pH-Activatable NIR Hemicyanine for Mitochondria-Targeted Cancer Phototheranostics.

Photodynamic therapy (PDT) has garnered significant attention for cancer treatment due to its noninvasive nature, reduced drug resistance, and spatiotemporal controllability. However, traditional photosensitizers (PSs) face limitations such as severe systemic phototoxicity and shallow tissue penetration, which hinder the widespread clinical application of PDT. Capitalizing on the strong near-infrared (NIR) absorption and ease of structural modification of hemicyanine, we have designed a pH-activatable NIR hemicyanine PS (LET-15).

Large Scale Synthesis of Red-Emitting Quantum Dots for Efficient and Stable Light-Emitting Diodes.

It is known that large-scale synthesis of emitters affords colloidal quantum dot (CQD) materials with a great opportunity toward the mass production of quantum dot light-emitting diodes (QLEDs) based commercial electronic products. Herein, an unprecedented example of scalable CQD (> 0.5 kilogram) is achieved by using a core/shell structure of CdZnSe/ZnSeS/CdZnS, in which CdZnSe, ZnSeS, and CdZnS alloys are used as the inner core, transition layer and outermost shell, respectively.

Fabrication of Ultrafine L1-FePt-Based Magnetic Patterns Enabled by Single-Step Nanoimprint-Assisted Block Copolymer Self-Assembly.

The bit islands in magnetic patterns play a crucial role in advancing magnetic recording density, but the trade-off issues between miniaturization and scalable production are still challenging. Here we present a two-in-one technique of nanoimprint lithography (NIL)-assisted self-assembly using a specially engineered FePt-containing block copolymer (BCP), offering a simple one-step fabrication for L1-FePt bit-patterned media with high throughput. This method combines top-down NIL with bottom-up self-assembly to precisely control the ultrafine magnetic bits in the nanoscale patterns.

Exhaustive drainage versus fixed-time drainage for chronic subdural hematoma after one-burr hole craniostomy (ECHO): study protocol for a multicenter randomized controlled trial.

Background: Chronic subdural hematomas (CSDHs) are one of the most common neurosurgical conditions. The standard surgical technique includes burr-hole craniostomy, followed by intraoperative irrigation and placement of subdural closed-system drainage. The drainage is generally removed after 48 h, which can be described as fixed-time drainage strategy.

Ectopic Acsl6 Overexpression Partially Improves Isoproterenol-Induced Cardiac Hypertrophy In Vivo and Cardiomyocyte Hypertrophy In Vitro.

The increase in cardiac myocyte size is a critical issue in cardiac hypertrophy development. In this study, 61 differentially expressed genes between hypertrophic rats and normal controls were enriched in the positive modulation of fatty acid uptake, fatty acid metabolism and degradation, cardiac conduction, and the oxidation of carbohydrates and other processes. Acsl6 was significantly downregulated in hypertrophic rat and mouse hearts according to online data.

Star-Shaped ROMP Polymers Coated with Oligothiophenes That Exhibit Unique Emission.

A series of oligo(thiophene)-modified "soluble" star-shaped ring-opening metathesis polymerization (ROMP) polymers were prepared by sequential living ROMP of norbornene and a cross-linking agent using a molybdenum-alkylidene catalyst, followed by Wittig-type coupling for termination with oligo(thiophene) carboxaldehydes. The resultant star-shaped ROMP polymers displayed unique emission properties affected by the core size and arm repeat units as well as the kind of oligothiophene coated. The effects of the thiophene groups on photophysical properties of star-shaped/linear polymers were studied time-resolved fluorescence spectroscopy.

Effect of the Linking Group on the Thermoelectric Properties of Poly(Schiff Base)s and Their Metallopolymers.

As polymer-based thermoelectric (TE) materials possess attractive features such as light weight, flexibility, low toxicity and ease of processibility, an increasing number of conducting polymers and their composites with high TE performances have been developed in recent years. Up to date, however, the research focusing on the structure-performance relationship remains rare. In this paper, two series of poly(Schiff base)s with either C=C or C≡C linker and their metallopolymers were synthesized and doped with single-walled carbon nanotubes to evaluate how the linking groups affected the TE properties of the resulting composites.

Bioinformatics Analysis of the Expression of ATP Binding Cassette Subfamily C Member 3 (ABCC3) in Human Glioma.

Objective: To investigate the expression of the ABCC3 gene in human glioma and its correlation with the patient's prognosis.

Methods: The cancer genome atlas (TCGA) database was used to analyze the differential expression of the ABCC3 gene in human glioma. The STRING database was used to construct the protein-protein interaction (PPI) network of the ABCC3 gene coding protein.

