Staphylococcus aureus blocks host autophagy through circSyk/miR-5106/Sik3 axis to promote progression of bone infection.

With the rapid increase in the number of implant operations, the incidence of bone infections has increased. Methicillin-resistant Staphylococcus aureus (S. aureus) and other emerging fully drug-resistant strains make the management of bone infections even more challenging.

Mechanisms of promoting the differentiation and bone resorption function of osteoclasts by Staphylococcus aureus infection.

Bone infection is a common and serious complication in the field of orthopedics, which frequently leads to excessive bone destruction and fracture nonunion. Staphylococcus aureus (S. aureus) infection affects bone cell function which, in turn, causes bone destruction.

YgiM may act as a trigger in the sepsis caused by through the membrane-associated ceRNA network.

Sepsis is one of the diseases that can cause serious mortality. In , an inner membrane protein YgiM encoded by gene can target the eukaryotic peroxisome. Peroxisome is a membrane-enclosed organelle associated with the ROS metabolism and was reported to play the key role in immune responses and inflammation during the development of sepsis.