and management strategies remain lacking. We present our experience with V-V ECMO in CAO management from a high-volume center.

[Research progress on B vitamins in the treatment of sepsis].

Sepsis is a prevalent form of acute and critical illness encountered in intensive care unit (ICU), characterized by a high mortality and cognitive impairments among survivors. The pathogenesis of sepsis primarily involves immune dysfunction and excessive oxidative stress. Consequently, immune modulation, along with anti-inflammatory and antioxidant strategies, has emerged as a focal point in the treatment of sepsis.

Different fungal signatures in ALD and MAFLD.

Objective: This study investigates the differential impact of fecal fungal microbiota on the pathogenesis of alcohol-associated liver disease (ALD) and metabolic-associated fatty liver disease (MAFLD). We aim to delineate distinct microbial patterns across various stages of each disease.

Methods: We conducted fungal internal transcribed spacer 2 (ITS2) sequencing analysis on fecal samples from 48 ALD patients, 55 MAFLD patients, and 64 healthy controls (HCs).

Discovery and synthesis of novel phenoxyacetate ester Schiff base α-glucosidase inhibitors.

A phenoxyacetate ester Schiff base lead compound 4a (ZINC20073984) was firstly discovered through molecular docking screening and molecular dynamics (MD) simulation, which could be used as an α-glucosidase (PDB: 3A4A) inhibitor. Then a series of α-glucosidase inhibitors 4b-4r with novel structures were designed and synthesized with the lead ZINC20073984 as a template. The results of in vitro α-glucosidase inhibitory activity show that the synthesized phenoxyacetate ester Schiff base compounds 4e, 4o-4r (IC values range from 5.

Long-term health related quality of life in adult extracorporeal membrane oxygenation survivors: a single-centre, cross-sectional study.

Background: This study aimed to evaluate the health-related quality of life of adult survivors of extracorporeal membrane oxygenation and identify the factors influencing their long-term outcomes. The findings are intended to provide a reference for optimizing post-extracorporeal membrane oxygenation care.

Methods: A cross-sectional survey was conducted with 106 adult extracorporeal membrane oxygenation survivors.

Construction of Chiral-Magnetic-Dielectric Trinity Structures with Different Magnetic Systems for Efficient Low-Frequency Microwave Absorption.

The fabrication of carbon nanocoil (CNC)-based chiral-dielectric-magnetic trinity composites holds great significance in low-frequency microwave absorption fields. However, it is not clear that how the different magnetic systems affect the magnetic and frequency responses of the composites. Herein, four types of magnetic metals, FeCo, CoNi, FeNi, and FeCoNi, are selected to be combined with the chiral templates respectively, resulting in four types of chiral-dielectric-magnetic composites with similar morphology.

Self-Assembly Synthesis of Oxygen and Sulfur Co-Doped Porous Graphitic Carbon Nitride Nanosheets for Boosting CO Photoreduction.

Graphitic carbon nitride (CN) has garnered considerable attention in the field of visible-light CO photoreduction, but its efficiency remains limited by the intrinsic π-conjugated skeleton. Here, O and S were co-doped CN (O, S/CN) by a facile "hydrolysis + calcination" approach to modulate the physicochemical and electronic structure. Distinctive from S doped CN (SCN), O, S/CN owned porous layer structure with several nanosheets and less SO groups on the surface.

Dual-functional application of CaTaO:Bi/Eu phosphors in multicolor tunable optical thermometry and WLED.

A series of Bi/Eu co-doped CaTaO (CTO:Bi/Eu) phosphors were prepared by high-temperature solid-state method for dual-emission center optical thermometers and white light-emitting diode (WLED) device. By modulating the doping ratio of Bi/Eu and utilizing the energy transfer from Bi to Eu, the tunable color emission ranging from green to reddish-orange was realized. The designed CTO:0.

Application of fecal immunochemical test in colorectal cancer screening: A community-based, cross-sectional study in average-risk individuals in Hainan.

Background: The incidence of colorectal cancer (CRC) in China is steadily rising, with a high proportion of advanced-stage diagnoses. This highlights the significance of early detection and prevention measures to enhance survival rates. Fecal immunochemical testing (FIT) is a globally recommended CRC screening method; however, limited research has been conducted on its application in Hainan.

Prospective cohort study evaluating efficacy and safety of efgartigimod in Chinese generalized myasthenia gravis patients.

Background: Despite the efficacy of efgartigimod demonstrated in ADAPT phase 3 trial, data specifically derived from Chinese participants are not available. Therefore, we aimed to evaluate the efficacy and safety of efgartigimod in Chinese patients with generalized myasthenia gravis (gMG).

Methods: This is a prospective cohort study conducted in 8 hospitals across China.

Sarcopenia is associated with short- and long-term mortality in patients with acute-on-chronic liver failure.

Background: While sarcopenia is recognized as a predictor of mortality in cirrhosis, its influence on acute-on-chronic liver failure (ACLF) remains uncertain. Despite multiple studies examining the impact of sarcopenia on short-term mortality in patients with ACLF, the sample size of these studies was limited, and their outcomes were inconsistent. Therefore, this study aimed to explore the impact of sarcopenia on both short- and long-term mortality in patients with ACLF.

Construction and validation of a predictive model for the risk of contralateral patent processus vaginalis in children with unilateral inguinal hernia or hydrocele.

To develop a nomogram model for predicting contralateral patent processus vaginalis in children with unilateral inguinal hernia or hydrocele. A retrospective analysis was conducted on 259 children with unilateral inguinal hernia or hydrocele who underwent laparoscopic surgery at the Southern Hospital of Southern Medical University from January 2021 to December 2023. The patients were randomly divided into a training set (n = 207) and a validation set (n = 52) in an 8:2 ratio to analyze the characteristics of CPPV.

