Publications by authors named "Zelalem Asmare"

Background: Intestinal parasitic infections are a significant public health concern, especially among food handlers, who can transmit these infections to the public through food preparation and handling. This systematic review and meta-analysis aimed to determine the pooled prevalence and associated factors of intestinal parasitic infections among food handlers in the East African region.

Methods: A systematic review and meta-analysis on intestinal parasitic infections among food handlers involved a comprehensive search across various databases, including Scopus, PubMed, ScienceDirect, Google Scholar, and the institution's library registers.

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Background: TB is a leading infectious disease globally, with war and displacement significantly increasing its burden. In Ethiopia, ongoing conflict and displacement have worsened health conditions, yet data on TB prevalence and resistance remain scarce. This study aimed to determine the prevalence of TB, rifampicin-resistant TB (RR-TB), and associated factors among presumptive TB patients in hospitals during the ongoing crisis.

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Background: Diabetes mellitus (DM) is a metabolic abnormality affecting 537 million people worldwide. Poor glycemic control, longer duration, and poor medication adherence increased the risk of DM complications. Comprehensive evidence on the pooled prevalence of microvascular complications in DM patients in Ethiopia is not available.

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Article Synopsis
  • Malaria is a significant global health issue caused by the Plasmodium genus, with drug resistance, particularly to chloroquine in P. vivax and P. falciparum, being a pressing concern in endemic regions of Africa.
  • The study aimed to assess the prevalence of molecular markers indicating chloroquine resistance in malaria parasites across East Africa through a systematic review and meta-analysis of relevant studies.
  • A total of 20 studies were analyzed, focusing on key molecular markers associated with chloroquine resistance, ultimately providing insight into the prevalence of these markers in malaria parasites.
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Background: The high levels of antimicrobial consumption in hospitals contribute to the occurrence of antimicrobial resistant bacteria. Antimicrobial resistant bacteria and sub-lethal concentrations of antimicrobial metabolites can end up in hospital wastewater which can spread to the environment and to the community. However, information on the resistance profile of bacteria isolated from environments is not well studied.

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Article Synopsis
  • The coronavirus disease 2019 (COVID-19) is caused by the SARS-CoV-2 virus, which has led to a global pandemic and is known for its single-stranded RNA structure.
  • This review aims to analyze recent research on the epidemiology, evolution, and vaccine development related to SARS-CoV-2 variants, using data collected from literature published between 2019 and 2023.
  • Various variants of SARS-CoV-2 have emerged throughout the pandemic, categorized by the World Health Organization into two main groups: variants of interest and variants of concern, with notable strains including Alpha, Beta, Gamma, Delta, and Omicron, emphasizing the need for continuous monitoring and research.
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Article Synopsis
  • A systematic review and meta-analysis was conducted to estimate the prevalence of pulmonary tuberculosis (PTB) among key and vulnerable populations (KVPs) in hotspot regions of Ethiopia, despite a global decline in TB incidence.
  • The analysis included 34 articles, with methods involving data recorded and analyzed using STATA 17.0, assessing prevalence rates by various group settings and publication years.
  • The findings estimated a pooled PTB prevalence of 11.7% in hotspot settings, with specific prevalence rates for different KVPs: prison inmates (8.8%), university students (23.1%), refugees (28.4%), and others, highlighting significant vulnerability among these groups.
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Article Synopsis
  • - The study investigates the prevalence of carbapenem-resistant gram-negative bacteria that cause neonatal sepsis in African newborns, as this issue is a growing concern globally.
  • - A total of 36 research studies were analyzed, revealing a combined prevalence rate of 30.34% for carbapenem resistance among these bacteria in Africa.
  • - Specifically, A. baumannii and Pseudomonas species showed high resistance rates, with 45.9% and 43.0% prevalence, respectively, indicating a significant public health challenge.
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Background: Antimicrobial-resistant (AMR) bacterial infection is a significant global threat to the healthcare systems. Pseudomonas aeruginosa, the leading infectious agent in the healthcare setting is now one of the major threats due to AMR. A comprehensive understanding of the magnitude of AMR, particularly highly public health important pathogens such as P.

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Malaria and schistosomiasis are infectious diseases that cause hematological profiles abnormalities. Malaria and co-infection causes exacerbation of health consequences and co-morbidities. The aim of this study was to assess the selected hematological profiles among malaria and co-infected patients at Dembiya Selected Health Institutions.

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Background: Antimicrobial resistance (AMR) is a serious threat to global health systems. is a major cause of urinary tract infections (UTIs). Understanding the AMR patterns of uropathogenic (UPEC) is crucial for effective public health interventions worldwide.

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Background: Catheter-associated urinary tract infections (CAUTIs) account for the majority of device-associated healthcare-acquired infections with significant morbidity and mortality worldwide. In developing countries with limited resources, the burden of CAUTI have substantial burden owing to the lack of well-organized infection prevention and control. Although there are studies in African countries, the magnitude of CAUTI is inconsistent.

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Malaria and schistosomiasis are infectious diseases that cause coagulation disorders, biochemical abnormalities, and thrombocytopenia. Malaria and Schistosoma mansoni co-infection cause exacerbations of health consequences and co-morbidities.This study aimed to compare the effect of malaria and Schistosoma mansoni co-infection and malaria infection on selected biochemical and coagulation profiles, and platelet count.

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Background: Catheter-associated urinary tract infections (CAUTIs) due to multidrug-resistant Gram-negative bacilli (GNB) is a common concern globally. Investigating the incidence of CAUTI and associated antibiotic resistance has paramount importance from the health care associated infections perspective. This study therefore assessed the incidence of CAUTIs due to GNB and the production of extended-spectrum beta-lactamase (ESBL) and carbapenemase among inpatients in specialized hospitals of Northwest, Ethiopia.

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