Microwave-assisted reductive homocoupling of aromatic nitro monomers: synthesis of azo-linked porous organic polymers for CO capture.

An optimized protocol for the rapid synthesis of azo-linked porous organic polymers (POPs) containing trigonal triphenylpyridine (AZO-P-M), triphenyltriazine (AZO-T-M), and tetragonal tetraphenylethylene (AZO-E-M) central units by microwave-assisted NaBH-mediated reductive homocoupling of the corresponding aromatic nitro monomers is presented. The structural and functional features of the azo-linked polymers prepared under microwave heating were directly compared to their counterparts obtained by conventional synthesis. Similar to azo-linked polymers synthesized by conventional reductive homocoupling of nitro monomers with NaBH, the polymers prepared under microwave irradiation are amorphous solids of good thermal stability showing moderate (, AZO-E-M with BET surface area of 302.

Disulfide-Containing Nitrosoarenes: Synthesis and Insights into Their Self-Polymerization on a Gold Surface.

Disulfide-containing nitrosoarenes with [bis(4-nitrosobenzyl) disulfide, ()] or without [4-nitrosophenyl disulfide, (), and 1,2-bis(4'-nitroso-[1,1'-biphenyl]-4-yl)disulfane, ()] an alkyl spacer between the sulfur headgroup and the aromatic moiety (phenyl in () or biphenyl in ()) were synthesized and used as precursors to form azodioxy thiolate films on Au(111) substrates. Due to the incorporated disulfide functionalities, these specifically designed nitrosoarenes are enabled to self-polymerize through azodioxy bonds on a gold surface. Thin films of (), (), and () were prepared at different adsorption times via the solution-phase self-assembly of molecules onto the Au(111) surface and characterized by Raman spectroscopy, ellipsometry, water contact angle measurements, atomic force microscopy (AFM), and scanning tunneling microscopy (STM).

Synthesis of aromatic polynitroso compounds: Towards functional azodioxy-linked porous polymers.

The polymerization property of aromatic polynitroso compounds could be used to create azodioxy porous networks with possible application for the adsorption of CO, the main greenhouse gas. Herein, we report the synthesis and characterization of new aromatic polynitroso compounds, with -nitroso groups attached to the triphenylbenzene, triphenylpyridine, triphenyltriazine and triphenylamine moiety. The synthesis of the pyridine-based trinitroso compound was performed by reduction of the corresponding trinitro derivative to -arylhydroxylamine followed by oxidation to the trinitroso product.

The Application of Deep Learning for the Evaluation of User Interfaces.

In this study, we tested the ability of a machine-learning model (ML) to evaluate different user interface designs within the defined boundaries of some given software. Our approach used ML to automatically evaluate existing and new web application designs and provide developers and designers with a benchmark for choosing the most user-friendly and effective design. The model is also useful for any other software in which the user has different options to choose from or where choice depends on user knowledge, such as quizzes in e-learning.

A Systematic Literature Review of Handheld Augmented Reality Solutions for People with Disabilities.

Mobile applications on smartphones and tablets have become part of our everyday lives. The number of augmented reality (AR) technology applications is also increasing. Augmented reality has proven to be effective in various areas of human life, from education, marketing, and training to navigation.

Synthesis and Immunological Evaluation of Mannosylated Desmuramyl Dipeptides Modified by Lipophilic Triazole Substituents.

Muramyl dipeptide (-acetylmuramyl-L-alanyl-D-isoglutamine, MDP) is the smallest peptidoglycan fragment able to trigger an immune response by activating the NOD2 receptor. Structural modification of MDP can lead to analogues with improved immunostimulating properties. The aim of this work was to prepare mannosylated desmuramyl peptides (ManDMP) containing lipophilic triazole substituents to study their immunomodulating activities in vivo.

Design, Synthesis, and Biological Evaluation of Desmuramyl Dipeptides Modified by Adamantyl-1,2,3-triazole.

Muramyl dipeptide (MDP) is the smallest peptidoglycan fragment able to trigger the immune response. Structural modification of MDP can lead to the preparation of analogs with improved immunostimulant properties, including desmuramyl peptides (DMPs). The aim of this work was to prepare the desmuramyl peptide (L-Ala-D-Glu)-containing adamantyl-triazole moiety and its mannosylated derivative in order to study their immunomodulatory activities in vivo.

Adamantyl pyran-4-one derivatives and their in vitro antiproliferative activity.

Pyran-4-one (maltol, kojic acid and chlorokojic acid 1) esters of adamantan-1-ylacetic acid were prepared through efficient synthetic routes in good yields and evaluated for their in vitro antiproliferative activity on four cancer cell lines: K562 (chronic myelogenous leukemia), HeLa (cervical cancer), Caco-2 (colorectal adenocarcinoma) and NCI-H358 (bronchioalveolar carcinoma). The results indicate that the presence and the position of the adamantyl acyl group or chlorine atom are the necessary requirement for antitumor activity of pyranone systems. Derivatives of kojic acid with either free (compounds 1 and 8) or acylated 5-OH group (compounds 2 and 9) have shown good-to-moderate activity (IC values ranging from 13.

Mannosylated N-aryl substituted 3-hydroxypyridine-4-ones: synthesis, hemagglutination inhibitory properties, and molecular modeling.

Structural alterations of the aglycon portions of α-mannosides influence their inhibitory potency toward type 1-fimbriated Escherichia coli. The aim of our work was to prepare and explore inhibitory properties of novel mannosylated N-aryl-substituted 3-hydroxypyridine-4-ones because they possess needed structural characteristics as possible FimH antagonists. Hemagglutination inhibitory tests showed that the examined 3-hydroxypyridine-4-one α-mannosides exhibited better inhibitory activity than methyl α-d-mannopyranoside used as a reference compound.