Numerical investigation of mixed physical barriers for saltwater removal in coastal heterogeneous aquifers.

Saltwater intrusion is a prevalent global environmental issue that detrimentally impacts coastal groundwater aquifers. This problem is exacerbated by climate change and increased groundwater abstraction. Employing physical barriers proves effective in mitigating saline water intrusion.

Water quality assessment of Lake Burullus, Egypt, utilizing statistical and GIS modeling as environmental hydrology applications.

GIS is a very powerful tool for analyzing huge amount of data and connecting them with the geography; moreover, recently, there is great advancement in the field. The main objective of this study is to assess the water quality (WQ) and trophic status (TS) conditions of Lake Burullus, Egypt, using statistical modeling (PCA/FA and CA), WQ index (L-WQI), and trophic status index (Carlson TSI and TRIX) approaches, in addition to using GIS tools for building models able to automatically calculate the various indices and producing color coded maps for the lake. The results indicated that PCA/FA grouped the twenty-four WQ parameters into nine principal components explaining 72.

Cryptogenic Organizing Pneumonia Secondary to Mycoplasma pneumoniae Infection: A Case Report.

Cryptogenic organizing pneumonia (COP), previously known as bronchiolitis obliterans organizing pneumonia (BOOP), is a serious lung disease that can cause significant and long-term damage to the distal respiratory tract. Here we describe an unusual case in which an adult patient with recent mycoplasma pneumonia developed worsening lower airway disease despite initiation of multiple antibiotic therapies, illustrating the immunological effects related to infections. It is critical that clinicians learn how to recognize early signs of COP in order to tailor appropriate therapy, reduce morbidity, and improve quality of life.

Overlap of Granulomatosis With Polyangiitis and IgA Nephropathy.

Acute glomerulonephritis is a constellation of renal disorders which are precipitated by an immunologic mechanism triggering inflammation and proliferation of glomerular tissue resulting in damage to the basement membrane, mesangium, or capillary endothelium. Two of the most well-known manifestations of glomerulonephritis are granulomatosis with polyangiitis (GPA) and IgA nephropathy (IgAN). To our knowledge, these diseases are often found separately and are rarely diagnosed in the same patient.

Water quality modeling and management for Rosetta Branch, the Nile River, Egypt.

Rosetta Branch (RB) is the Nile western branch, which is considered the main freshwater resource for the western governorates of the Nile Delta, in addition to El-Beheira governorate, Egypt. This work aims to investigate the effectiveness of applying six feasible water quality management scenarios for the RB at Kafr Elzayat (KZ) City, where two major pollution sources (industrial companies and the Tala Drain) are discharging their effluents to the branch. A hydro-ecological model for the branch was developed based on MIKE 11 modeling system (3 modules).

Advanced breast conservation and partial breast reconstruction - a review of current available options for oncoplastic breast surgery.

Breast cancer is the most common cancer affecting one in three women with new cancer diagnosis in England. Breast-conserving surgery is the primary surgical option in a vast majority of these patients. Use of oncoplastic techniques in breast conservation surgery has significantly improved the aesthetic outcomes without compromising the oncological safety of cancer resections.

Diabetic Ketoacidosis Secondary to New Onset Type 1 Diabetes Mellitus Related to Pembrolizumab Therapy.

Pembrolizumab is an immunoglobulin G4 (IgG4) monoclonal antibody used in the treatment of various types of cancers. Despite its efficacy, pembrolizumab does not specifically target cancer cells which often leads to common side effects seen in immunotherapies such as diarrhea, rash, fatigue, nausea, decreased appetite, pruritus, and endocrinopathies. Type 1 diabetes mellitus (T1DM) has been reported in 0.

Pasteurella multocida Bacteremia in an Immunocompromised Patient After Multiple Cat Scratches.

(P. multocida) is a zoonotic organism found in the normal flora of domestic and wild animals. In this case report, we present a 70-year-old Caucasian male who presented with fever, chills, and greenish sputum which began hours prior to presentation.

Adverse Side Effects: Empagliflozin-Related Acute Pancreatitis Case Report.

Acute pancreatitis is an acute inflammatory process of the pancreas that is associated with multiple etiologies. The two most common causes are gallstones and acute alcohol intoxication. However, medications are often overlooked when determining the cause.

A Case Report of Babesiosis Seen Outside of its Endemic Area and Incubation Period.

is a parasitic alveolate that is usually transmitted by tick, which also transmits Lyme disease. Babesiosis is endemic in the Northeast and Upper Midwestern regions of the United States. This case report illustrates a 29-year-old Hispanic male who presented to a Florida hospital emergency department with complaints of fever, generalized weakness, and flu-like symptoms over a duration of four days.

Water quality monitoring of Lake Burullus (Egypt) using Landsat satellite imageries.

Lake Burullus is one of the most important coastal lakes in Egypt, as it participates with a considerable amount of fish yield in Egypt. Despite its importance, it is considered as a vulnerable lake, since it is subjected to significant environmental changes caused by various anthropogenic activities. Severe deterioration of its water quality status, as well as a decrease in its water area, has been noticed throughout the last four decades.

Assessment of climate change impacts on water quality parameters of Lake Burullus, Egypt.

Egyptian Mediterranean coast hosts five shallow lagoons which play a vital role in the national economy. Lake Burullus is the second largest one that is located in the Nile Delta and is connected to the Mediterranean by a narrow outlet. This lagoon faces various anthropogenic-induced implications that threat its ecosystem and biodiversity.

