Isomer-Effects of Aminophenol Decorated Gold Nanoclusters for HO Photoproduction via Two-Step One-Electron Oxygen Reduction Reaction.

Gold (Au) nanoclustersare promising photocatalysts for biomedicine, sensing, and environmental remediation. However, the short carrier lifetime, inherent instability, and unclear charge transfer mechanism hinder their application. Herein, the Au nanoclusters decorated with three different isomers of o-Aminophenol, m-Aminophenol, and p-Aminophenol are synthesized, namely o-Au, m-Au, and p-Au, which achieve efficient hydrogen peroxide (HO) photoproduction through two-step one-electron oxygen reduction reaction (ORR).

Boosting hydrogen evolution performance of nanofiber membrane-based composite photocatalysts with multifunctional carbon dots.

Recent progress in the co-spinning of nanofibers and semiconductor particles offers a promising strategy for the development of photocatalytic devices, solving aggregation and catalyst recovery challenges. However, composite photocatalysts based on nanofiber membranes often suffer from poor conductivity, low hydrophilicity, and easy recombination of photogenerated electron-hole pairs in the semiconductor components. Here, to tackle the aforementioned issues of ZnInS/polyacrylonitrile (ZIS/PAN) nanofiber-based catalysts, we prepared a composite carbon dots/ZnInS/polyacrylonitrile (CZP) nanofiber membrane by blending carbon dots (CDs) with ZIS/PAN using the electrospinning process.

A Serious Game for Enhancing Rescue Reasoning Skills in Tactical Combat Casualty Care: Development and Deployment Study.

Background: Serious games (SGs) have emerged as engaging and instructional digital simulation tools that are increasingly being used for military medical training. SGs are often compared with traditional media in terms of learning outcomes, but it remains unclear which of the 2 options is more efficient and better accepted in the process of knowledge acquisition.

Objective: This study aimed to create and test a scenario-based system suitable for enhancing rescue reasoning skills in tactical combat casualty care.

Massively parallel CRISPR-assisted homologous recombination enables saturation editing of full-length endogenous genes in yeast.

Performing saturation editing of chromosomal genes will enable the study of genetic variants in situ and facilitate protein and cell engineering. However, current in vivo editing of endogenous genes either lacks flexibility or is limited to discrete codons and short gene fragments, preventing a comprehensive exploration of genotype-phenotype relationships. To enable facile saturation editing of full-length genes, we used a protospacer adjacent motif-relaxed Cas9 variant and homology-directed repair to achieve above 60% user-defined codon replacement efficiencies in genome.

Discovery of β-sitosterol's effects on molecular changes in rat diabetic wounds and its impact on angiogenesis and macrophages.

Diabetes care, particularly for diabetic foot ulcers (DFUs)-related complications, increases treatment costs substantially. Failure to provide timely and appropriate treatment for severe DFUs significantly increases amputation risk. Neovascularization and macrophage polarization play an important role in diabetic wound healing during different stages of the wound repair process.

Polymer-in-Salt Electrolyte from Poly(caprolactone)--polyrotaxane for Ni-Rich Lithium Metal Batteries at Room Temperature.

Solid-state lithium batteries with solid polymer electrolytes have recently attracted extensive attention due to their promising potential in high energy density and safety. However, the principal issues plaguing the solid polymer electrolytes are their restricted ionic conductivities at ambient temperature and the limited tolerance to the widely used high-voltage cathodes (such as LiNiMnCoO, NCM811), thus limiting their practical applications seriously. In this regard, a superior polymer-in-salt solid electrolyte from poly(caprolactone)--polyrotaxane (PGPE) is developed for high-voltage lithium batteries operated at room temperature.

Super-Branched PdCu Alloy for Efficiently Converting Carbon Dioxide to Carbon Monoxide.

The alloying of noble metals with Cu is one of the most effective strategies for improving catalytic performance and reducing cost in electrocatalytic carbon dioxide reduction reactions (CORR). Previous works usually focused on the influence of morphology and composition on the catalytic activity, but lacked the study of the valence state ratio of metals and the electron transfer behavior on alloys. In this work, PdCu-2 alloy (Pd/Cu molar ratio is 1:2) was obtained by a simple one-step solvothermal method, which can effectively convert CO to CO with a maximum Faradaic efficiency (FE) of 85% at -0.

Native and engineered extracellular vesicles for wound healing.

Extracellular vesicles (EVs) that act as messengers mediate communication between parent and recipient cells through their contents, including nucleic acids, proteins, and lipids. These endogenous vesicles have emerged as a novel cell-free strategy for the treatment of diseases. EVs can be released by various types of cells with unique biological properties.