Multi-scale microstructural construction in ultralight graphene aerogels enables super elasticity and unprecedented durability for impact protection materials.

Ultralight graphene aerogels have gained extensive recognition in the impact protection field. However, attaining both elasticity and durability at low material density is challenging due to their intrinsic conflicts. Inspired by the mantis ootheca, we present a simultaneous improvement in the elasticity, durability, and density restrictions of ultralight graphene aerogels via constructing a multiscale honeycomb microstructure (MHM) within the graphene skeleton.

Zwitterionic cellulose nanofibers-based hydrogels with high toughness, ionic conductivity, and healable capability in cryogenic environments.

Extreme environmental conditions often lead to irreversible structural failure and functional degradation in hydrogels, limiting their service life and applicability. Achieving high toughness, self-healing, and ionic conductivity in cryogenic environments is vital to broaden their applications. Herein, we present a novel approach to simultaneously enhance the toughness, self-healing, and ionic conductivity of hydrogels, via inducing non-freezable water within the zwitterionic cellulose-based hydrogel skeleton.

Sensors on Internet of Things Systems for the Sustainable Development of Smart Cities: A Systematic Literature Review.

The Internet of Things (IoT) is a critical component of smart cities and a key contributor to the achievement of the United Nations Sustainable Development Goal (UNSDG) 11: Sustainable Cities and Communities. The IoT is an infrastructure that enables devices to communicate with each other over the Internet, providing critical components for smart cities, such as data collection, generation, processing, analysis, and application handling. IoT-based applications can promote sustainable urban development.

Comparison of vonoprazan dual therapy, quadruple therapy and standard quadruple therapy for Helicobacter pylori infection in Hainan: a single-center, open-label, non-inferiority, randomized controlled trial.

Objective: To compare the potential efficacy and safety of dual therapy and quadruple therapy with vonoprazan (VPZ) as well as the standard quadruple therapy of proton pump inhibitor (PPI) for the eradication of Helicobacter pylori (Hp) infection in Hainan province.

Methods: A single-centre, non-blinded, non-inferiority randomized controlled trial was conducted at the outpatient department of gastroenterology at the Second Affiliated Hospital of Hainan Medical University from June 2022 to February 2023. 135 patients aged 18-75 years with Hp infection were enrolled and randomized into three different groups (group V1: VPZ 20 mg twice a day and amoxicillin 1.

Recurrence Rate and Influencing Factors of Helicobacter Pylori Infection After Successful Eradication in Southern Coastal China.

Purpose: Recurrence rate of Helicobacter pylori () infection after successful eradication have gained attention. This study was to assess the recurrence rate of infection after successful eradication in the southern coastal provinces of China and to analyze its factors.

Patients And Methods: 975 patients with upper gastrointestinal symptoms who were diagnosed with using the 13C or 14C-urea breath test (UBT) underwent eradication treatment between August 2021 and December 2022.

Optimizing CRISPR/Cas9 approaches in the polymorphic tunicate Ciona intestinalis.

CRISPR/Cas9 became a powerful tool for genetic engineering and in vivo knockout also in the invertebrate chordate Ciona intestinalis. Ciona (ascidians, tunicates) is an important model organism because it shares developmental features with the vertebrates, considered the sister group of tunicates, and offers outstanding experimental advantages: a compact genome and an invariant developmental cell lineage that, combined with electroporation mediated transgenesis allows for precise and cell type specific targeting in vivo. A high polymorphism and the mosaic expression of electroporated constructs, however, often hamper the efficient CRISPR knockout, and an optimization in Ciona is desirable.

Specification of distinct cell types in a sensory-adhesive organ important for metamorphosis in tunicate larvae.

The papillae of tunicate larvae contribute sensory, adhesive, and metamorphosis-regulating functions that are crucial for the biphasic lifestyle of these marine, non-vertebrate chordates. We have identified additional molecular markers for at least 5 distinct cell types in the papillae of the model tunicate Ciona, allowing us to further study the development of these organs. Using tissue-specific CRISPR/Cas9-mediated mutagenesis and other molecular perturbations, we reveal the roles of key transcription factors and signaling pathways that are important for patterning the papilla territory into a highly organized array of different cell types and shapes.

Prevalence, types, and risk factors of functional gastrointestinal diseases in Hainan Province, China.

To investigate the prevalence, types, and risk factors of functional gastrointestinal diseases (FGIDs) in Hainan Province, China, in order to provide insights for future prevention and treatment strategies. A questionnaire survey was conducted from July 2022 to May 2023, using stratified sampling to sample local residents in five cities (20 townships) in Hainan Province. Out of 2057 local residents surveyed, 659 individuals (32.

Guidelines for Rational Clinical Use of Fentanyl Transdermal Patch.

Pain is one of the most common clinical symptoms of cancer patients, seriously affecting the quality of life of patients and bringing heavy mental and economic burden to families and society. The treatment of cancer pain in China is facing numerous challenges, one of which includes the irrational usage of analgesic drugs in clinical practice. As a strong opioid analgesic, transdermal fentanyl patch has been widely used due to its convenient clinical application and obvious therapeutic effect.

PVT1 promotes proliferation and macrophage immunosuppressive polarization through STAT1 and CX3CL1 regulation in glioblastoma multiforme.

Aims: This study aimed to investigate the role of plasmacytoma variant translocation 1 (PVT1), a long non-coding RNA, in glioblastoma multiforme (GBM) and its impact on the tumor microenvironment (TME).

Methods: We assessed aberrant PVT1 expression in glioma tissues and its impact on GBM cell growth in vitro and in vivo. Additionally, we investigated PVT1's role in influencing glioma-associated macrophages.