Increased circulating resistin levels in early-onset breast cancer patients of normal body mass index correlate with lymph node negative involvement and longer disease free survival: a multi-center POSH cohort serum proteomics study.

Background: Early-onset breast cancer (EOBC) affects about one in 300 women aged 40 years or younger and is associated with worse outcomes than later onset breast cancer. This study explored novel serum proteins as surrogate markers of prognosis in patients with EOBC.

Methods: Serum samples from EOBC patients (stages 1-3) were analysed using agnostic high-precision quantitative proteomics.

Drought analysis in the Eastern Nile basin using the standardized precipitation index.

Drought is considered by many researchers to be the most complex but least understood of all natural hazards, affecting more people than any other hazard. Drought affects many aspects of community and environment, and any future increases in the water demand will be most critical in periods of severe drought. Geospatial analysis of the historical drought events and their causes can be used to mitigate drought impacts and to develop preparedness plans.

Change detection for Lake Burullus, Egypt using remote sensing and GIS approaches.

Lake Burullus is the second largest natural coastal lake in Egypt. It has an economic importance for fish yield. However, several anthropogenic activities such as industrial, agriculture, and reclamation activities lead to a deterioration of its water quality and a decrease of the water body area of the lake.

The impact of tamoxifen brand switch on side effects and patient compliance in hormone receptor positive breast cancer patients.

Background: In 2006 Nolvadex was discontinued and replaced by a variety of alternative generic tamoxifen brands for the adjuvant treatment of breast cancer. Anecdotally, patients are switching brands and taking alternative medications to reduce treatment related symptoms. Nevertheless, more severe side effects may equate to better relapse prevention.

Annexin A3 is a mammary marker and a potential neoplastic breast cell therapeutic target.

Breast cancers are the most common cancer-affecting women; critically the identification of novel biomarkers for improving early detection, stratification and differentiation from benign tumours is important for the reduction of morbidity and mortality.To identify and functionally characterise potential biomarkers, we used mass spectrometry (MS) to analyse serum samples representing control, benign breast disease (BBD) and invasive breast cancer (IDC) patients. Complementary and multidimensional proteomic approaches were used to identify and validate novel serum markers.

Clinical proteomics and breast cancer.

Background: Breast cancer is a heterogeneous disease. Yet, many molecular players and mechanisms behind the complexity of its clinical behaviour remain unknown, and advances in biomedical research are expected to unravel novel molecular discoveries in breast and other cancers. Clinical proteomics is currently experiencing rapid advances in technology that promise new means to improve breast cancer early diagnosis, stratification, and treatment response.

Complexities of abdominoperineal surgery: synchronous resection of an ano-rectal adenocarcinoma and pelvic schwannoma.

Abdominoperineal resection (APR) is indicated for low rectal/ano-rectal cancers. It necessitates fastidious pelvic dissection posing certain operative difficulties. We present the surgical challenges in a unique case of a patient presenting with a low rectal adenocarcinoma and a synchronous pelvic schwannomas, both requiring resection.

A case of idiopathic tracheal stenosis.

Acquired tracheal stenosis is a condition that often results from trauma, neoplasm, infection, vasculitis, inflammatory or infiltrative processes. Idiopathic tracheal stenosis is a rare entity and represents a diagnosis of exclusion. We report a case of severe localized extrathoracic tracheal stenosis in a 35 year old female who was initially suspected to have asthma as the cause of several months of chronic dyspnea.

Proteomic profiling to identify prognostic biomarkers in heart failure.

Background: The ability to predict mode, as well as risk, of death in left ventricular systolic dysfunction (LVSD) is important, as the clinical and cost-effectiveness of implantable cardioverter defibrillators (ICD) therapy depends on its use in appropriately selected patient populations. The value of a proteomic approach in identifying prognostic biomarkers in LVSD is unknown. The aims of this pilot study were to use proteomic techniques to identify serum biomarkers associated with LVSD and to prospectively explore their association with prognosis.

Discovery of serum protein biomarkers for prostate cancer progression by proteomic analysis.

Background: The incidence of prostate cancer (PCa) has increased in recent years due to the aging of the population and increased testing; however, mortality rates have remained largely unchanged. Studies have shown deficiencies in predicting patient outcome for both of the major PCa diagnostic tools, namely prostate specific antigen (PSA) and transrectal ultrasound-guided biopsy. Therefore, serum biomarkers are needed that accurately predict prognosis of PCa (indolent vs.

Proteomics in prostate cancer biomarker discovery.

Despite advances in molecular medicine, genomics, proteomics and translational research, prostate cancer remains the second most common cause of cancer-related mortality for men in the Western world. Clearly, early detection, targeted treatment and post-treatment monitoring are vital tools to combat this disease. Tumor markers can be useful for diagnosis and early detection of cancer, assessment of prognosis, prediction of therapeutic effect and treatment monitoring.

Proteomic analysis of archival breast cancer serum.

Large cohorts of archival samples are stored in tissue banks worldwide yet their contribution to biomarker discovery is limited. Proteomic profiling technologies have potential for early screening and diagnosis of cancer, and data from such samples can be the answer for many clinical questions. Here we introduce the notion of archival samples proteomics.

Aggressive multi-visceral pancreatic resections for locally advanced neuroendocrine tumours. Is it worth it?

Context: Traditional surgical principles state that pancreatic resection should not be contemplated when malignancies arise in the pancreas and involve other organs. While this is logic for ductal adenocarcinoma and other tumours with aggressive biological behavior; for even large neuroendocrine tumours, aggressive multivisceral resection may achieve useful palliation and excellent survival.

Design: Case records were retrospectively analyzed.