[Surgical treatment of malignant neoplasms of the pancreatoduodenal zone].

The experience with surgical treatment of 866 patients with malignant neoplasms of the pancreato-duodenal zone is analyzed. Radical operations were carried out upon 220 (25.4%) patients, palliative ones-upon 459 (52.

[Sodium nucleinate increase of nonspecific macroorganism resistance to conditionally pathogenic and pathogenic microorganisms].

Sodium nucleinate significantly increased the non-specific resistance of mice to E. coli O26, Ps. vulgaris, Ser.

[Aggravation of experimental dysentery in mice and acceleration of the process of multiplication of pathogenic and conditionally pathogenic bacteria under the effect of yeast RNA].

Simultaneous infection of mice with Sh. flexneri subtype 2a, culture, with various doses of RNA sodium salt (NaRNA) or administration of the preparation 3 hours prior to or 6, 12, and 18 hours after the infection was accompanied by aggravation of the experimental infection in mice. This was expressed in a greater number of animals which contracted the disease and died, and in increased blood and peritoneal exudate microbiol density.

[1-time radical operative interventions in malignant ovarian tumors complicated by acute iliofemoral venous thrombosis].

Based on the personal experience with treatment of patients having acute iliofemoral venous thromboses, the authors have elaborated a method of one-moment radical surgical correction in malignant ovarian tumors complicated with acute iliofemoral thrombosis. This technic was successfully performed in the clinic on 3 patients, a good therapeutic effect being gained.

Comparison of interferon-inducing activities and antiviral effects of tobacco mosaic virus, tilorone and sodium nucleinate.

Endogenous interferon was produced in animals in response to the administration of tobacco mosaic virus (TMV), tilorone and sodium nucleinate. The relationship between interferon production and the kind of inducer and the route of its administration was studied. TMV was completely innocuous for Macaca rhesus monkeys and mice and caused no untoward effects in humans upon peroral administration.

[Increasing the non-specific resistance of animals to pathogenic E. coli with preparations of RNA].

Yeast RNA and sodium nucleinate considerably increased the nonsusceptibility of mice to pathogenic escherichia and typhoid salmonellae. Ineffective single nucleonate doses created an intense resistance in repeated use; prolonged application was not accompanied by the appearance of tolerance to the preparation. The principal mechanism of the induced phenomenon consisted in the intensification of the bacterial elimination and the endotoxin detoxification chiefly realized by the activity of the mobile phagocytes.

RNA-induced intensification of antibacterial resistance and aggravation of infection.

The injection of yeast total RNA, transfer RNA or sodium nucleinate into the organism of experimental animals induced the development of non-specific resistance to pathogenic salmonellae, staphylococci and escherichiae 4-6 hours after the administration of the preparations; this resistance persisted during several days. The content of serum lysozyme rose and interferon was induced in the stimulated animals, but the state of resistance was not transferred with serum. It was due to mobile phagocytes the number of which increased considerably and so did their digestive activity.

[Interferonogenic and antiviral activity of the tobacco mosaic virus, tilorone and sodium nucleinate].

Production of endogenic interferon in animals in responce to administration of tobaco mozaic virus, tilorone and sodium nucleinate was shown. Dependence of interferon production on the type of the inductor and the route of its administration was studied. Absolute innocuiuty of the tobaco mozaic virus for monkeys (macaco-resus) and mice, as well as the absence of any side effects in humans treated with it perorally was shown.

[Increasing the non-specific resistance of animals to staphylococcus with official RNA preparations].

A single or double parenteral injection to mice of sodium nucleinate considerably elevated their nonspecific resistance to the virulent staphylococcus as soon as in four hours; the resistance remained marked for four days. Daily prolonged injection of the stimulant also proved to be very effective. In the simulated organism there occurred a significant depression of reproduction of the virulent staphylococci and an increase in the amount of phagocytic cells and their digestive activity.