Publications by authors named "Zeliang Shen"

Salivary gland neoplasms (SGNs) represent a group of human neoplasms characterized by a remarkable cytomorphologic diversity, which frequently poses diagnostic challenges. Accurate histologic categorization of salivary tumors is crucial to make precise diagnoses and guide decisions regarding patient management. Within the scope of this study, a computer-aided diagnosis model using Vision Transformer (ViT), a cutting-edge deep learning model in computer vision, has been developed to accurately classify the most prevalent subtypes of SGNs.

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Objectives: To investigate the importance of fatty acid oxidation (FAO)-related genes in predicting the progression and prognosis of head and neck squamous cell carcinoma (HNSCC).

Methods: The FAO-related gene prognostic model was established employing Cox regression analyses, during which accuracy and sensitivity of the gene model were evaluated in The Cancer Genome Atlas (TCGA) internal testing and Gene Expression Omnibus (GEO) external validation cohorts. Ultimately, hub genes were identified among 13 model genes using STRING and Cytoscape, with preliminary validation carried out through immunohistochemistry.

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Studies suggest that the expression of glutamate decarboxylase 1 (GAD1), γ-aminobutyric acid (GABA), and GABA receptors are involved in tumor progression. However, the underlying mechanisms of high expression and potential functions of GAD1 and GABA in oral squamous cell carcinoma (OSCC) are not known. In this study, we found that the expressions of GAD1 and GABA were considerably increased in OSCC samples, which were closely associated with clinical stage and lymph node metastasis.

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Article Synopsis
  • The study aimed to investigate the clinicopathological features of maxillofacial granular cell tumors (GCT) using immunohistochemical staining to assist in diagnosis.
  • Researchers analyzed seven cases of GCT, focusing on their microscopic features and tested various markers (like S-100 and CD68) to understand their characteristics better.
  • The results showed that GCT tumors have a unique histological structure, and the immunohistochemical markers can aid in diagnosis, suggesting a positive prognosis after surgical removal, as none of the follow-up cases showed recurrence.
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Partial discharge (PD) usually reflects failures and potential hazards of equipment, so PD detection is important to protect the power system. The most reliable method now is the pulse current method (PCM), but the device of PCM is large and hard to carry. Ultraviolet (UV) pulse detection is another method to detect PD, which has a high precision, strong anti-interference ability, and a long effective distance.

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