Publications by authors named "Zeila Casiraghi"
Article Synopsis
- The LRRK2 protein has important functional areas at both ends that help it interact with other proteins, and mutations in the LRRK2 gene are associated with Parkinson's disease.
- A new variant, E193K, in the N-terminal region of LRRK2 was examined for its effects on vesicle trafficking using advanced microscopy techniques.
- The study found that the E193K variant disrupts LRRK2's normal binding to synaptic vesicles and enhances vesicle fusion, indicating that mutations in LRRK2 can significantly affect its role in cellular processes related to Parkinson's disease.
