Treatment of localized non-segmental vitiligo with intradermal 5-flurouracil injection combined with narrow-band ultraviolet B: a preliminary study.

Background: Several treatment modalities had been used for the treatment of vitiligo but the optimal treatment has not yet been identified.

Aim: To evaluate the efficacy and safety of intradermal injection of 5-flurouracil (5-FU) combined with narrow-band ultraviolet B (NB-UVB) as a treatment option for vitiligo.

Patients And Methods: The study included 60 vitiligo patients with overall symmetrical lesions affecting less than 30% of body surface area.

Nerve growth factor, neuropeptides and cutaneous nerves in atopic dermatitis.

Introduction: Neurogenic components, as neurotrophic factors and neuropeptides, are probably involved in the pathogenesis of atopic dermatitis (AD) with the neuroimmunocutaneous system as they modify the functions of immunoactive cells in the skin. Nerve growth factor (NGF) is the best-characterized member of the neurotrophin family. Both NGF and neuropeptides (NPs) may be associated with the disease pathogenesis.