Impact of camel milk lactoferrin peptides against breast cancer cells: and study.

Background And Aims: Breast cancer remains a significant global health concern, necessitating the exploration of novel therapeutic strategies. Despite advancements in cancer therapeutics, effective treatments with minimal side effects remain elusive. Natural sources, such as camel milk, harbor bioactive compounds such as lactoferrin peptides, which hold promise as anticancer agents.

Azolla pinnata as a phytoremediator: improves germination, growth and yield of maize irrigated with Ni-polluted water.

The removal of pollutants from the environment has become a global demand. The current study aimed to relieve the Ni toxicity effect on the germination, growth, and grain yield of maize by using Azolla pinnata as a phytoremediator. Azolla-treated and untreated nickel solutions [0 (control), 24, 70, 140 and 190 ppm] were applied for germination and pot experiments.

Bioassessment of Cd and Pb at Multiple Growth Stages of Wheat Grown in Texturally Different Soils Using Diffusive Gradients in Thin Films and Traditional Extractants: A Comparative Study.

The bioavailability of heavy metals in soil is a crucial factor in determining their potential uptake by plants and their subsequent entry into the food chain. Various methods, including traditional chemical extractants and the diffusive gradients in thin films (DGT) technique, are employed to assess this bioavailability. The bioavailability of heavy metals, particularly cadmium (Cd) and lead (Pb), is also influenced by soil texture and their concentrations in the soil solution.

Current genetic models for studying congenital heart diseases: Advantages and disadvantages.

Congenital heart disease (CHD) encompasses a diverse range of structural and functional anomalies that affect the heart and the major blood vessels. Epidemiological studies have documented a global increase in CHD prevalence, which can be attributed to advancements in diagnostic technologies. Extensive research has identified a plethora of CHD-related genes, providing insights into the biochemical pathways and molecular mechanisms underlying this pathological state.

Coumarin-amino acid hybrids as promising anticancer agents: design, synthesis, docking studies and CK2 inhibition.

A series of mono-peptide, di-peptide and tri-peptide derivatives linked to a coumarin scaffold (5a-c, 7a-c, and 9a-c) were synthesized the azide-coupling method from corresponding hydrazides 4, 6, and 8. These compounds were tested for anticancer activity against HepG-2, PC-3, and Hct-116 cell lines. Compounds, 7c, and 5b showed significant cytotoxicity, outperforming doxorubicin, with IC values of 34.

Theoretical electronic structure with spin-orbit coupling effect of the molecules SrAt and BaAt for laser cooling studies.

Ab initio CASSCF/MRCI + Q calculations have been used to investigate the electronic structure and transition properties of the alkaline earth astatine molecules SrAt and BaAt. The adiabatic potential energy curves have been computed and plotted for the low-lying electronic states in the representations Λ and Ω (with and without spin-orbit coupling effect). The spectroscopic and vibrational constants have been deduced for the corresponding bound states.

Prediction of anticancer peptides derived from the true lectins of and their synergetic effect with mitotane.

Cancer continues to be a significant source of both illness and death on a global scale, traditional medicinal plants continue to serve as a fundamental resource of natural bioactive compounds as an alternative source of remedies. Although there have been numerous studies on the therapeutic role of , the study of the role of peptides has not been thoroughly investigated. This study aimed to investigate the anticancer activity of lectin peptides from using and analysis.

Multi-targeted therapeutic potential of stigmasterol from the Euphorbia ammak plant in treating lung and breast cancer.

Cancer is the most prevalent disease globally, which presents a significant challenge to the healthcare industry, with breast and lung cancer being predominant malignancies. This study used RNA-seq data from the TCGA database to identify potential biomarkers for lung and breast cancer. Tumor Necrosis Factor (TNFAIP8) and Sulfite Oxidase (SUOX) showed significant expression variation and were selected for further study using structure-based drug discovery (SBDD).

Intrinsic factors behind long COVID: IV. Hypothetical roles of the SARS-CoV-2 nucleocapsid protein and its liquid-liquid phase separation.

