[The follow-up results of patients with necrotic suppurative forms of diabetic foot syndrome].

Follow-up results of 162 patients with necrotic suppurative forms of the diabetic foot syndrome (DFS) are studied in a period of 6 months to 7 years. 51.35% of patients with neuropathic form of DFS (NPDFS) relapsed, whereas among patients with neuroischemic form (NIDFS) relapse was reported in 61.

[Differential diagnostics of acute inflammatory diseases and tumors of the neck].

The purpose of the investigation was to assess the clinical significance of ultrasonography for differential diagnostics between acute inflammatory and tumorous lesions of the neck. One hundred and eighty-six patients with soft-tissue lesions of the neck aged 18 to 74 (mean age 31.45 +/- 8.

[Antiedematous effect of diphenyliodinium salts on experimental toxic lung edema].

A series of diphenyliodinium (DPI) salts (chloride, sulfate, acetate and iodide) were synthesized and studied as preventive and therapeutic agents in the model toxic lung edema induced by thiourea and phosgene in rats. All DPI salts exhibited high antiedematous activity. The preventive action of drugs was more effective than their curative effect.

[Hemostasis system disturbances and their correction in patients with pyonecrotic forms of diabetic foot].

Severe hypercoagulation syndrome was diagnosed in patients with various forms of diabetic foot. Pathology at coagulogram parameters reflects systemic metabolic and inflammatory disturbances. Anticoagulant therapy should be combined with correction of glycemia, treatment of infection and critical ischemia.

[Clinical importance of early diagnosis of anaerobic non-clostridial infection].

Anaerobic infection is one of the most complicated problems of pyosurgery. The algorithm of examination of patients with anaerobic infection including intraoperative diagnosis is proposed. Surgical treatment playing also diagnostic role is the basis of combined treatment of soft tissues anaerobic infection.

[Antioxidant system of the rat brain in toxic lung edema].

The state of enzymatic and nonenzymatic components of antioxidant system and also lipid peroxidation processes were studied in brain of rats with toxic pulmonary edema induced by inhalation of nitric oxides. The changes in the state of antioxidant system components in brain accompanied the development of toxic pulmonary edema. The main changes were found in nonenzymatic components of the antioxidant system, particularly in thiol and disulfide groups.

[Pathogenesis and combined surgical treatment of the pyonecrotic diabetic foot].

Three hundred and fifteen patients with necrotic forms of diabetic foot were examined and treated. Neuropathic infected form of diabetic foot was diagnosed in 45.7% patients, neuro-ischemic form--in 54.

[Disorders of protein C anticoagulant system in various clinical conditions].

A study was carried out on activity of protein C4 in 73 surgical patients (coagulation test, reagents of company PEHAM). The reduction in activity of protein C was observed in patients with focal liver lesion related to disturbance of protein formation function. This percent of disturbances in protein C system is more often found in patients with vascular pathology.

[Antihypoxic and antiedemic activity of new condensed indole derivatives].

The antihypoxic and antiedemic activity of a series of new indole derivatives and condensed systems, including pyrimido-, thiazolo-, and triazinoindoles, was studied on the hypobaric hypoxic hypoxia ad toxic lung edema models. Several thiazoloindole and formylindole derivatives prevented the loss of experimental animals under hypoxia conditions and significantly reduced the toxic lung edema development. The pharmacological activity of these compounds was comparable with or exceeded that of the standard antihypoxic and antiedemic drugs.

[Neutrophilic respiratory response in surgical infection and an association with plasma membranous synthesis of ATP].

Early studies have demonstrated that the unique phenomenon ATP aerobic synthesis on neutrophilic plasma membranes is observed when neutrophils are activated with the chemoattractive peptide FMLP. This paper presents the results of the study of a possible association of ATP plasma membranous synthesis with priming, with the occurrence of respiratory explosion and apoptosis of the neutrophils isolated from the blood of donors and patients with surgical infection of different severity. The interaction of neutrophilic plasma membranes with FMLP and with hTNF (was attended by ATP synthesis.

[Immune status in diabetic patients with pyo-necrotic lesions of lower extremities].

Long-term and severe pyonecrotic processes in diabetic patients testify to severe disorders of immune system in this disease. High titer of antibodies to tested autostrain demonstrated its etiologic role in infectious process. The study group consisted of 29 patients (with diabetic pyonecrotic foot lesions), control group--17 patients with burns of III a, b--IV stage affecting from 20 to 60% of body surface.

[Experience in the use of vessel due F (sulodexide) in patients with suppurative-necrotic forms of diabetic foot without critical ischemia].

Aim: To evaluate effectiveness of sulodexide in patients with pyonecrotic complications of diabetic foot.

Material And Method: Sulodexide was given to 15 patients which were examined for blood fibrinogen, foot tissues saturation with oxygen, microbic contamination of the wound tissue. In addition, ultrasound dopplerography of foot arteries, laser doppler flowmetry were performed.

[Development of preventive and emergency therapy means for poisonous and highly toxic substances].

Threat of accident development at the chemical industry objects, as well as tasks of medical support in chemical weapon destruction necessitate improvement of the toxicant biological indication methods, creation of protective-decontaminating prescriptions to protect open areas of skin, and also development of etiotropic and pathogenetic therapy agents for poisonings The Scientific-Research-Test Center (Medicobiologic Protection) studies of every of the above trends have allowed to create and introduce into table medical support of the RF Armed Forces some new indication-means samples, antichemical packets, antidotes and means of pathogenetic therapy for convulsive and bronchospastic syndromes, to motivate use of pharmacological agents to stop toxic pulmonary edema and cardio-vascular failure.

[Status of the blood and lung antioxidant system of the rat in toxic pulmonary edema].

The state of enzymatic and non-enzymatic components of antioxidant system and also lipid peroxidation processes in blood and lungs of rats with toxic pulmonary edema induced by inhalation of nitric oxides were investigated. The changes in the state of blood and lung antioxidant system components accompany the development of toxic pulmonary edema and coincide in time-course of edema manifestation. The determined changes were more pronounced in blood than in lungs.

[Substantiation and varieties of complex surgical treatment tactics for pyo-necrotic forms of diabetic foot].

For the period from 1996 to 1998 in the Division of wounds and wound infection of A.V. Vishnevsky Institute of Surgery 92 patients with pyonecrotic forms of "diabetic foot" underwent thorough examination and treatment.

[A morphological and electron radioautographic study of the wound in the diabetic foot syndrome].

Two groups of patients with a grave form of diabetes mellitus type I and II with diabetic foot syndrome have been examined. Group 1 (21 cases) consisted of patients whose foot was amputated. The cause of the necrotic process was ischemia produced by alteration of the arterial vessels aggravated by infection.

[The surgical procedure in sigmoid obstruction].

The authors report on operations on 280 patients for diseases of the sigmoid colon (106 patients with acute ileus included). Results of different operations and the technique of the exclusion of the dolichosigmoid are described.

[A morphological evaluation of single-row and double-row sutures on the colon].

Morphological investigations in experiment have shown that healing of anastomoses on the colon made with a two-row suture is more favorable than when a one-row suture is used. So, the two-row suture is recommended for wide clinical use as more expedient for anastomoses on the colon.

[The immediate and late results of Billroth-I gastric resection with the application of the single-row suture].

An experience with gastric resections in 942 patients with ulcer disease of the duodenum is presented. Billroth-I resection was used in 760 patients (81%). The posterior wall of the gastroduodenal anastomosis was formed with the help of a one-row blanket catgut suture in 118 of these patients.