[Dynamics of free-radical oxidation in suppurative otitis media].

The dynamics of indicators of free-radical oxidation in various purulent-inflammatory diseases of the middle ear in 280 patients was studied. Significant violations of the processes of free radical oxidation in the serum of blood were taken for the patients, the degree of which depends entirely on the severity and nature of the inflammation. A complex treatment with the use of antioxidant therapy in 280 patients was carried out.

Immune Status of Pancreatic Cancer Patients Receiving Cryosurgery.

Cryosurgery used on patients with unresectable pancreatic cancer improved their quality of life, but mainly because of the pain relief. In postoperative patients, multifaceted changes in immunity were found, and the state of the immune system prior to surgery often was a decisive factor to indicate whether further disorders in the postoperative period would develop, or by contrast, it would boost its recovery. Some patients receiving cryosurgery showed immune system imbalance and activation, and of antitumor immunity in particular.

[The features of multiple sclerosis pathological progression verified by the dynamics of biochemical markers of oxidative stress].

Aim: To analyze the features of multiple sclerosis (MS) pathological progression by the parameters of oxidative stress and antioxidant defense system (ADS).

Material And Methods: The study included 220 patients with different clinical forms and phases of MS who were examined and divided into four clinical groups. The intensity of lipid and protein free-radical oxidation (FRO) was evaluated by the level of ketodienes, diene conjugates, malondialdehyde, and Schiff bases.

[Oxidative stress as an indicator of metabolic disorders in the pathogenesis of cerebral stroke].

Aim: To verify the oxidative stress as an indicator of metabolic disorders in the complex pathogenesis of hemorrhagic and ischemic stroke.

Material And Methods: The study included 50 hemorrhagic stroke patients and 50 ischemic stroke patients. A control group consisted of 20 age-matched healthy subjects.

[Biochemical markers of oxidative stress in different forms and phases of multiple sclerosis].

Objective: To verify a role of oxidative stress in the pathogenesis of multiple sclerosis (MS) and to develop oxidative stress prognostic criteria of disease course and treatment recommendations.

Material And Methods: We examined 220 patients with different clinical forms and phases of MS. The lipid and protein free-radical oxidation markers were measured using the following parameters: ketodienes, diene conjugates, malondialdehyde, and Schiff bases.

[Clinical efficacy of immunostimulating drugs in treatment of purulent infections].

81 patients with the acute soft tissue purulent infections were divided in 4 groups and treated with the use of traditional means without immunostimulating drugs; with immunoglobulins; with derinate and combination of both, respectively. The last treatment modality demonstrated maximal clinical efficacy. That is the decrease of the wound contamination period and inflammatory process; acceleration of granulation and epithelization.

[Immune status of patients with exacerbation of chronic suppurative otitis media and its correction].

The authors report results of a clinical and immunological study involving 38 patients with exacerbation of chronic suppurative otitis media. It has demonstrated high immunological and clinical efficiency of combined treatment with derinate (an agent stimulating local immunity) and high molecular-weight polypeptide polyoxidonium. It is concluded that inclusion of these drugs in combined therapy of chronic suppurative otitis media increases its immunological and clinical effectiveness and allows duration of patients' hospitalization to be reduced.

[Prognostic significance of typical immune reactions in myocardial infarction].

Aim: To ascertain the role of typical reactions of the immune system in early prognostication of congestive cardiac failure (CCF) in patients with primary transmural anterior myocardial infarction (MI) in the postinfarction period.

Material And Methods: Typical immune reactions were studied for a year after the disease onset. A total of 228 males aged 40-60 years (mean age 53.

[Immunological disorders and correction of them in surgical patients with atherosclerosis obliterance].

Atherosclerosis obliterance and critical lower limb ischemia lead to immunodeficiency and disbalance of T- and B- components of immune system. Surgical treatment doesn't eliminate but in a number of cases aggravates immune disorders. Immunocorrection stimulates anti-infectious protection.

[Problem of specific and nonspecific factors in the induction and regulation of immunological reactions].

The functional unity of the specific and nonspecific mechanisms of immunological reactions has been shown on the basis of our own investigations and the published data. As revealed in this study, during the formation of immune response smooth transition from the nonspecific level to the specific one occurs. First, the factors of nonspecific protection are switched on, then intermediate reactions develop, further antibodies are synthesized, etc.

[Effect of hyperventilation on the cerebral blood flow and metabolism in patients with craniocerebral trauma].