When the SARS-CoV-2 virus infects humans, it leads to a condition called COVID-19 that has a wide spectrum of clinical manifestations, from no symptoms to acute respiratory distress syndrome. The virus initiates damage by attaching to the ACE-2 protein on the surface of endothelial cells that line the blood vessels and using these cells as hosts for replication. Reactive oxygen species levels are increased during viral replication, which leads to oxidative stress.

Alleviation of carbendazim toxicity effect by oil and L oil on testes of male rats: Physiological, histological and study.

Carbendazim (CBZ) is a widely used fungicide that is used to control the unwanted growth of fungi on fruits and vegetables. Sixty male rats were divided into six groups, each having ten. Group one served as control, animals belonging to group two were exposed to CBZ in the measure of 200 mg/kg body weight (BW).

Overview of the SARS-CoV-2 nucleocapsid protein.

Since the emergence of SARS-CoV in 2003, researchers worldwide have been toiling away at deciphering this virus's biological intricacies. In line with other known coronaviruses, the nucleocapsid (N) protein is an important structural component of SARS-CoV. As a result, much emphasis has been placed on characterizing this protein.

Effect of iron nanoparticles and conventional sources of Fe on growth, physiology and nutrient accumulation in wheat plants grown on normal and salt-affected soils.

Salt stress is becoming a serious problem for the global environment and agricultural sector. Different sources of iron (Fe) can provide an eco-friendly solution to remediate salt-affected soils. The Fe nanoparticles (FeNPs) and conventional sources of Fe (iron-ethylene diamine tetra acetic acid; Fe-EDTA; and iron sulfate; FeSO) were used to evaluate their effects on wheat crop grown in normal and salt-affected soils.

Responses of two strawberry cultivars to NaCl-induced salt stress under the influence of ZnO nanoparticles.

Salinity stress is one of the most serious impacts of climate changes on agriculture production, especially in salt sensitive crop plants, like strawberry. Currently, the utilization of nanomolecules in agriculture is thought to be a useful strategy to compact abiotic and biotic stresses. This study aimed to investigate the effect of zinc oxide nanoparticles (ZnO-NPs) on the growth, ions uptake, biochemical and anatomical responses of two strawberry cvs (Camarosa and Sweet Charlie) under NaCl-induced salt stress.

Molecular insights into novel environmental strains of harboring different antimicrobial-resistance genes.

Introduction: The emergence of bacterial pathogens in environmental hosts represents a major risk to public health. This study aimed at characterizing seven novel environmental strains of using a genomic approach which was misidentified by phenotypic methods in a previous batch of 27 species thought to be .

Methods: Whole-genome sequencing was performed using the Illumina platform, and the generated raw reads were assembled.

Laser cooling and electronic structure of Be halide anions BeX (X = Cl, Br, F, and I).

The adiabatic potential energy curves of the low lying electronic states of the Be halide anions BeX (Cl, Br, F, and I) have been investigated in the representation Λ by using the complete active space self-consistent field with a multireference configuration interaction method. The spectroscopic parameters T, R, ω, and B and the static and transition dipole moment μ were studied, and a rovibrational study of the investigated electronic states was performed. New electronic states were investigated here for the first time.

Laser Cooling with an Intermediate State and Electronic Structure Studies of the Molecules CaCs and CaNa.

The ground and excited electronic states of the diatomic molecules CaCs and CaNa have been investigated by implementing the ab initio CASSCF/(MRCI + Q) calculation. The potential energy curves of the doublet and quartet electronic low energy states in the representation Λ have been determined for the two considered molecules, in addition to the spectroscopic constants , ω, , , and the values of the dipole moment μ and the dissociation energy . The determination of vibrational constants , , , and the turning points and up to the vibrational level = 100 was possible with the use of the canonical functions schemes.

Arabica coffee and olive oils mitigate malathion-induced nephrotoxicity in rat, immunohistochemical and biochemical evaluation.

Malathion (MAL) is an organophosphate insecticide that disrupts the body's antioxidant system; it is one of the earliest organophosphate insecticides extensively used as dust, emulsion, and vapor control a wide variety of insect pests under different conditions. This experimentation aims to evaluate the influence of Arabica coffee oil and olive oil on MAL-induced nephrotoxicity in male rat. 6 sets bearing the same number of animals were applied to this experiment.

evaluation of some high yield potato ( L.) cultivars under imposition of salinity at the cellular and organ levels.

