Phytochemical analysis, antioxidant activity and modulatory effect of aqueous leaf extract of L on oxaliplatin-induced oxidative stress in isolated rat liver mitochondria.

This study evaluates the antioxidant effects of aqueous leaf extract of (ALEPL) and its potential to counteract oxaliplatin (OXA)-induced mitochondrial oxidative stress in rat livers, a common side effect of chemotherapy in cancer treatment. Bioactive compounds were identified using High-Performance Liquid Chromatography coupled with Tandem Mass Spectrometry (HPLC-MS and MS), with Fourier-Transform Infrared Spectroscopy (FTIR) and Atomic Absorption Spectrophotometry (AAS) for chemical and mineral analysis. ALEPL showed notable antioxidant activity, with IC50 values of 4.