Substituting the Conventional Facebow With an Extraoral Scan Body System for Transferring the Maxillary Cast Into the Virtual Articulator: Manufacturing Procedures and Digital Clinical Protocol.

Clinical Considerations: Conventional facebow records are used to transfer the maxillary cast into the analog articulator. Different reference planes have been described, including the true horizontal or gravity reference plane. A conventional facebow (Kois Dentofacial Analyzer; Panadent) allows the recording of the gravity plane for transferring the maxillary cast into the analog semi-adjustable articulator.

Utilising terahertz pulsed imaging to analyse the anhydrous-to-hydrate transformation of excipients during immediate release film coating hydration.

Pharmaceutical tablets are routinely film-coated to improve appearance, reduce medication errors and enhance storage stability. Terahertz pulsed imaging (TPI) can be utilised to study the liquid penetration into the porous tablet matrix in real time. Using polymer-coated flat-faced tablets with anhydrous lactose or mannitol, we show that when the tablet matrix contains anhydrous material, the anhydrous form transforms to the solid-state hydrate form in the tablet core while the immediate release coating dissolves.

Roller compaction: Measuring ribbon porosity by terahertz spectroscopy and machine learning.

Roller compaction is a crucial unit operation in pharmaceutical manufacturing, with its ribbon porosity widely recognised as a critical quality attribute. Terahertz spectroscopy has emerged as a fast and non-destructive technique to measure porosity in pharmaceutical products. From a sensing perspective, the irregular shape and uneven surface of fragmented ribbon pieces can affect the accuracy and precision of the measurements, particularly for techniques that probe only a small sampling volume.

EVA implants for controlled drug delivery to the inner ear.

This study evaluated the potential of poly(ethylene vinyl acetate) (EVA) copolymers as matrix formers in miniaturised implants, allowing to achieve controlled drug delivery into the inner ear. Due to the blood-cochlea barrier, it is impossible to reliably deliver a drug to this tiny and highly sensitive organ in clinical practice. To overcome this bottleneck, different EVA implants were prepared by hot melt extrusion, altering the vinyl acetate content and implant diameter.

Influence of apical finish line location of tooth preparations on the scanning accuracy of intraoral scanners with various focal lengths and scanning technologies.

Statement Of Problem: Limited studies have reported the influence of finish line location on the accuracy of intraoral scanners (IOSs). Focal length is a hardware characteristic of IOSs. Whether there is a relationship between scanning accuracy of tooth preparations with the finish located at different apical positions and focal length and IOS technology or system remains uncertain.

Impact of immediate release film coating on the disintegration process of tablets.

Pharmaceutical tablets are often coated with a layer of polymeric material to protect the drug from environmental degradation, facilitate the packaging process, and enhance patient compliance. However, the detailed effects of such coating layers on drug release are not well understood. To investigate this, flat-faced pure microcrystalline cellulose tablets with a diameter of 13 mm and a thickness between 1.

Intraoral scanners as tracking devices: A dental protocol for assessing volumetric changes between intraoral scans.

Intraoral scanners (IOSs) are digital data acquisition technologies that ease the recording of virtual diagnostic casts. Some IOSs have a specific software tool to assess volumetric changes between 2 scans acquired on the patient at different times. The scans are superimposed and volumetric differences between both meshes are reported.

Is Ortho-Terphenyl a Rigid Glass Former?

Ortho-terphenyl (OTP) has long been used as a model system to study the glass transition due to its apparent simplicity and a widespread assumption that it is a rigid molecule. Here, we employ terahertz time-domain spectroscopy and low-frequency Raman spectroscopy to investigate the rigidity of OTP by direct observation of the low-frequency vibrational dynamics. These terahertz phonons involve complex large-amplitude atomic motions where intramolecular and intermolecular displacements are often mixed.

Calorimetric investigation on heat release during the disintegration process of pharmaceutical tablets.

The compendial USP〈701〉 disintegration test method offers a crucial pass/fail assessment for immediate release tablet disintegration. However, its single end-point approach provides limited insight into underlying mechanisms. This study introduces a novel calorimetric approach, aimed at providing comprehensive process profiles beyond binary outcomes.

An overview of the different digital facebow methods for transferring the maxillary cast into the virtual articulator.

Objectives: The purposes of this study were to classify the described digital facebow techniques for transferring the maxillary cast into the semi-adjustable virtual articulator based on the digital data acquisition technology used and to review the reported accuracy values of the different digital facebow methods described.

Overview: Digital data acquisition technologies, including digital photographs, facial scanners, cone beam computed tomography (CBCT) imaging, and jaw tracking systems, can be used to transfer the maxillary cast into the virtual articulator. The reported techniques are reviewed, as well as the reported accuracy values of the different digital facebow methods.

Use of an optical jaw tracking system to capture the envelope of function when designing interim and definitive prostheses: A dental technique.

Jaw tracking systems can record mandibular motion for incorporation into programs used for designing dental prostheses. However, the protocol for data acquisition and design using the recorded mandibular motion is unclear. The envelope of function recorded in a patient with acceptable occlusal function provides important functional information that can be integrated into the design of dental prostheses.

Accuracy of the maxillary cast transfer into the virtual semi-adjustable articulator by using analog and digital facebow record methods.

Statement Of Problem: Different digital methods have been described for transferring the maxillary cast into a virtual articulator; however, its accuracy remains uncertain.

