High micronucleus frequency in peripheral blood lymphocytes of untreated cancer patients irrespective of gender, smoking and cancer sites.

Chromosomal instability could be one of primary causes for malignant cell transformation. The objective of the present study was to evaluate the spontaneous genetic damages in circulated lymphocytes of newly diagnosed cancer patients by using cytokinesis-block micronucleus (CBMN) assay, with respect to the factors that might affect micronucleus frequency (i.e.

Radiation therapy with or without concurrent low-dose daily chemotherapy in locally advanced, nonmetastatic squamous cell carcinoma of the head and neck.

Purpose: To retrospectively investigate the difference between conventionally fractionated (CF) and hyperfractionated (Hfx) radiation therapy (RT), with and without either daily cisplatin (CDDP) or carboplatin (CBDCA), in patients with locally advanced squamous cell carcinoma of the head and neck (SCCHN) enrolled onto two consecutive prospective randomized studies.

Patients And Methods: Treatment consisted of CF RT (70 Gy, group 1), CF RT and either daily CDDP (6 mg/m2) or daily CBDCA (25 mg/m2; group 2), Hfx RT (77 Gy, 1.1 Gy bid; group 3), or Hfx RT and daily CDDP (group 4).

[Cytology in the diagnosis of diseases of the nose and maxilary sinuses].

The aim of this work is to evaluate cytologic examination of secretions of nose and maxillary sinuses in patients with naso-sinusal disorders. The material for cytologic examination is taken from 128 nasal cavities of 101 patients with inflammation or tumour diseases of nose and maxillary sinuses, and from 114 maxillary sinuses, intraoperatively, of 89 patients. The results of cytological examinations were classified in five groups: acute bacterial inflammations, chronic bacterial inflammations, allergic processes, viral infections and positive findings for malignancy.

[Relation between size of the nasopharynx and occurrence of chronic otitis media].

Aetiopathogenesis of chronic middle ear inflammation has not yet been sufficiently elucidated. Eustachian tube infection, causative organism virulence, immune status and biologically predisposed middle ear mucosa play the major role. The study was aimed at evaluation of the correlation between nasopharyngeal size and development of chronic middle ear inflammations.