Publications by authors named "Zejun Fan"
Article Synopsis
- Cell encapsulation technology faces challenges with existing methods; microfluidics can harm cells, while conventional electrospray suffers from instability and breakage at high throughput.
- A new superimposed electric field (SEF)-enhanced electrospray method improves stability and biocompatibility, allowing for fast production of around 300 core-shell capsules per second.
- This method leads to significant advancements, such as increasing iPSC growth by 92 times compared to traditional cultures and creating liver capsules for modeling liver diseases, showing promise for clinical applications like transplantation and drug screening.*
Article Synopsis
- The regeneration of hierarchical osteochondral units is complicated due to challenges in directing mesenchymal stem cells (MSCs) to differentiate into cartilage and bone.
- The study introduced gelatin-based microcryogels made with hyaluronic acid (HA) and hydroxyapatite (HYP) to promote cartilage (CH-Microcryogels) and bone (OS-Microcryogels) regeneration through self-assembly into osteochondral organoids.
- Results showed that these microcryogels were effective in promoting chondrogenic and osteogenic differentiation, reduced inflammation, and successfully regenerated osteochondral units in canine models, highlighting a promising new strategy for tissue engineering.
Meniscus injuries, a common joint disease caused by long-term wear, trauma and inflammation, usually cause chronic dysfunction and pain in the joint. Current clinical surgeries mainly aim to remove the diseased tissue to alleviate patient suffering instead of helping with meniscus regeneration. As an emerging treatment, stem cell therapy has been verified to facilitate meniscus regeneration effectively.
View Article and Find Full Text PDFAllium mongolicum Regel (A. mongolicum) is a perennial and xerophytic Liliaceous allium plant in high altitude desert steppe and desert areas. Feeding A.
View Article and Find Full Text PDFInterleukin (IL)-11 is a multifunctional cytokine that exerts a series of important immunomodulatory effects and exists in many tissues and cells. A 1106-bp nucleotide sequence representing the complete cDNA of IL-11 was obtained from large yellow croaker (Larimichthys crocea), containing an open reading frame (ORF) of 603 bp encoding for 200 amino acids (aa). The predicted LcIL-11 protein included a 12aa signal peptide and a conserved IL-11 domain.
View Article and Find Full Text PDFFish is highly affected by many environmental stresses such as temperature and invasive infection. The extracellular signal-regulated kinase (ERK) pathway, part of the mitogen-activated protein kinase (MAPK) family, is found to act as crucial mediators for cell differentiation, proliferation and cell response to various stresses. In the present study, ERK2 (LcERK2) and ERK5 (LcERK2) were cloned and characterized from large yellow croaker, Larimichthys crocea.
View Article and Find Full Text PDFToll-like receptor 2 (TLR2) plays an important role in innate immune responses. Here we describe the isolation and characterization of the full-length cDNA sequence of toll-like receptor 2 in large yellow croaker Larimichthys crocea (LcTLR2). The LcTLR2 cDNA contains a 5'-terminal untranslated region (5'-UTR) of 135 bp, an open reading frame (ORF) of 2478 bp encoding a polypeptide of 825 amino acid residues and a 3'-UTR of 50 bp.
View Article and Find Full Text PDFThe interferon regulatory factor (IRF)3 and IRF7 are considered to play essential roles in innate immune system's antiviral responses. In this report, the full-length cDNA and genomic structure and immune response characterizations of IRF3 and IRF7 were investigated in large yellow croaker, Larimichthys crocea. The full-length cDNA of L.
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