Cerebral blood flow and metabolism were studied in 44 patients with acute severe craniocerebral injuries (contusions of the brain and removal of intracranial hematomas) with consciousness depression (moderate coma), hospitalized in intensive neurological care wards. Oxygen supply to the brain was repeatedly evaluated (acid-base status of the jugular vein blood, oxygen arterio-venous difference, oxygen extraction coefficient), oxymetry of the brain was repeatedly carried out, and vital functions were monitored over the entire period of disease. Cerebral blood flow was monitored by rheoencephalography, which helped timely detect the changes in cerebral blood flow in patients with craniocerebral injuries during different ventilation protocols used in intensive care.

[Efficiency of immune correction in patients with chronic traumatic mandibular osteomyelitis].

The effect of a new immunomodulator neovir was studied in 35 patients with chronic traumatic mandibular osteomyelitis. The immune status and clinical parameters notably improved.

[Correction of immunologic reactivity depending on ABO system antigens in patients with purulent infections of soft tissue and shigellosis].

The immunological study of more than 300 patients with purulent infection of soft tissues and shigellosis was carried out. The character and manifestation of the immunocorrecting action of sodium nucleinate were found to depend on the antigens of the AB0 system, which proved to be different in various type of pathology.

[Impaired immune response associated with ABO antigen system in patients with purulent abscesses and dysentery].

On the basis of a considerable number of facts--the results of the immunological survey of 197 patients with purulent infections of soft tissues and 103 shigellosis patients--the character and manifestation of immunological disturbances were found to depend on the genetic markers of blood (antigens of the AB0 system) which proved to differ in different type of pathology in patients.

[Blood group-dependent efficiency of immunological correction in patients with chronic purulent otitis media].

Clinical and immunological investigations were performed in 300 patients with otitis media chronica purulenta. The patients, aged 16-65 years, received immunocorrectors in addition to basic postoperative therapy consisting of antibiotics and antihistamine drugs. The highest immunocorrective effect was registered in patients with blood group AI, the weakest in those with blood group AB(IV).

[The characteristics of the clinical manifestations and treatment of chronic obstructive bronchitis in patients with hepatobiliary system diseases and pseudoallergy].

Routine clinical, laboratory, instrumental and immunological examinations in 105 patients have established that hepatobiliary disorders occur 2.2 times more frequently in patients with chronic obstructive bronchitis (COB) and pseudoallergy than in those without pseudoallergy. To correct negative effects of pseudoallergy, conventional therapy was combined with enterosorbent polyphepan, spasmolytic nospa and cholagogic allochol used alone or in different combinations.

[Available methods of evaluation and correction of immune disorders in patients].

A three-stage scheme for detecting and correcting immunodeficiency is proposed. The first stage is the interview from which the physician may suspect secondary immunodeficiency, the second is assessment of changes in the leukogram, and the third stage is correction of immune disorders with consideration for the immunodeficiency syndrome(s) detected.

[Methods for assessing the efficacy of immunocorrection].

The use immunocorrective remedies has become a topical problem due to the insufficient effectiveness of the treatment of many chronic diseases (including chronic purulent otitis), manifested by the suppression of initial immunological disturbances. Still the principles of the prescription of the above-mentioned remedies have not yet been sufficiently worked out. The present work deals with the use and approval of the methods for the evaluation of the effectiveness of immunocorrective therapy, the determination of the targets of action, the proper effect of modulation, changes in the degree of its manifestation.

[Dependence of immunological reactivity on blood groups and microflora in patients with chronic purulent otitis media].

Immunological investigation (1-2 level tests with monoclonal antibodies) of 246 OMPC patients has discovered a relationship between the degree of immunological disorder, blood group and microflora. Patients carrying AII and ABIV, Pseudomonas aeruginosa, Staphylococcus aureus, Proteus were more immunologically compromised. These findings may help in the choice of profile immunocorrector.

[A deficient T-cell count and its elimination during the treatment and prevention of infections].

The results of the study of the parameters of the immune system in persons suffering from frequent infections, bacteriocarriers and persons with nonspecific infections are presented. The study revealed that T-cell deficiency of the 2nd and 3rd degrees could be regarded as the universal marker of decreased immune reactiveness. Sodium nucleinate was found to be capable of stimulating the T-cell element of immunity and antibody formation, which made it possible to achieve a considerable decrease in morbidity rate.