Intra-Articular Biomechanical Changes of the Meniscus and Ligaments During Stance Phase of Gait Circle after Different Anterior Cruciate Ligament Reconstruction Surgical Procedures: A Finite Element Analysis.

Objective: The debate on the superiority of single- or double-bundle for anterior cruciate ligament reconstruction has not ceased. The comparative studies on intra-articular biomechanics after different surgical reconstructions are rare. This study is to evaluate the biomechanical stress distribution intra-knee after single- and double-bundle anterior cruciate ligament reconstruction by three-dimensional finite element analysis, and to observe the change of stress concentration under the condition of vertical gradient loads.

NR2F1-AS1/miR-190a/PHLDB2 Induces the Epithelial-Mesenchymal Transformation Process in Gastric Cancer by Promoting Phosphorylation of AKT3.

The median survival time of patients with advanced gastric cancer (GC) who received radiotherapy and chemotherapy was <1 year. Epithelial-mesenchymal transformation (EMT) gives GC cells the ability to invade, which is an essential biological mechanism in the progression of GC. The long non-coding RNA (lncRNA)-based competitive endogenous RNA (ceRNA) system has been shown to play a key role in the GC-related EMT process.

Differential Expression Profiles and Function Predictions for tRFs & tiRNAs in Skin Injury Induced by Ultraviolet Irradiation.

Ultraviolet (UV) radiation is a major environmental factor contributing skin damage. As UV exposure is inevitable, it is necessary to pay attention to the underlying molecular mechanisms of UV-induced skin damage to develop effective therapies. tRNA-derived stress-induced RNAs (tiRNAs) and tRNA-derived fragments (tRFs) are tRNA-derived small RNAs (tsRNAs) that are a novel class of short, non-coding RNAs.

Anaerobic co-digestion of textile dyeing sludge: Digestion efficiency and heavy metal stability.

Anaerobic co-digestion (AcoD) has become an important mean for the stabilization and recycling of textile dyeing sludge (TDS). Using the soybean okara byproduct (SOB) as a co-digestion substrate, the effects on AcoD performance and heavy metal stability were studied. The results indicated that the optimal mixing ratio was 1:1 (calculated by total sloid).

Recessive/dominant model: Alternative choice in case-control-based genome-wide association studies.

An additive genetic model is usually employed in case-control-based genome-wide association studies. The model usually encodes "AA", "Aa" and "aa" ("a" represents the minor allele) as three different numbers, implying the contribution of genotype "Aa" to the phenotype is different from "AA" and "aa". From the perspective of biological phenomena, the coding is reasonable since the phenotypes of lives are not "black and white".

Development and Validation of a Prognostic Nomogram for Gastric Signet Ring Cell Carcinoma: A Multicenter Population-Based Study.

Background: Gastric signet ring cell carcinoma (GSRCC) is a rare disease associated with poor prognosis. A prognostic nomogram was developed and validated in this study to assess GSRCC patients' overall survival (OS).

Methods: Patients diagnosed with GSRCC from the Surveillance, Epidemiology, and End Results (SEER) database (2004-2016) and the First Hospital of China Medical University (CMU1h) were enrolled in this retrospective cohort study.

Comparison of efficacy between natural orifice specimen extraction without abdominal incision and conventional laparoscopic surgery in the treatment of sigmoid colon cancer and upper rectal cancer.

Purpose: To compare the short-term efficacy between natural orifice specimen extraction (NOSE) without abdominal incision and conventional laparoscopic surgery in the treatment of sigmoid colon cancer and upper rectal cancer.

Methods: A total of 86 patients scheduled to undergo laparoscope-assisted radical surgery of sigmoid cancer or upper rectal cancer from January 2015 to September 2017 (T1-3 stages in preoperative imaging evaluation, no distant metastasis, and body mass index <28 kg/m2) were selected and randomly divided into the NOSE group (no abdominal incision, n=43) and conventional laparoscopy group (LA group, n=43). The operation time, amount of intraoperative bleeding, postoperative exhaust time, postoperative diet time, postoperative hospitalization duration, postoperative pain score and perioperative complications were compared between the two groups.

Effects of degree of carboxymethylation on physicochemical and biological properties of pachyman.

Polysaccharides (pachyman) extracted from Poria cocos sclerotium were chemically modified by carboxymethylation and the effects on the structural and biological properties of the polysaccharides were investigated as a function of the degree of carboxymethylation. The degree of substitution (DS) of five carboxymethylated pachyman, coded as CMP1/CMP2/CMP3/CMP4/CMP5, was determined to be 0.44-0.