[Effectiveness of various combinations of chemoradiotherapy for children and adolescents with Hodgkin's disease].

The paper presents the results of a retrospective analysis of the chemoradiotherapy of 393 infant patients with Hodgkin's disease.

[Secondary malignancies in late periods after chemoradiotherapy for lymphogranulomatosis in children].

The incidence of secondary malignancies (SM) was studied in a population of 219 patients in late periods (3-29 years) after childhood and adolescence chemoradiotherapy for Hodgkin's lymphoma (HL). SMs were found in 15 (6.8%) patients.

[Efficiency of radiation or chemoradiation therapy for diffusely growing brainstem tumors in children].

Radiation or chemoradiation therapy was performed in 97 children with diffusely growing brainstem tumors. A reduction in the severity of neurological disorders was achieved in 92 (94.8%) patients.

[Radiotherapy for brain stem neoplasms in children].

The immediate and short-term results of radiotherapy of brain stem tumors in 24 children were evaluated. All the patients were able to sustain treatment due to adjuvant support with dehydrating and hormonal drugs, and beneficial clinical effect was recorded in 80%. However, MRT showed no decrease in tumor size.

[Radiotherapy of cerebellar medulloblastoma in children].

Out of 108 children with brain tumors, aged 3-15, receiving radiotherapy in 191-1997, cerebral medulloblastoma was identified in 37 (34%). After total or subtotal excision of tumor, the latter were given 4-12 cycles of polychemotherapy. The brain and spinal marrow was exposed to 30-35 Gy followed by aiming 50-55 Gy irradiation of posterior cranial fossa.

[Novel site-specific endonuclease from Acinetobacter species M strain].

Site-specific endonuclease R. AspMI was isolated and purified to apparent functional homogeneity from Acinetobacter species (strain M). The enzyme recognizes symmetrical DNA sequence 5'-AGG decreases CCT-3' and cleaves it at the site indicated by the arrow forming blind DNA ends.

[A new site-specific adenine DNA-methyltransferase from Bacillus species ST5].

The site-specific DNA-methylase M.BspST5I has been isolated from Bacillus species ST5 and purified to functional purity. M.

[A new site-specific endonuclease from Bacillus species ST5].

A site-specific endonuclease R.BspST5I has been isolated in a functionally pure state from the thermophilic strain of Bacillus species ST5. The enzyme recognizes sequence 5'-GCATC-3' on the DNA and splits it at a distance of five nucleotides from the 3'-end of the recognition site as well as at distances of nine or ten nucleotides at the complementary filament depending on the hydrolyzed sequence of the DNA.

[Site-specific endonuclease and methylase from thermophilic bacteria of Bacillus species IS4].

The site-specific endonuclease R . BspIS4I and methylase M . BspIS4I have been isolated and purified to functional purity from the thermophilic strain of Bacillus species IS4.

[Results of comprehensive treatment of lymphogranulomatosis in children of various age groups].

The efficacy of combined treatment of 176 children of different age has been analyzed. All the children suffered from Hodgkin's disease which was treated according to protocols COPP, MOPP, DVPP, +radiotherapy, maintenance chemotherapy. The response to the treatment got worse at the age of prepuberty and puberty, e.

[A new thermophilic strain of Bacillus coagulans--a producer of BcoK1 site-specific endonuclease].

The strain, producing new site-specific endonuclease BcoKI has been found at the screening of the thermophilic bacteria isolated from tobacco. A phenotype characteristic of the strain is given. It has been identified as a new strain Bacillus coagulans.

[Isolation and properties of site-specific endonuclease BspTS514I from the thermophilic bacteria Bacillus species TS514].

New site-specific endonucleases BspBS31I, BstBS32I, BspIS41, BstTS5I, BspTS514I were isolated from five thermophilic soil bacteria Bacillus sp. BS31, B. stearothermophilus BS32, Bacillus sp.

[The significance of studying phospholipids in the diagnosis of hypothyroidism].

Phospholipids and their fractions were examined in 85 patients with hypothyroidism of various severity grades in the state of decompensation. It was established that hypothyroidism is characterized by essential disorders of the phospholipid metabolism which occurs already at the initial stages of the disease advances with progression of its severity and is manifested in an increase of phosphatidylserine, lysophosphatidylcholine, sphingomyelin, phosphatidylethanolamine and reduction of phosphatidylcholine. Examination of phospholipids and their fractions is one of the important supplementary objective methods of diagnosis of hypothyroidism, especially, in young persons, a criterion of metabolic decompensation of the disease.