Salinity and drought stress, which combines a lack of water and sodium toxicity, are more of the problems faced by plants and agricultural crops in newly reclaimed lands. Therefore, the direction of our research is to produce salinity-tolerant plants to increase the productivity of crops under conditions of salt stress. Potato callus was studied using different concentrations of NaCl (0.

Predominance of Antioxidants in Some Edible Plant Oils in Ameliorating Oxidative Stress and Testicular Toxicity Induced by Malathion.

Malathion (MAL) is an insecticide that has been linked to reproductive system damage in both humans and animals. In the present investigation, the antitoxic effects of coffee and olive oils on MAL-induced testicular dysfunctions were evaluated. MAL-intoxicated rats were supplemented with coffee and olive oils (400 mg/kg) for 7 weeks.

A theoretical electronic structure with a feasibility study of laser cooling of LaNa molecules with a spin orbit effect.

The electronic structure with the spin orbit effect of the molecule LaNa has been studied in the present work using the Multi-Reference Configuration Interaction MRCI calculations including Davidson correction (+). Adiabatic potential energy curves (PECs) have been investigated for the lowest low-lying spin free states in the Λ representation and spin orbit states of Ω = 0, 1, 2, 3, and 4 along with their spectroscopic constants , , , and , the dissociation energy , the dipole moment , and the ionic character of the LaNa molecule at the equilibrium bond length. The permanent dipole moment curves (PDMCs) for the investigated states are calculated in addition to the electronic transition dipole moments between the lowest electronic states where the Franck-Condon factor (FCF) has been calculated for the XΣ-1Π and for many spin orbit transitions.

Alleviation of Malathion Toxicity Effect by L. Oil and L. Oil on Lipid Profile: Physiological and In Silico Study.

The community health plans commonly use malathion (MAL), an organophosphate pesticide (OP), to eliminate pathogenic insects. The objective of the present research is to evaluate the consequences of L. oil and L.

Electronic Structures and Transition Properties of BeSe and BeTe Molecules.

The electronic structure of BeSe and BeTe molecules has been investigated using the CASSCF/(MRCI + Q) method at the spin-free and spin-orbit level. The potential energy curves, the permanent dipole moment, the spectroscopic constants , , ω, and , and the dissociation energy are determined in addition to the vertical transition energy T. The molecules' percentages of ionic character are deduced, and the trends of the spectroscopic constants of the two molecules are compared and justified.

Synthesis of Eco-Friendly Biopolymer, Alginate-Chitosan Composite to Adsorb the Heavy Metals, Cd(II) and Pb(II) from Contaminated Effluents.

Efficient removal of Cd(II) and Pb(II) from contaminated water is considered a fundamental point of view. Synthetic hydrogel biopolymers based on chitosan and alginate (cost-effective and eco-friendly) were successfully designed and characterized by highly efficient removal contaminants. The sorbents are characterized by FTIR, SEM-EDX, TGA, XPS analyses and textural properties which are qualified by N adsorption.

Antihyperglycemic, Antioxidant and Antiapoptotic Effect of Rhizophora Mucronata and Avicennia Marina in Streptozotocin-induced Diabetic Rats.

Introduction: Diabetes mellitus is a common disease worldwide. It is considered as the third leading cause of death, in the developed countries followed by heart diseases and cancer.

Aim: The aim of this study was to assess the effectiveness of the aqueous fraction of R.

Potential Nutraceutical Benefits of In Vivo Grown Saffron (Crocus sativus L.) As Analgesic, Anti-inflammatory, Anticoagulant, and Antidepressant in Mice.

Crocus sativus, a medicinally important herbaceous plant, has been traditionally used to cure coughs, colds, insomnia, cramps, asthma, and pain. Moreover, the therapeutic applications of saffron include its immunomodulatory and anticancer properties. The current experimental analysis was performed to explore the potential nutraceutical efficacy of corm, leaf, petal, and stigma of saffron ethanolic extracts as analgesic, anti-inflammatory, anticoagulant, and antidepressant using hot plate, carrageenan-induced paw edema, capillary tube and forced swim test, respectively in mice.