Spontaneous collapse of an iris stromal cyst in a young child.

A 4-month-old girl was referred for evaluation of an anterior chamber cyst in the left eye. Examination under anesthesia (EUA) revealed a large iris stromal cyst in the anterior chamber involving the angle and the pupillary border, with touch of the corneal endothelium and anterior lens capsule. Intraocular pressure was normal.

Artificial intelligence for ocular oncology.

Purpose Of Review: The aim of this article is to provide an update on the latest applications of deep learning (DL) and classical machine learning (ML) techniques to the detection and prognostication of intraocular and ocular surface malignancies.

Recent Findings: Most recent studies focused on using DL and classical ML techniques for prognostication purposes in patients with uveal melanoma (UM).

Summary: DL has emerged as the leading ML technique for prognostication in ocular oncological conditions, particularly in UM.

Indications for Fine Needle Aspiration Biopsy of Posterior Segment Intraocular Tumors.

Purpose: To define 4 indication categories of fine needle aspiration biopsies (FNABs) of solid intraocular tumors and describe the differences among the patients, tumors, and results of biopsy in these 4 indication categories.

Methods: Retrospective descriptive analysis of 880 FNABs of a solid intraocular tumor of the posterior ocular segment performed by in the authors' ocular oncology practice during the period July 1980 through July 2014.

Results: FNABs were performed as a separate procedure in 372 cases (42.

Managing the consequences of aggressive conservative treatment for refractory retinoblastoma with vitreous seeding.

A 4 year-old girl with bilateral, non-familial retinoblastoma (RB) was referred to our care after primary enucleation OS and active tumor OD refractory to multiple therapies (intravenous chemotherapy, laser/cryotherapy, and I-125 plaque radiotherapy). Vitreous seeding OD, initially controlled by several sessions of Ophthalmic Artery Infusion Chemotherapy (OAIC) and periocular chemotherapy, recurred shortly thereafter. The patient underwent intravitreal (IVit) Melphalan injections achieving tumor control despite the concurrent development of keratopathy, pupillary synechiae, cataract, and necrosis of the inferior fornix and the adjacent orbital fat, all secondary to the treatments administered.

Prognostic implications of cytopathologic classification of melanocytic uveal tumors evaluated by fine-needle aspiration biopsy.

Purpose: Determine whether cytopathologic classification of melanocytic uveal tumors evaluated by fine-needle aspiration biopsy (FNAB) is a significant prognostic factor for death from metastasis.

Methods: Retrospective analysis of cases of clinically diagnosed uveal melanoma evaluated by fine-needle aspiration biopsy from 1980 to 2006. Main outcome evaluated was death from metastasis.

[Margin reflex distance measure by computerized image processing in rigid contact lens wearers].

Purpose: To measure the MRD (margin reflex distance) in rigid contact lens wearers and controls by a new method, based on computerized image processing.

Method: The patients were selected from the Contact Lens Sector of the Ophthalmology Service at the "Complexo Hospitalar Santa Casa de Porto Alegre", and they were divided into two groups: the first was formed of rigid contact lens wearers (63 eyes) and the second of patients without previous history of contact lens wear (30 eyes). All patients were photographed with a digital camera (Nikon Coolpix 4300).

The role of c-kit and imatinib mesylate in uveal melanoma.

Background: Uveal melanoma (UM) is the most common primary intraocular tumor in adults, leading to metastasis in 40% of the cases and ultimately to death in 10 years, despite local and/or systemic treatment. The c-kit protein (CD117) is a membrane-bound tyrosine kinase receptor and its overexpression has been observed in several neoplasms. Imatinib mesylate is a FDA approved compound that inhibits tyrosine quinase receptors, as well as c-kit.