Publications by authors named "Zelina Dos Santos Freire"
Efficacy of oral fluralaner (Bravecto) against Tunga penetrans in dogs: A negative control, randomized field study in an endemic community in Brazil.
PLoS Negl Trop Dis
March 2022
The sand flea Tunga penetrans is one of the zoonotic agents of tungiasis, a parasitic skin disease of humans and animals. The dog is one of its main reservoirs. This negatively controlled, randomized, double-masked clinical trial evaluated the therapeutic and residual efficacy of fluralaner for treatment of dogs naturally infested with T.
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- Tungiasis, a public health issue in resource-poor areas, is primarily spread by the parasite Tunga spp., with dogs acting as significant hosts.
- A study of 40 infested dogs in northeastern Brazil found that most lesions (89.1%) were on paw pads, and younger dogs experienced more infestations, but dark pigmentation hindered visibility of lesions.
- Clinical signs included hyperemia, pain, and lameness, and targeting early-stage infections is crucial for effective control, emphasizing the need for ongoing preventive measures in affected communities.
The aim of the present study was to evaluate the in vitro effect of quercetin combined with ivermectin (IVM) on Haemonchus contortus larvae and adults with different resistance profiles and demonstrate the in vivo anthelmintic action of this combination when used in sheep naturally infected. The effect of combination was evaluated based on the analysis of the mean effective concentration (EC50) obtained for larvae using the larval migration inhibition test and for adults using the motility test on females. The tests with larvae and adults were conducted using isolates with different degrees of susceptibility to IVM (sensitive, intermediate and highly resistant).
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