Publications by authors named "Zelin Yun"
Article Synopsis
- Antiphospholipid syndrome (APS) is an autoimmune disease that primarily affects younger individuals, but diagnosing it in older patients (60+) can be challenging due to similarities with other thrombosis disorders.
- This study analyzed 161 APS patients, finding that those with elderly-onset APS had higher instances of stroke at diagnosis and more cardiovascular risk factors compared to younger patients.
- Results indicated that elderly-onset APS patients experienced significantly higher rates of mortality over 10 years, highlighting the importance of early recognition and management of their health conditions to improve outcomes.
[A unicenter real-world study of the correlation factors for complete clinical response in idiopathic inflammatory myopathies].
Beijing Da Xue Xue Bao Yi Xue Ban
April 2024
Article Synopsis
- A study analyzed the clinical characteristics and treatment responses of 635 patients with idiopathic inflammatory myopathies (IIMs) at Peking University Hospital from 2000 to 2023.
- Out of 518 patients who completed follow-ups, only 50% achieved a complete clinical response, with varying rates among different IIM subtypes like dermatomyositis and anti-synthetase syndrome.
- Factors associated with a lack of response included the subtype of myopathy, presence of interstitial lung disease, elevated liver enzymes, higher inflammatory markers, and lower CD4 T cell counts.
Antiphospholipid syndrome (APS) is a systemic autoimmune disease characterized by thrombosis and pregnancy morbidity with the persistent presence of antiphospholipid antibodies (aPLs). Although anticoagulation is the primary treatment for APS, it fails in approximately 20-30% of obstetric APS cases and more than 30% of thrombotic APS cases. Therefore, there is a need for new, targeted treatments beyond anticoagulants.
View Article and Find Full Text PDFObjective: Non-criteria antiphospholipid antibodies (aPLs) increase the diagnostic value for antiphospholipid syndrome (APS) and contribute to better recognition of seronegative APS (SNAPS). However, the clinical utility and the diagnostic value of non-criteria aPLs are inconsistent. This study aimed to investigate the prevalence and clinical significance of 7 non-criteria aPLs in a large APS cohort.
View Article and Find Full Text PDFArticle Synopsis
- Beads in optical tweezers align along the light path, making it hard to count them using bright-field microscopy, which complicates single-molecule force measurements.
- A new video processing method using normalized cross-correlation and image enhancement techniques enables real-time counting of trapped micro-objects, detecting changes in image similarity as beads enter the trap.
- This method can identify up to four beads individually and is effective even with the trap's slight movement, proving to be a sensitive and simple solution for monitoring changes in optical trapping experiments.