Publications by authors named "Zelenetskaia V"

Gonadotropic function was investigated and the diagnostic value of the test with luteinizing hormone releasing factor (LHRF) was assessed in patients with polycystic ovaries. For this purpose a 100 micrograms dose of LHRF was intravenously jet injected to 10 patients with nonspecific polycystic ovaries. Levels of luteinizing and follicle stimulating hormones (LH and FSH) were determined before the injection and 15, 30, 60, 90 or 120 minutes after it.

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An increase in the prolactin basal level was detected in 8 out of 50 patients with ovarian polycystosis. A test with TRH and a simultaneous determination of the levels of prolactin, TTH, T3, T4 were used in 25 patients, of them a hyperergic reaction of prolactin to TRH was detected in 5. A correlation analysis of function of the thyroid was performed.

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The determination of corticosterone and aldosterone levels in the peripheral blood of rats and a cortisol level in the blood of guinea pigs by a radioimmunoassay following the administration of dioxydin (1,4-N-oxide 2 2,3-dioxymethylquinoxaline) has shown that it produces an inhibiting effect upon the secretion of corticosteroid hormones in animals with a diverse direction of their biosynthesis. There is a dose dependence of the effect detected. Substitution therapy with corticosteroids cuts short adrenal insufficiency caused by dioxydin.

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The content of aldosterone and renin activity were examined together with the determination of progesterone, estradiol, gonadotropins and prolactin in the blood of 39 women with idiopathic edemas and in 15 normal women in different phases of menstrual cycle. Women with idiopathic edemas showed a number of hormonal deviations: absolute and relative hyperaldosteronism, particularly demonstrable in the ortho-position, impairment of physiological stability between aldosterone levels in the luteic and folliculin phases; a decrease in progesterone level in the luteic phase; a decrease in the absolute amount of estrogens in the folliculin phase and relative hyperestrogeny in the luteic one; an increase in prolactin content in the early folliculin phase in a considerable number of patients (50%). It is assumed that deviations described might be involved in the formation of edemas.

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As a result of the study of the LH, FSH, prolactin and testosterone content in the blood of patients with androgen-producing ovarian tumors and LH-tumor tissue binding in vitro, it was detected that the gonadotropic hormone content may be low, normal and high. The testosterone level does not correlate with LH, FSH and prolactin concentration. LH-receptor binding is disturbed in the androgen-producing tumor tissue and hormone presence is not necessary to maintain androgen secretion by the tumor.

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Circadian changes in the corticosteroid, testosterone, and ACTH content in the blood plasma were examined to monitor the suppressant effect of glucocorticoids on adrenocortical and hypophyseal functions during administering glucocorticoid drugs to patients with congenital adrenocortical dysfunction. The daily dose of glucocorticoids was given in two intakes according to the two schemes: scheme 1 included the drug intake in the morning and in the afternoon, scheme 2 in the morning and in the evening. The effect of glucocorticoid therapy on the pattern of the circadian rhythm and the absolute corticosteroid and testosterone content was shown to depend on the time of the drug intake.

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125I-LH binding by interstitial tissues of 33 polycystic ovaries was studied comparatively to their androgenic activity. It was shown that the disorder of LH binding by the ovary interstitial tissue is peculiar to the polycystic ovaries in ovarian hyperandrogeny. Changes in 125 I-LH binding by the interstitial tissue and the ovary androgenic activity are closely correlated.

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The plasma LH content was studied in 22 patients aged 1 to 16 years, suffering from cryptorchidism and anorchism, by radioimmunoassay. The gonad androgenic function was evaluated according to the plasma testosterone level under conditions of the functional test with chorionic gonadotrophin. Considerable polymorphism in the gonad function change was found: in 45.

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Investigation of the therapeutic efficacy of menopause gonadotropin (MPG), made in the USSR, in patients with hypogonadotropic hypogonadism demonstrated MPG to possess the FSH-activity. In a number of patients with hypogonadotropic hypogonadism MPG treatment led to the occurrence of the ovular menstrual cycle, confirmed both clinically and by hormonal studies. But sometimes MPG proved to be ineffective, this pointing to the necessity of individual choice of a drug dose and the number of therapeutic courses.

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Aldosterone and progesterone content and renin activity were studied by the radioimmunological method in women with the idiopathic edema syndrome and in healthy women in various phases of the menstrual cycle. The most significant differences were revealed in the luteinic phase of the cycle. A parallel elevation of the renin activity and of the aldosterone level against the background of a high progesterone level occurred in healthy women at this phase.

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Androgenic function of the testes was studied in children and adolescents suffering from cryptorchism. Information on this problem is scant and controversial. The most sensitive radioimmunological methods of testosterone determination and functional test with chorionic gonadotropin were used in this work.

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The authors studied the LH-125I binding by the interstitial tissue of 12 polycystic ovaries obtained after wedge resection of the ovaries in 6 patients. Prior to the operation the patients were differentiated by the LH, FSH, prolactin, and testosterone level. Disturbances of LH125I binding were revealed in the interstitial tissue of polycystic ovaries.

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The authors studied the content of gonadotropins and testosterone in the blood; functional condition of the hypothalamus-hypophysis-ovarian system was characterized in patients with ovarian hyperandrogenia by using the klomiphen test. Testosterone level in all the patients and prolactin level in 70% of the patients proved to exceed the normal values, wheras the LH level could be low, normal or high. With klomiphen test it was shown that both the gonadotropin and estrogen levels rose against the background of action of the preparation; as to testosterone level--it remained unchanged.

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On the basis of analysis of a case of a combination of mixed dysgenesia of the ovaries with stromal thecomatosis and the clinical picture of the virile syndrome a conclusion was drawn that a) hypertestosteronemia was in such cases connected with the presence in the dysgenetic ovary and the connective tissue band of epitheliod cells forming the foci of stromal thecomatosis, and b) that the appearance of stromal thecomatosis failed to depend on the presence of the follicular apparatus; apparently cells of the interstitial tissue of the cortical layer of the ovaries serve as its source.

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The authors present the results of determination of the testosterone level in the blood by the method of competitive fixation by proteins under conditions of a functional test with the depression of the adrenal cortex function with dexamethazone and stimulation of the ovarian function with choriogonin against this background in patients with the virile syndrome of ovarian genesis. Three groups of patients with the ovarian hyperandrogenia were distinguished. Changes in the blood testosterons level under the test conditions confirmed objectively the ununiformity of of this syndrome and permitted one to characterize the hormonal activity of the androgen-producing structures of the ovaries and their sensitivity to choriogonin stimulation in patients of different groups.

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The paper presents, the data on the treatment of 74 patients with anovular conditions varying by the pathogenesis, with klomiphen. Three groups of patients were distinguished depending on the therapeutic efficacy: the 1st group with a complete clinical effect, the 2nd group with a partial clinical effect, and the 3rd group - without any effect. In comparing the therapeutic efficacy with the data of gonadotropin examination it was revealed that the outcome of the therapy failed to depend on the initial LH and FSH level.

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