Glassy carbon electrodes modified with graphitic carbon nitride nanosheets and CoNiO bimetallic oxide nanoparticles as electrochemical sensor for Sunitinib detection in human fluid matrices and pharmaceutical samples.

A sophisticated electrochemical sensor is presented employing a glassy carbon electrode (GCE) modified with a novel composite of synthesized graphitic carbon nitride (g-CN) and CoNiO bimetallic oxide nanoparticles (g-CN/CoNiO). The sensor's electrocatalytic capabilities for Sunitinib (SUNI) oxidation were demonstrated exceptional performance with a calculated detection limit (LOD) of 52.0 nM.

Electrochemical Detection of Melphalan in Biological Fluids Using a g-CN@ND-COOH@MoSe Modified Electrode Complemented by Molecular Docking Studies with Cellular Tumor Antigen P53.

Melphalan (Mel) is a potent alkylating agent utilized in chemotherapy treatments for a diverse range of malignancies. The need for its accurate and timely detection in pharmaceutical preparations and biological samples is paramount to ensure optimized therapeutic efficacy and to monitor treatment progression. To address this critical need, our study introduced a cutting-edge electrochemical sensor.

Hydrolytic enzyme modified magnetic nanoparticles: An innovative and green microextraction system for inorganic species in food samples.

In the presented study, the usability of hydrolytic enzyme immobilized magnetic nanoparticles as an extraction agent for the microextraction of metal ions from food samples was investigated. α-amylase modified magnetic carbon nanotubes (α-amylase-FeO/MWCNTs) was used as an extraction agent for direct microextraction of trace arsenic from food sample phase into liquid phase medium prior to its ICP-MS determination. In extraction studies using hydrolytic enzymes, it is impossible to recover the free soluble enzyme after extraction without losing its activity.

Heavy metal contents of play dough, face and finger paint samples sold in turkish markets.

Lead, cadmium, nickel, manganese, cobalt and copper contents of some play dough, face and finger paint samples were determined by using a new solid phase extraction method which has been developed by using multi-walled carbon nanotube with patent blue (V) sodium salt to selectively separate and preconcentrate these metal ions. Flame atomic absorption spectrometry was used to determine the metal ions. Analytical parameters affecting the complex formation and solid phase extraction performance such as pH, the amount of ligand and volume of sample solution were investigated.