Theoretical Investigation and Parametric Sensitivity Analysis of Polypropylene-Polyester Fiber-Reinforced Recycled Brick Aggregate Concrete Pavement Humidity Warping Stress During the Service Life.

Pavement humidity warping is a critical factor limiting the application of PPRBAC on low-volume roads. A nonlinear wet-warping stress formula for PPRBAC slabs has been derived based on previous experimental results, and the finite element method was employed to develop a single-board model in order to verify the accuracy of the analytical solution. Subsequently, the finite difference method, in conjunction with the finite element method, was employed to investigate the calculation methodology for wet-warping stress in PPRBAC slabs during service.

Outcomes and risk factors associated with in-hospital mortality in patients undergoing coronary artery bypass grafting with low ejection fraction.

Objective: To investigate the short-term prognosis and risk factors associated with in-hospital mortality in patients undergoing coronary artery bypass grafting (CABG) with low ejection fraction.

Methods: Clinical data were collected from 765 patients who underwent CABG with an ejection fraction of less than 40% between 2019 and 2023 at Anhui Chest Hospital and Beijing Anzhen Hospital, Capital Medical University. The patients were categorized into a in-hospital mortality group ( = 38) and a in-hospital survival group ( = 727), based on whether they died within 30 days post-operation.

Digital Profiling of Immune Biomarkers in Breast Cancer: Relation to Anthracycline Benefit.

Assessment of the tumor-immune microenvironment can be used as a prognostic tool for improved survival and as a predictive biomarker for treatment benefit, particularly from immune-modulating treatments including cytotoxic chemotherapy. Using digital spatial profiling (DSP), we studied the tumor-immune microenvironment of 522 breast cancer cases by quantifying 35 immune biomarkers on tissue microarrays from the MA.5 phase III clinical trial.

Study on Mechanical Properties and Carbon Emission Analysis of Polypropylene Fiber-Reinforced Brick Aggregate Concrete.

Given the current construction waste accumulation problem, to utilize the resource of red brick solid waste, construction waste red brick was used as a concrete coarse aggregate combined with polypropylene fiber to prepare PPF (polypropylene fiber)-reinforced recycled brick aggregate concrete. Through a cube compression test, axial compression test, and four-point bending test of 15 groups of specimens, the influences of the aggregate replacement rate of recycled brick and the PPF volume on the mechanical properties of recycled brick aggregate concrete reinforced by PPF were studied, and a strength parameter calculation formula was constructed and modified based on the above. Finally, combined with a life cycle assessment (LCA), the carbon emissions of raw materials were analyzed and evaluated.

Flexible pressure sensor with metallic reinforcement and graphene nanowalls for wearable electronics device.

In recent years, flexible pressure sensors have been seen widespread adoption in various fields such as electronic skin, smart wearables, and human-computer interaction systems. Owing to the electrical conductivity and adaptability to flexible substrates, vertical graphene nanowalls (VGNs) have recently been recognized as promising materials for pressure-sensing applications. Our study presented the synthesis of high-quality VGNs via plasma enhanced chemical vapor deposition and the incorporation of a metal layer by electron beam evaporation, forming a stacked structure of VGNs/Metal/VGNs.

A Bacterial Platform for Studying Ubiquitination Cascades Anchored by SCF-Type E3 Ubiquitin Ligases.

Ubiquitination is one of the most important post-translational modifications in eukaryotes. The ubiquitination cascade includes ubiquitin-activating enzymes (E1), ubiquitin-conjugating enzymes (E2), and ubiquitin ligases (E3). The E3 ligases, responsible for substrate recognition, are the most abundant and varied proteins in the cascade and the most studied.

Superoxide dismutase positively regulates Cu/Zn toxicity tolerance in Sorghum bicolor by interacting with Cu chaperone for superoxide dismutase.

Heavy metal stress threatens plant growth and productivity. In this study, we investigated the effects of CuSO and ZnSO toxicity on sorghum seedlings, focusing on their impact on biomass, germination rates, growth parameters, antioxidant enzyme activities, gene expression profiles, and stress resistance mechanisms. As a result, eight sorghum superoxide dismutase (SOD) genes were identified, and their evolutionary relationships with cis-acting regulatory elements and their expressional patterns were evaluated.

Deep Eutectic Solvent and Molten Salt-Assisted Construction of Wheat Straw-Derived N/O Co-Doped Porous Carbon for Flexible Zinc-Air Batteries.

