Publications by authors named "Zeinab Aryanian"
Article Synopsis
- Spitz nevus is a rare benign tumor and this study examined its characteristics among Iranian patients from 2016-2021, focusing on demographics and histopathology.
- A total of 86 patients were studied, with a mean age of 15.6 years, and the most common locations were the upper extremities and face; most patients had disease durations of 1-2 years.
- The histopathological analysis showed different types of Spitz nevus, emphasizing the importance of further research in improving diagnostic methods.
Introduction: The skin is the largest organ system with many important clinical functions. Due to the increase in demand for cosmetic procedures and consequently the increase in complications from filler injections, this research aims to review the hospitalization cases involving filler complications.
Methodology: This study retrospectively and cross-sectionally reviews patient records hospitalized between the years 2016 to 2020, focusing on demographics (age, gender, residence), type of filler, type of complications, onset and duration of complications, duration of hospital stay, the person who administered the injection, and treatment outcomes.
Enhancing Wound Healing via Modulation of Autophagy-Induced Apoptosis: The Role of Nicotinamide Riboside and Resveratrol in Streptozotocin-Treated Diabetic Rat.
J Nutr Biochem
November 2024
Background: Impaired wound healing from diabetes mellitus (DM) causes lower limb amputations, posing clinical, social, and economic issues. Hypoxia and advanced glycation end products cause autophagy and apoptosis dysregulation, which delays wound healing. The study will test systemic and topical Nicotinamide Riboside (NR) and Resveratrol (RSV) for the capacity to modulate autophagy and apoptosis via the SIRT-1-FOXO1 pathway and improve diabetic wound healing.
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- Pemphigus is a rare autoimmune condition causing blisters due to autoantibodies targeting desmoglein, impacting patient management by revealing gender differences in disease characteristics through a study comparing male and female patients.
- The study analyzed data from 1,218 pemphigus patients, finding that males experienced disease onset at an older age with more severe symptoms in specific body areas, while females had more mucosal manifestations, particularly in the gums.
- Overall, out of 44 examined variables, significant gender differences were noted in 9, highlighting the need for tailored and gender-specific treatment strategies for pemphigus.
Article Synopsis
- Nonmelanoma skin cancer, particularly basal cell carcinoma (BCC), is the most common type of skin malignancy worldwide, highlighting the need for effective early detection strategies.
- This study analyzed clinical and pathological records of 229 BCC patients, revealing a high diagnostic accuracy, with 80.3% of cases confirmed as BCC upon pathological review and a significant number (42%) lacking prior clinical diagnoses.
- The findings stress the importance of better training for healthcare providers in recognizing BCC symptoms and suggest increased collaboration with dermatologists to enhance diagnostic skills and patient outcomes.
Procalcitonin (PCT) is a peptide precursor of calcitonin, considered as an infection marker in many settings. Recently, a few studies reported its rise in some inflammatory processes such as still's disease, anaphylactic shock and Kawasaki disease. To investigate the serum level of PCT in patients with pemphigus vulgaris (PV) and examine the relationship between serum level of PCT and the severity of disease.
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- Alopecia areata is a condition that causes hair loss and can be treated with a medicine called DPCP.
- Researchers studied 97 kids with this condition to see how well DPCP worked over time.
- After a year, about 9% of the kids had their hair fully regrow, and those who started with less severe symptoms did better with the treatment.
Background And Aim: Psoriasis is a prevalent chronic inflammatory skin condition, and the Mediterranean diet is often recommended for its health benefits, particularly its ability to mitigate chronic inflammation. This study sought to examine the extent to which psoriasis patients adhere to the Mediterranean diet and to explore its correlation with the severity of their condition.
Methods: Seventy-one psoriasis patients and 71 age- and sex-matched healthy controls were enrolled the study and filled a standard questionnaire of adherence to the Mediterranean diet.
Laser hair removal (LHR) has been established as a safe and efficient method for eliminating unwanted hair. This study aimed to investigate the frequency of LHR complications and assess the contributing factors. During one year, 16,900 patients undergoing LHR therapy were evaluated for complications.
