Publications by authors named "Zeliang He"

As a class of readily available and multifunctional building blocks, the chemistry of 4-alken-2-ynyl carbonates remains to be explored. Presented herein is a palladium-catalysed cascade transformative reaction between 4-alken-2-ynyl carbonates and -functionalised activated alkenes. Achiral 1,1-bisalkyl-4-alken-2-ynyl carbonates undergo highly regioselective propargylic substitution with -hydroxyphenyl-tethered activated alkenes, and an auto-tandem vinylogous addition, unusual central-carbon Tsuji-Trost alkylation, protonation and β-H elimination process is followed to furnish fused and spirocyclic frameworks with high structural complexity.

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Excessive scar formation such as hypertrophic scars and keloids, resulting from trauma or surgical procedures, present a widespread concern for causing disfigurement, discomfort, and functional limitations. Macrophages play pivotal roles in maintaining tissue homeostasis, orchestrating tissue development, repair, and immune responses, and its transition of function and phenotype plays a critical role in regulating the balance between inflammation and tissue regeneration, which is central to cutaneous scar formation. Recent evidence suggests the involvement of Sonic Hedgehog (SHH) in the induction of anti-inflammatory M2-like macrophage phenotypes within tumor microenvironments.

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Here we report a three-component auto-tandem reaction of 1,3-enyne-tethered carbonyls, organoboronic reagents, and suitable nucleophiles catalyzed by palladium, proceeding through consecutive intramolecular vinylogous addition, Suzuki coupling, and allylic alkylation. This process exhibited high chemo- and regioselectivity with 1,3,4-trifunctionalization of the 1,3-enyne motif, and a wide range of 2-chromenes, 1,2-dihydroquinolines, benzo[]oxepines, 1,7-annulated indoles, and other frameworks were efficiently constructed in fair to good yields and / selectivity.

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Interventions for extrinsic aging can be implemented, but these must address photoaging, which is the primary cause of extrinsic aging. Pigmentation due to photoaging depends on the duration and intensity of sun exposure. This study investigated the relationship between adipose-derived mesenchymal stem cells (ASCs) and photoaging pigmentation, and the underlying mechanism of action by establishing a photoaging pigmentation model using various treatments and exposure options in a guinea pigs.

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A cascade assembly between isatin-derived Morita-Baylis-Hillman carbonates and -hydroxybenzylideneacetones has been developed under the relay catalysis of Pd(PPh) and DBU, affording a spectrum of 1,2,3,4-tetrahydrodibenzo[,]furan architectures incorporating a spirooxindole motif in moderate to good yields with excellent diastereoselectivity. The fused indole analogues were similarly furnished by employing the benzylideneacetones having an -TsNH group.

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Hypertrophic scarring (HS) is a dermal fibroproliferative disorder characterized by excessive deposition of collagen and other extracellular matrix components. The aim of this study is to explore crucial long noncoding RNAs (lncRNAs) and circular RNAs (circRNAs) associated with HS and provide a better understanding of the molecular mechanism of HS. To investigate the lncRNA, circRNA and mRNA expression profiles, we performed RNA sequencing of human HS and normal skin tissues.

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HOTTIP functions as an independent biomarker in multiple cancers. However, the role of HOTTIP in hepatocellular carcinoma (HCC) remains unclear. In this study, we sought to investigate the HOTTIP expression in HCC and normal liver.

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Synopsis of recent research by authors named "Zeliang He"

  • - Zeliang He's recent research primarily focuses on the cellular and molecular mechanisms involved in scar formation and skin regeneration, with an emphasis on the role of macrophages and signaling pathways such as Sonic Hedgehog (SHH) in promoting tissue repair and anti-inflammatory responses.
  • - His studies explore innovative approaches using adipose-derived mesenchymal stem cells to address photoaging-related pigmentation, and investigate the underlying mechanisms affecting skin aging and healing processes.
  • - Additionally, He has delved into the biochemical synthesis of complex organic frameworks and has identified key long noncoding RNAs associated with hypertrophic scars, utilizing RNA sequencing to enhance understanding of the molecular basis underlying this condition.

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