As a common biomass resource, wheat straw is gradually being derived as carbon materials for oxygen reduction reaction (ORR) in zinc-air batteries (ZABs). Herein, the wheat straw-derived carbon was prepared by ball milling and pyrolysis using deep eutectic solvent (DES) as the medium, which avoided the cumbersome procedures. The hydrogen bond of DES was utilized to reconstructed into a hydrogen bond network structure between DES and lignin/cellulose/hemicellulose of wheat straw.

Synergistic Elimination of Chlorophenols Using a Single-Atom Nickel with Single-Walled Carbon Nanotubes: The Roles of Adsorption, Hydrodechlorination, and the Electro-Fenton Process.

Electrocatalytic degradation enables the efficient treatment of chlorinated pollutants (COPs); however, its application has been significantly hindered by the large amounts of unsafe intermediate products. In this study, we present a single-atom nickel with single-walled carbon nanotubes (SWCNTs) as an electrochemical reactor for the complete elimination of chlorophenols. Distinct products and reductive mechanisms were observed for Ni-N-C compared to Cu-N-C.

Ru@MoCO MXene single-cluster catalyst for highly efficient N-to-NH conversion.

Single-cluster catalysts (SCCs) representing structurally well-defined metal clusters anchored on support tend to exhibit tunable catalytic performance for complex redox reactions in heterogeneous catalysis. Here we report a theoretical study on an SCC of Ru@MoCO MXene for N-to-NH thermal conversion. Our results show that Ru@MoCO can effectively activate N and promotes its conversion to NH through an association mechanism, in which the rate-determining step of NH* + H* → NH* has a low energy barrier of 1.

Self-assembly-integrated tumor targeting and electron transfer programming towards boosting tumor type I photodynamic therapy.

Type I photodynamic therapy (PDT) is attracting increasing interest as an effective solution to the poor prognosis of patients with hypoxic tumors. The development of functional type I photosensitizers is limited by a lack of feasible strategies to systematically modulate electron transfer (ET) in photosensitization. Herein, we present an easily accessible approach for the preparation of nanophotosensitizers with self-assembly-integrated tumor-targeting and ET programming towards boosting tumor type I PDT.

A Cascade xDAWN EEGNet Structure for Unified Visual-Evoked Related Potential Detection.

Visual-based brain-computer interface (BCI) enables people to communicate with others by spelling words from the brain and helps professionals recognize targets in large numbers of images. P300 signals evoked by different types of stimuli, such as words or images, may vary significantly in terms of both amplitude and latency. A unified approach is required to detect variable P300 signals, which facilitates BCI applications, as well as deepens the understanding of the P300 generation mechanism.

Gut microbiota's influence on erysipelas: evidence from a two-sample Mendelian randomization analysis.

Background: Previous studies have suggested a link between gut microbiota and skin diseases, including erysipelas, an inflammatory skin condition. Despite this, the precise nature of the relationship between erysipelas and gut microbiota remains unclear and subject to debate.

Methods: We conducted a Mendelian Randomization (MR) analysis using publicly available summary data from genome-wide association studies (GWAS) to explore the potential causal relationship between gut microbiota and erysipelas.

Scaffold Adhering to Peptide-Based Biomimetic Extracellular Matrix Composite Nanobioglass Promotes the Proliferation and Migration of Skin Fibroblasts Through the GSK-3β/β-Catenin Signaling Axis.

Introduction: Nano-mesoporous bioactive glass and RGD peptide-coated collagen membranes have great potential in wound healing. However, the application of their compound has not been further studied. Our purpose is to prepare a novel bioactive collagen scaffold containing both NMBG stent and adhesion peptides (BM), which then proves its promising prospect the assessment of physical properties, biocompatibility, GSK-3β/β-catenin signaling axis and toxicological effects.

BODIPY-Based NIR Trackers with Acidity-Driven Amphiphilicity for STED Super-Resolution Imaging of Lysosomal Membranes.

Although super-resolution imaging provides a great opportunity to disclose the structures of living cells at the nanoscale level, resolving the structural details of organelles is highly dependent on the targeting accuracy and photophysical properties of fluorescence trackers. Herein, we report a series of ultrabright and photostable trackers of lysosomal membranes for super-resolution imaging using stimulated emission depletion microscopy (STED). These trackers are composed of lipophilic NIR BODIPY derivatives and ionizable tertiary amines.

