Publications by authors named "Zemin Chen"

As a gatekeeper of the airway epithelial cells, E-cadherin is not only a critical component for the maintenance of epithelial integrity, but also engaged in pathological processes through the release of a soluble form (sE-cadherin). This study was aimed to investigate the role of sE-cadherin in ALI/ARDS. Serum samples from patients with ARDS and healthy volunteers were collected for the detection of sE-cadherin.

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Background: Mixed granulocytic asthma (MGA) is usually associated with poor response to corticosteroid therapy and a high risk of severe asthma. Cathepsin S (CTSS) has been found to play an important role in various inflammatory diseases. This study was aimed to investigate the role of CTSS in MGA.

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Article Synopsis
  • - Strong metal-support interactions (SMSI) help stabilize very small metal sites (sub-2 nm) like single atoms or clusters, but optimizing these sites to improve both activity and stability is challenging.
  • - The study introduces a new approach combining SMSI with reactive metal-support interactions (RMSI) to optimize the performance of nickel (Ni) clusters, resulting in the formation of a specific metal phosphide cluster (Ni2Pn).
  • - This synergistic approach enhances the catalytic activity of Ni2Pn for selective hydrogenations, achieving product formation rates that are significantly higher than those for the other nickel sites tested.
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Article Synopsis
  • Severe asthma has problems with its airway barrier, and a key protein called E-cadherin can be turned into a different form that might cause issues.
  • Researchers studied how this new form, called sE-cadherin, affects asthma by using samples from healthy people and asthma patients, and testing in mice.
  • They found that high levels of sE-cadherin in asthma patients are linked to worse symptoms, and blocking it in mice helped reduce inflammation and problems in their airways.
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Precise control over the size, species, and breakthrough of the activity-selectivity trade-off are great challenges for sub-nano non-noble metal catalysts. Here, for the first time, a "multiheteroatom induced SMSI + in situ P activation" strategy that enables high stability and effective construction of sub-2 nm metal sites for optimizing selective hydrogenation performance is developed. It is synthesized the smallest metal phosphide clusters (<2 nm) including from unary to ternary non-noble metal systems, accompanied by unprecedented thermal stability.

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Objective: Down-regulation of bronchial epithelial E-cadherin is an important of feature of severe asthma, including steroid-insensitive asthma. Yet, the mechanisms involved in E-cadherin disruption are not fully understood. This study was aimed to investigate the role of glucose transporter 1 (GLUT1) in dysregulation of E-cadherin in toluene diisocyanate (TDI)-induced steroid-insensitive asthma.

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Article Synopsis
  • The study explores the role of ferroptosis, a regulated cell death process, in disrupting E-cadherin expression in asthma, particularly in mixed granulocyte asthma (MGA).
  • Using murine models induced by toluene diisocyanate and ovalbumin, researchers found that allergen exposure led to mitochondrial shrinkage, ferroptosis markers changes, and a significant reduction in E-cadherin levels in airway epithelia.
  • Treatment with ferroptosis antagonists improved lung function, reduced inflammation, and restored E-cadherin expression, suggesting that ferroptosis plays a crucial role in the cellular dysfunction associated with asthma.
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Liquid-based interface behaviors at micro/nano or even smaller scales induced by biomolecules take us into a fascinating realm, fostering a deeper understanding and innovation in visual biosensing. This biosensing technology, grounded in specific liquid-based interface behaviors, redefines how diseases can be detected, monitored, and diagnosed in resource-limited settings, providing rapid, cost-effective, and self-testing solutions to the current healthcare landscape. To date, the technology has witnessed significant advancements in visual sensing, driven by diverse liquid-based materials, advanced nanomanufacturing techniques, and a profound understanding of interface-material interactions.

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Asthma is quite heterogenous and can be categorized as eosinophilic, mixed granulocytic (presence of both eosinophils and neutrophils in the airways) and neutrophilic. Clinically, mixed granulocytic asthma (MGA) often tends to be severe and requires large doses of corticosteroids. High mobility group box 1 (HMGB1) is one of the epithelium-derived alarmins that contributes to type 2 inflammation and asthma.

