Publications by authors named "Zena Del Mundo"
Article Synopsis
- * In addition to its effects on glucose metabolism, insulin affects reproductive health by suppressing the secretion of gonadotropins from the pituitary gland, particularly in states of high insulin levels (hyperinsulinemia).
- * Research using LβT2 gonadotropic cells reveals that insulin stimulation leads to the unexpected movement of GLUT1 transporters to the cell membrane, occurring independently of the typical Akt signaling pathway, suggesting a complex role for insulin in these cells.
Pro-inflammatory macrophage activation is a hallmark example of how mitochondria serve as signaling organelles. Upon classical macrophage activation, oxidative phosphorylation sharply decreases and mitochondria are repurposed to accumulate signals that amplify effector function. However, evidence is conflicting as to whether this collapse in respiration is essential or largely dispensable.
View Article and Find Full Text PDFIntroduction: Female reproductive function depends on a choreographed sequence of hormonal secretion and action, where specific stresses such as inflammation exert profound disruptions. Specifically, acute LPS-induced inflammation inhibits gonadotropin production and secretion from the pituitary, thereby impacting the downstream production of sex hormones. These outcomes have only been observed in acute inflammatory stress and little is known about the mechanisms by which chronic inflammation affects reproduction.
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