Intercalation of manganese-mefenamic acid complex into double stranded of calf thymus DNA.

The interaction of the [Mn(mef)(phen)HO] complex in which mef is mefenamic acid drug and phen is 1,10 phenanthrolin ligand with calf thymus DNA (ct-DNA) was studied by using different spectroscopic methods, molecular docking and viscometery. The competitive fluorescence and UV-Vis absorption spectroscopy indicated that the complex interacted with ctDNA via intercalating binding mode with the binding constant of 1.16 × 10 Lmol.