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Article Synopsis
  • Gastric adenocarcinoma of the fundic gland type (GA-FG) is a rare type of tumor that has not yet reached a consensus on classification and characteristics.* -
  • Based on studies from 2007 to 2021, 327 cases of GA-FG have been documented, showing specific features during endoscopic examinations, mainly presenting as small, solitary lesions in the upper stomach with certain patterns.* -
  • Although generally benign, GA-FG can invade submucosal layers and is typically treated effectively with endoscopic techniques like endoscopic submucosal dissection (ESD) and endoscopic mucosal resection (EMR).*
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Background: Loss of E-cadherin in the airway epithelial cells is a critical contributor to the development of ALI/ARDS. Yet the underlying mechanisms are largely unknown. Increasing evidences have revealed the significance of ferroptosis in the pathophysiological process of ALI/ARDS.

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Dysfunction of epithelial barrier is crucial for the development of acute lung injury (ALI). This study was aimed to evaluate the role of glucose transporter 1 (GLUT1) in dysregulation of epithelial tight junction in ALI. GLUT1 was inhibited with specific antagonists WZB117 or BAY876 to see the effects on epithelial tight junction in a well-established LPS-induced mouse ALI model as well as in vitro cultured epithelial cells.

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Background: USPs are a family of enzymes that regulate protein degradation, and their dysregulation has been implicated in the development and progression of cancer.

Aims: This study aimed to determine whether ubiquitin-specific proteases 3 (USP3) could be a potential target for therapy in hepatocellular carcinoma (HCC), particularly in resistant HCC. This study systematically investigated the role of USP3 in HCC, with a focus on chemo-resistant HCC cells.

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Peptidoglycan recognition proteins (PGRPs) are one of the receptors in insects' immune pathways, essential for insects to recognize the exogenous pathogens in order to activate the Toll and immune deficiency (IMD) pathway. In the silkworm Bombyx mori, previous studies focused on the short PGRPs and less is known about the long PGRPs. In this study, a long PGRP in silkworm BmPGRP-L4 was cloned and its expression and function were analysed.

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The transformation of renewable platform molecules to produce value-added fuels and fine-chemicals is a promising strategy to sustainably meet future demands. Owing to their finely modified electronic and geometric properties, carbon-based nanocatalysts have shown great capability to regulate their catalytic activity and stability. Their well-defined and uniform structures also provide both the opportunity to explore intrinsic reaction mechanisms and the site-requirement for valorization of renewable platform molecules to advanced fuels and chemicals.

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An 8-week feeding trial was performed to evaluate the effects of dietary leucine (Leu) and valine (Val) levels on growth performance, glycolipid metabolism and immune response in Oreochromis niloticus. Fish (15.23 ± 0.

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Strong metal-support interaction (SMSI) is crucial for supported catalysts in heterogeneous catalysis. Here is the first report on strong metal phosphide-phosphate support interaction (SMPSI). The key to SMPSI is the activation of P species on the support, which leads to simultaneous generation of metal phosphide nanoparticles (NPs) and core-shell nanostructures formed by support migration onto the NPs.

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Colorectal cancer (CRC) is the third-most common cancer around the world, accounting for approximately 10% of cancer-related mortality. Deeper molecular understanding of colorectal carcinogenesis will provide evidences for identification of early diagnostic indicators and novel therapeutic strategies for CRC treatment. The p21 -activated kinase 5 (PAK5) has been reported to be involved in a variety of tumor-promoting behaviors, whereas the underlying mechanisms of PAK5 in CRC progression are still obscure.

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Objective: To determine whether the effectiveness of core stability exercises correlates with the severity of spinal stenosis in patients with degenerative lumbar spinal stenosis.

Methods: Forty-two patients with degenerative lumbar spinal stenosis treated in the department of orthopedics of our hospital between May 2013 and January 2016 were included in the study. All the patients performed core stability exercises once daily for six weeks, and the clinical outcomes were evaluated using Japanese Orthopaedic Association (JOA) score and self-reported walking capacity.

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