One-pot synthesis of end-functionalised soluble star-shaped polymers by living ring-opening metathesis polymerisation using a molybdenum-alkylidene catalyst.

Precise synthesis of soluble star-shaped polymers has been achieved by adopting living ring-opening metathesis polymerisation (ROMP) using a molybdenum-alkylidene catalyst with sequential addition of norbornene and cross-linking agent; the method provides efficient one-pot synthesis of high molecular weight end-functionalised star-shaped polymers ( = >1.37 × 10) with more arms (branching) with rather low PDI values ( / = 1.17-1.

Inhibition of BET bromodomain attenuates angiotensin II induced abdominal aortic aneurysm in ApoE mice.

Background: Excessive degradation of extracellular matrix by matrix metalloproteinases (MMP) is the major pathological feature of abdominal aortic aneurysm (AAA). Suppression of extracellular matrix degradation attenuates AAA initiation and progression in preclinical models. In the present study, we wanted to test the effect of JQ1, a small chemical molecule that selectively targets bromodomain and extra-terminal domain (BET), on AngII induced AAA formation in ApoE mice.

TERT promoter mutated WHO grades II and III gliomas are located preferentially in the frontal lobe and avoid the midline.

The promoter region of telomerase reverse transcriptase (TERTp) and isocitrate dehydrogenase (IDH) have been regarded as biomarkers with distinct clinical and phenotypic features. Investigated the possible correlations between tumor location and genetic alterations would enhance our understanding of gliomagenesis and heterogeneity of glioma. We examined mutations of TERTp and IDH by direct sequencing and fluorescence in-situ hybridization in a cohort of 225 grades II and III diffuse gliomas.

Subgroup characteristics of insular low-grade glioma based on clinical and molecular analysis of 42 cases.

Although the classification of insular glioma has been established based on the anatomical location in order to facilitate personalized surgical resection, the diagnosis based on anatomical and functional characteristics becomes more complex when insular tumors extend into either the frontobasal brain region and/or the temporal lobe, as part of the limbic system. Moreover, prognosis of insular tumor resection is still controversial. Further analysis of subgroup characteristics of insular grade II gliomas based on clinical and molecular analysis is required to reliably determine patients' survival rates.

IL-8 up-regulates proliferative angiogenesis in ischemic myocardium in rabbits through phosphorylation of Akt/GSK-3β(ser9) dependent pathways.

Background: Therapeutic myocardial angiogenesis is an important compensatory mechanism in severely coronary stenosis. Previous studies demonstrated that interleukin-8 (IL-8) not only plays an important role in inflammation, but also a potent angiogenic factor through p38 mitogen-activated protein kinase (p38MAPK), nuclear factor-kappaB (NK-κB)-dependent pathway in carcinoma. Our study sought to investigate the effects of IL-8 on the angiogenesis and the underlying mechanism in the ischemic myocardium.

[Five-case report for transvenous epicardial pacemaker implantation via coronary sinus in patients after prosthetic tricuspid valve replacement].

Five patients after prosthetic tricuspid valve, who received pacemaker implantation via coronary sinus during Oct, 2011 and Jul, 2014, were enrolled. Pacemakers were implanted via coronary vein in 5 patients without complications. The stimulation thresholds keep stable and symptoms (such as short breath and fatigue) were disappeared during the follow-up.

Ring-tension adjusted ethylene polymerization by aryliminocycloheptapyridyl nickel complexes.

The stoichiometric reactions of 5,6,7,8-tetrahydrocycloheptapyridin-9-one (cycloheptapyridin-9-one) with various anilines lead to corresponding mixtures of 9-aryliminocycloheptapyridine and the isomeric 9-arylamino-5,6,7-trihydrocycloheptapyridine derivatives; these compounds further reacted with nickel dichloride to form 9-aryliminocycloheptapyridyl nickel chlorides, respectively. The new organic compounds were analyzed by the NMR measurements, and all the organic and complex compounds were characterized by the FT-IR spectroscopy and elemental analysis. In addition, the molecular structures of representative nickel complexes and , determined by means of single-crystal X-ray diffraction, were found to be binuclear dimers with distorted square-pyramidal geometry around the nickel centers.

Meta-analysis Identifies Serum C-Reactive Protein as an Indicator of Atrial Fibrillation Risk After Coronary Artery Bypass Graft.

A meta-analysis-based study was conducted to examine the clinical value of serum C-reactive protein (CRP) levels in predicting postoperative atrial fibrillation (POAF) in patients with coronary artery disease (CAD) who underwent coronary artery bypass graft. Computer-based search of scientific literature databases was performed to identify relevant studies in strict accordance with our inclusion and exclusion criteria. Data extracted from the selected studies were used to perform meta-analysis using the STATA 12.