View Article and Find Full Text PDFPemphigus vulgaris (PV) is a rare, yet serious autoimmune disorder primarily affecting the skin and mucous membranes. While the dermatological and mucosal aspects of PV are well-documented, the potential for systemic involvement, particularly cardiac complications, remains under-explored. This study aimed to investigate the serum cardiac troponin I (cTnI) level in patients with PV versus healthy controls.
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- The study focuses on facial granulomatous dermatoses, acknowledging the difficulty in diagnosing these skin conditions due to overlapping histologic features from different causes.
- Researchers analyzed 150 patient records from 2016 to 2021, finding rosacea to be the most common diagnosis, followed by sarcoidosis and leishmaniasis, with a notable gender bias in clinical diagnosis.
- The conclusion emphasizes the importance of a multidisciplinary approach in understanding and managing the complex nature of facial granulomatous dermatoses, as both age and gender significantly influence diagnosis.
Background: Alopecia areata is a chronic and relapsing condition that affects individuals of all age groups. Dermoscopy is a popular and non-invasive method for diagnosing alopecia areata. This study aimed to analyze dermoscopic findings and their relationship with age, gender, appearance, and clinical signs in children and adults.
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- Diabetes-related skin ulcers pose serious health risks, often leading to amputation, prompting research into effective treatments through Nicotinamide Riboside (NR) and Resveratrol (RV), known for their anti-inflammatory and NAD-boosting properties.* ! -
- In a study involving 54 diabetic rats, both NR and RV treatments were shown to significantly improve wound healing, reduce inflammation, and promote cellular recovery better than either treatment alone.* ! -
- The findings suggest that combining NR and RV could be an effective strategy for treating diabetic wounds by regulating the unfolded protein response (UPR) and reducing pyroptosis, offering a new approach to clinical care.* !
Key Clinical Message: Mycosis fungoides is a diagnostic challenge. Herein, we report a case with marked lichenoid features in pathology assessments. After several biopsies and clinicopathologic correlation, the diagnosis of lichenoid mycosis fungoides was made.
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- - The study investigates advanced glycation end products (AGE) and their measurement through skin autofluorescence (SAF) in diabetes mellitus (DM) versus nondiabetic individuals, highlighting AGEs' role in protein dysfunction related to aging.
- - Researchers conducted a comprehensive literature search and found that DM patients had significantly higher SAF levels and HbA1c, indicating greater AGE accumulation compared to nondiabetics, with notable differences in age, gender, and BMI factors.
- - Despite these findings, the study concludes that SAF may not be a reliable marker for AGEs in diabetes patients at this stage, although it suggests potential future applications in assessing metabolic syndrome.
Article Synopsis
- Increased awareness of cutaneous leishmaniasis (CL) is essential in endemic areas, as it can resemble other skin conditions and may lead to serious complications.
- Two cases of chronic leishmaniasis that were misdiagnosed for years highlight the importance of early identification and treatment.
- Clinicians should strongly suspect leishmaniasis in patients with infiltrated lesions and start treatment without waiting for definitive lab tests to prevent disfigurement and secondary cancers.
Key Clinical Message: The immunosuppressant agents should be considered earlier in the course of treatment with rituximab, possibly after the unfavorable response at first cycle of treatment, especially in male patients and those with high BMI.
Abstract: Rituximab (RTX) has recently been proposed as an alternative first-line therapy for pemphigus patients. However, there are some rare reports of worsening of pemphigus following RTX therapy in the literature.
Cutaneous manifestations in patients with end-stage renal disease on hemodialysis.
Caspian J Intern Med
January 2023
Article Synopsis
- End-stage renal disease (ESRD) can lead to various skin issues that impact patients' quality of life, making early recognition and treatment important.
- A study involving 150 hemodialysis patients revealed common skin problems, including dry skin (84.7%), pallor (82.7%), and itching (67.3%), along with skin infections in 36% of cases.
- The research concluded that skin conditions are prevalent in ESRD patients and timely management may enhance their overall quality of life.