Infrequent alteration of the DPC4 tumor suppressor gene in renal cell carcinoma.

The aim of this study was to investigate the alterations in the DPC4 tumor suppressor gene in renal cell carcinoma (RCC). The study included 32 tumor specimens from Croatian patients with a diagnosis of RCC. Loss of heterozygosity (LOH) was investigated using three specific oligonucleotide primers for the three DPC4 polymorphic markers.

Comparative analysis of azithromycin and clarithromycin efficacy and tolerability in the treatment of chronic prostatitis caused by Chlamydia trachomatis.

A total of 123 patients, older than 18 years of age, with symptoms of chronic prostatitis and inflammatory findings as well as the presence of Chlamydia trachomatis confirmed by DNA/RNA DIGENE hybridization method in expressed prostatic secretion or in voided bladder urine collected immediately after prostatic massage, were examined. The patients were randomized to receive a total of 4.5 g of azithromycin for 3 weeks, given as a 3-day therapy of 1 x 500 mg weekly or clarithromycin 500 mg b.

[Prostate gland-transition zone lesions. Etiology, growth regulation, growth factors, genetic changes].

Human prostate gland is a composite organ made up of several glandular and nonglandular components. There are three distinct glandular regions. These are the peripheral, the central, and the transition zone.

Human papillomaviruses are not associated with renal carcinoma.

In an attempt to better understand the troubling issue of renal human papillomavirus (HPV) infection, fresh tumour specimens obtained by surgical extirpation from tumours were compared for the presence of HPV. All of the renal carcinoma samples were examined by PCR using two sets of consensus primers and the specific primer pairs for HPV 16, 18, and 33. None of the 28 carcinomas and 17 corresponding normal tissues were found positive for HPV DNA in any of the applied analyses.

Loss of heterozygosity of the nm23-H1 gene in human renal cell carcinomas.

This study evaluates the potential contribution of the nm23-H1 gene to malignant transformation in patients with renal cell carcinoma. Using specific oligonucleotide primers for the nm23-H1 microsatellite repetitive sequence, gene instability was followed by polymerase chain reaction/loss of heterozygosity assay on 54 tumor specimens and the corresponding normal tissue samples. We also determined, immunohistochemically, the relative concentration and localization of the nm23-H1 protein product.

[Results in the reconstruction of the pyeloureteral segment using the Anderson-Hynes method].

In an introduction the authors take into consideration the term Hydronephrosis and then they reviewed indications for a correction-repair of a pyelo-ureteral segment. There is shortly presented what is to be expected from an "ideal" procedure for a such reconstruction and then the operative technique of Anderson-Hynes method is described. They have operated on 37 patients using this procedure and according to X-ray finding (Degree of dilatation of calices and pyelon) patients were divided into four groups.