Convolutional neural network-based measurement of crown-implant ratio for implant-supported prostheses.

Statement Of Problem: Research has revealed that the crown-implant ratio (CIR) is a critical variable influencing the long-term stability of implant-supported prostheses in the oral cavity. Nevertheless, inefficient manual measurement and varied measurement methods have caused significant inconvenience in both clinical and scientific work.

Purpose: This study aimed to develop an automated system for detecting the CIR of implant-supported prostheses from radiographs, with the objective of enhancing the efficiency of radiograph interpretation for dentists.

Causal effects of gut microbiota on appendicitis: a two-sample Mendelian randomization study.

Background: Previous research has posited a potential correlation between the gut microbiota and the onset of appendicitis; however, the precise causal connection between appendicitis and the gut microbiota remains an unresolved and contentious issue.

Methods: In this investigation, we performed a Mendelian randomization (MR) analysis employing publicly accessible summary data extracted from genome-wide association studies (GWAS) to elucidate the potential causal nexus between the gut microbiota and the development of appendicitis. We initially identified instrumental variables (IVs) through a comprehensive array of screening methodologies, subsequently executing MR analyses using the Inverse Variance Weighted (IVW) technique as our primary approach, supplemented by several alternative methods such as MR Egger, weighted median, simple mode, and weighted mode.

Tetrazine-Based Ratiometric Nitric Oxide Sensor Identifies Endogenous Nitric Oxide in Atherosclerosis Plaques by Riding Macrophages as a Smart Vehicle.

Atherosclerosis (AS) is the formation of plaques in blood vessels, which leads to serious cardiovascular diseases. Current research has disclosed that the formation of AS plaques is highly related to the foaming of macrophages. However, there is a lack of detailed molecular biological mechanisms.

Adoptive macrophage directed photodynamic therapy of multidrug-resistant bacterial infection.

Multidrug-resistant (MDR) bacteria cause severe clinical infections and a high mortality rate of over 40% in patients with immunodeficiencies. Therefore, more effective, broad-spectrum, and accurate treatment for severe cases of infection is urgently needed. Here, we present an adoptive transfer of macrophages loaded with a near-infrared photosensitizer (Lyso700D) in lysosomes to boost innate immunity and capture and eliminate bacteria through a photodynamic effect.

Atmospheric Chemistry of NHSOH in Polluted Areas: An Unexpected Isomerization of NHSOH in Acid-Polluted Regions.

NHSOH is an effective nucleation agent for the formation of atmospheric aerosols and cloud particles. So, the ammonolysis of SO to form NHSOH without and with neutral (HO) and basic (NH) trace gases has been extensively investigated. However, the acidic trace gas X (X = HSO and CHSOH)-assisted ammonolysis of SO is still up for debate.

Engineering Mn-N sites on porous carbon via molecular assembly strategy for long-life zinc-air batteries.

Nitrogen-coordinated manganese atoms on carbon materials denoted as MnNC, serve as the highly active non-precious metal electrocatalysts for oxygen reduction reaction (ORR) in zinc-air batteries (ZABs). Nonetheless, a significant challenge arises from the tendency of Mn atoms to aggregate during heat treatment, thereby compromising ORR performance in ZABs. In this work, the molecular assembly strategy based on the hydrogen bond interaction was employed to fabricate the MnNC electrocatalyst.

Harnessing Machine Learning in Vocal Arts Medicine: A Random Forest Application for "Fach" Classification in Opera.

Vocal arts medicine provides care and prevention strategies for professional voice disorders in performing artists. The issue of correct "Fach" determination depending on the presence of a lyric or dramatic voice structure is of crucial importance for opera singers, as chronic overuse often leads to vocal fold damage. To avoid phonomicrosurgery or prevent a premature career end, our aim is to offer singers an improved, objective fach counseling using digital sound analyses and machine learning procedures.

Integration of Activation by Hypoxia and Inhibition Resistance of Tumor Cells to Apoptosis for Precise and Augmented Photodynamic Therapy.

Photodynamic therapy (PDT) uses photosensitizers to convert oxygen (O ) to reactive oxygen species (ROS) under irradiation to induce DNA damage and kill cancer cells. However, the effect of PDT is usually alleviated by apoptosis resistance mechanism of tumor living cells. MTH1 enzyme is known to be such an apoptosis-resistance enzyme which is over expressed as a scavenger to repair the damaged DNA.