Purpose: The purpose of this in vitro study was to compare the accuracy of the maxillary cast transfer into the virtual semi-adjustable articulator by using analog and digital methods.

Material And Methods: A maxillary typodont with 5 markers was positioned into a mannequin, which was digitized by using an industrial scanner (ATOS Q) and an extraoral scan of the typodont obtained (T710).

Accuracy comparison of the maxillary cast transfer into the virtual semi-adjustable articulator between an analog facebow record and a digital photography technique.

Statement Of Problem: Digital photographs can be used for transferring the maxillary cast into the virtual semi-adjustable articulator; however, its accuracy remains unknown.

Purpose: The purpose of the present study was to compare the accuracy of the maxillary cast transfer into the virtual semi-adjustable articulator by using an analog and a digital standardized photography technique.

Material And Methods: A maxillary cast was digitized (T710) and positioned into a dental mannequin.

Dynamical Transition in Dehydrated Proteins.

Terahertz time-domain spectroscopy and differential scanning calorimetry were used to study the role of the dynamics of biomolecules decoupled from solvent effects. Lyophilized sucrose exhibited steadily increasing absorption with temperature as anharmonic excitations commenced as the system emerged from a deep minimum of the potential energy landscape where harmonic vibrations dominate. The polypeptide bacitracin and two globular proteins, lysozyme and human serum albumin, showed a more complex temperature dependence.

Digital workflow to measure the mandibular range of motion using different jaw tracking technologies.

The analysis of the mandibular range of motion (ROM) includes the evaluation of maximum opening, deviation upon opening, and amplitude of the left and right excursive movements and protrusion. Conventionally, ROM assessment has been directly measured in the patient's mouth by using a ROM ruler. The development of jaw tracking systems, such as magnetometry and photometric devices, allows the digital assessment of the mandibular ROM.

Integrating the repeatable reference position and excursive movements of the mandible acquired using a jaw tracker into the design procedures of an occlusal device: A technique.

Jaw tracking systems can record mandibular movement such as the repeatable reference position and excursive movements of the mandible. A technique for integrating the recorded repeatable reference position of the mandible and excursive movements captured using an optical jaw tracking system into the design procedures of an occlusal device is described. The mandibular motion of the patient is directly used to design the occlusal device, replacing the virtual articulator.

Digital diagnostic occlusal equilibration combining an intraoral scanner, optical jaw tracking system, and dental design program: A dental technique.

Patients with aberrant occlusal patterns, including constricted mastication patterns or occlusal dysfunction, may require occlusal equilibration. Conventional diagnostic procedures involve diagnostic stone casts mounted in the articulator. During diagnostic procedures, occlusal equilibration methods are simulated on mounted stone casts to analyze the amount of dental structure that may need to be removed.

Implementing an optical jaw tracking system to locate centric occlusion: A dental technique.

Optical jaw tracking systems are designed to record the static maxillomandibular relationship and the mandibular motion of a patient, including excursive movements and mastication pattern. This digital data acquisition technology can be integrated into diagnostic and treatment planning procedures, as well as into designing dental prostheses. A step-by-step protocol to record a patient's digital data, including the repeatable reference position of the jaw or centric relation, by using an intraoral scanner, Kois deprogrammer, and optical jaw tracking system is described.

Drug release from PLGA microparticles can be slowed down by a surrounding hydrogel.

This study aimed to evaluate and better understand the potential impact that a layer of surrounding hydrogel (mimicking living tissue) can have on the drug release from PLGA microparticles. Ibuprofen-loaded microparticles were prepared with an emulsion solvent extraction/evaporation method. The drug loading was about 48%.

A sensitive AAV transduction inhibition assay assists evaluation of critical factors for detection and concordance of pre-existing antibodies.

Pre-existing antibodies to viral capsids may have a negative impact on the efficacy and safety of adeno-associated virus (AAV)-based gene therapies. Total antibody (TAb) and/or cell-based transduction inhibition (TI) assays have been used to exclude seropositive individuals in clinical studies. Published AAV seroprevalence and patient enrollment criteria regarding antibody status lack comparability between assay formats, hindering a direct cross-study comparison.

At-line porosity sensing for non-destructive disintegration testing in immediate release tablets.

Fully automated at-line terahertz time-domain spectroscopy in transmission mode is used to measure tablet porosity for thousands of immediate release tablets. The measurements are rapid and non-destructive. Both laboratory prepared tablets and commercial samples are studied.

Terahertz time-domain spectroscopy for the investigation of tablets prepared from roller compacted granules.

Roller compaction before tableting is a common unit operation to increase the processability of powders. Terahertz time-domain spectroscopy (THz-TDS) has recently been introduced as a potential process analytical technology (PAT) for measuring tablet porosity based on the refractive index of the tablet. Tablet porosity is a governing parameter for tablet disintegration and dissolution.

Maxillary occlusal device designed with an anterior platform for guiding the occlusal adjustments during the delivery appointment: A dental protocol.

Objective: To describe a technique for fabricating an additively manufactured maxillary occlusal device using a complete digital workflow.

Clinical Considerations: The maxillary occlusal device design may include an anterior platform to guide the positioning of the mandible in a reproducible position for facilitating the delivery procedure.

Conclusions: The described technique provides a more efficient and less time-consuming method for designing and manufacturing a printed occlusal device, when compared with conventional fabrication techniques.