Protective effect of microRNA-30b on hypoxia/reoxygenation-induced apoptosis in H9C2 cardiomyocytes.

We examined the protective role of microRNA-30b (miR-30b) in ischemia-reperfusion (I/R)-induced injury in rat H9C2 cardiomyocytes. H9C2 cells were subjected to hypoxia-reoxygenation (H/R) treatment to simulate ischemia-reperfusion (I/R) injury. H9C2 cells were divided into: vehicle control (VC) group; scrambled inhibitors (INC) group; scrambled mimics (MNC) group; H/R+VC group; H/R+INC group; H/R+mimics group.

Serum fetuin-A levels in patients with cardiovascular disease: a meta-analysis.

Background: Fetuin-A (FA) suppresses arterial calcification, promotes insulin resistance, and appears to be elevated in patients with cardiovascular diseases (CVD), but the data is still inconsistent. To clarify the correlation between serum FA levels and the presence and severity of CVDs, we performed this meta-analysis.

Method: Potential relevant studies were identified covering the following databases: PubMed, Embase, Web of Science, Cochrane Library, CISCOM, CINAHL, Google Scholar, China BioMedicine (CBM), and China National Knowledge Infrastructure (CNKI) databases.

[Effects of high plating densities on in vitro and in vivo differentiation capability of immortalized human mesenchymal stem cells].

Objective: To determine whether different cell plating densities could influence the potential differentiation of immortalized human mesenchymal stem cells (hMSC-TERT).

Methods: Extensive characterization was performed for two independent cell lines derived from parental hMSC-TERT cell line based on different plating densities during expansion in culture: 1: 2 (hMSC-TERT2) and 1: 20 (hMSC-TERT20). Their adipocytic, osteogenic, neuronal differentiation potential in vitro and multidirectional differentiation potential in vivo were analyzed by immunohistochemistry for pathologic tissue markers.

[Association between differentiation potential of immortalized human mesenchymal stem cells and cluster of differentiation antigens].

Objective: To explore the relationship between multi-differentiation potential of monoclonal immortalized human mesenchymal stem cells (hMSC-TERT) in vivo and their cluster of differentiation antigens (CD).

Methods: Monoclonal hMSC-TERT were isolated using limiting dilution. Direct immunofluorescence staining flow cytometry was used to detect the cluster of differentiation antigens (CD44, CD45, CD105) of these cell lines.

Cyclotrimerization of terminal alkynes catalyzed by the system of NiCl2/Zn and (benzimidazolyl)-6-(1-(arylimino)ethyl)pyridines.

An effective regioselective cyclotrimerization of terminal alkynes is achieved by the direct utilization of NiCl2·6H2O, Zn, and 2-(benzimidazolyl)-6-(1-(arylimino)ethyl)pyridine in one step under ambient temperature.

CuCl-catalyzed ortho trifluoromethylation of arenes and heteroarenes with a pivalamido directing group.

The CuCl catalyzed direct trifluoromethylation of sp(2) C-H bonds has been realized, using the Togni reagent as the CF3 source. This reaction achieves the goal of regio-selectively converting C-H into C-CF3 with ecological and readily available starting materials.

Stent-jail technique in endovascular treatment of wide-necked aneurysm.

Aim: To describe a reconstructive technique using single stent for wide-necked aneurysms.

Material And Methods: This technique was described as stent-jail technique consisting of the aneurismal catheterization before the deployment of a self-expandable stent across the aneurysm neck. Following the deployment of the stent, embolization coils were delivered with the microcatheter positioned within the aneurysm dome and wedged between the stent and the aneurysm dome.

[Associativity between differentiation potential and VEGF secretory capability of immortalized human mesenchymal stem cells].

Objective: To investigate the multi-differentiation potential and VEGF secretory volume of monoclonal immortalized human mesenchymal stem cells (hMSC-TERT) and to determine the relationship between them.

Methods: Monoclonal hMSC-TERT were isolated using limiting dilution. The growth curves of them were detected by method of MTT.

[Effect of monoclonal or different cell seeding densities on the differentiation potential of immortalized human mesenchymal stem cells in vitro and in vivo].

Objective: To determine whether monoclonality or different cell seeding densities could influence the differentiation potential of immortalized human mesenchymal stem cells (hMSC-TERT) and to find an effective cultural method of hMSC-TERT in vitro.

Methods: From the parental hMSC-TERT cell line, we derived 30 monoclonal cell lines and two independent cell lines based on different plating densities during expansion in culture. Their adipocytic, osteogenic, neuronal differentiation potential in vitro and multidirectional differentiation potential in vivo were analyzed by immunohistochemistry for pathologic tissue markers.