Dual-ratiometric fluorescence probe for viscosity and hypochlorite based on AIEgen with mitochondria-targeting ability.

Viscous microenvironments are ubiquitous in living organisms. An oxidative stress attack could cause the fluctuation of lymph or blood viscosity, which is closely related to many common diseases. However, the dual-function detection of reactive oxygen species and viscosity is still ineffective due to design defects.

Multimodal magnetic resonance imaging analysis in the characteristics of Wilson's disease: A case report and literature review.

Wilson's disease (WD) is an inherited disorder of copper metabolism. Multimodal magnetic resonance imaging (MRI) has been reported to provide evidence of the extent and severity of brain lesions. However, there are few studies related to the diagnosis of WD with multimodal MRI.

Dysphasia is associated with diffusion-weighted MRI abnormalities in patients with transient neurological symptoms.

Background: The clinical characteristics of diffusion-weighted imaging (DWI) abnormalities after transient neurological symptoms are of great significance for the early diagnosis and urgent intervention of transient ischemic attack (TIA). This study was aimed to investigate the clinical characteristics associated with acute DWI lesions in transient neurological symptoms.

Methods: We retrospectively recruited 302 patients with transient neurological symptoms.

Sunlight and UV driven synthesis of Ag nanoparticles for fluorometric and colorimetric dual-mode sensing of ClO.

A photo-responsive compound BINOL-LA (1) having a rigid backbone ending up with two 5-membered cyclic disulfide moieties was designed. BINOL-LA capped Ag nanoparticles (1@Ag NPs) with a network structure were synthesized in a green way by sunlight or UV lamp irradiation. 1@Ag NPs exhibit a selective recognition towards ClO in aqueous solution with a switch-on fluorescence response and a visual color change, with detection limits of 0.

External Validation of the Diagnosis of TIA (DOT) Score for Identification of TIA in a Chinese Population.

Recently, the [diagnosis of transient ischemic attack (TIA), DOT] score has been recognized to be a new tool for non-specialists to diagnose TIA more accurately with the sensitivity and specificity being 89 and 76%, respectively. However, the DOT score has not yet been validated externally in patients with TIA in China. We retrospectively enrolled 500 consecutive patients with transient neurological symptoms, who were admitted to the Department of Neurology, Beijing Chaoyang Hospital and underwent magnetic resonance imaging (MRI) between Jan 2016 and Dec 2018.

Incidence and Predictors of Acute Ischemic Lesions on Brain Magnetic Resonance Imaging in Patients With a Clinical Diagnosis of Transient Ischemic Attack in China.

The associations between the clinical characteristics and diffusion-weighted imaging (DWI) positivity in patients with a clinical diagnosis of transient ischemic attack (TIA) are still poorly understood. The purpose of our study was to determine the incidence of TIA related acute infarction by DWI, and to determine the underlying predictors of DWI positivity in TIA patients. Between Jan 2017 and Dec 2018, we retrospectively enrolled 430 patients with a clinical diagnosis of TIA who underwent DWI.

Paraneoplastic neuromyelitis optica spectrum disorder associated with breast cancer.

Neuromyelitis optica spectrum disorder (NMOSD) is a group of inflammatory disease involving the central nervous system. Although most commonly an idiopathic autoimmune condition, NMOSD may also occur as a paraneoplastic syndrome in rare instances. Herein, we report a rare case of a 60-year-old woman with paraneoplastic NMOSD associated with breast cancer.