A comprehensive time-series dataset linked to cyanobacterial blooms in Lake Taihu.

Lake Taihu has a history of recurrent harmful cyanobacterial blooms. There is a need to better understand the aquatic ecosystem of Lake Taihu in order to improve methods for controlling the cyanobacterial blooms. Based on the field measurement and satellite remote sensing, we produced and collected a time-series dataset, including the water quality, bio-optics, climate, and anthropogenic data of Lake Taihu (THQBCA), which could provide comprehensive information regarding cyanobacterial blooms.

Correlation between elderly patients with COPD and the impact on immunity in tuberculosis patients: A retrospective study.

The prevalence of chronic obstructive pulmonary disease (COPD) and tuberculosis (TB) is increasing globally, yet their comprehensive impact on the immune system remains underexplored. This study aimed to provide a thorough assessment of the immune status of patients with COPD and tuberculosis (TB-COPD), including their pulmonary conditions, immune cell responses, and changes in lymphocyte subpopulations. A total of 151 patients with TB-COPD patients were included, and clinical data were compared between the TB-COPD group and a group of TB patients without COPD (TB-NCOPD).

Discovery of Preclinical Candidate AD1058 as a Highly Potent, Selective, and Brain-Penetrant ATR Inhibitor for the Treatment of Advanced Malignancies.

The ataxia telangiectasia-mutated and Rad3-related protein (ATR) plays a crucial role in regulating the cellular DNA-damage response (DDR), making it a promising target for antitumor drug development through synthetic lethality. In this study, we present the discovery and detailed characterization of AD1058, a highly potent and selective ATR inhibitor, with good preclinical pharmacokinetic profiles. AD1058 exhibits superior efficacy in inhibiting cell proliferation, disrupting the cell cycle, and inducing apoptosis compared to AZD6738.

A dataset of trophic state index for nation-scale lakes in China from 40-year Landsat observations.

Trophic state index (TSI) serves as a key indicator for quantifying and understanding the lake eutrophication, which has not been fully explored for long-term water quality monitoring, especially for small and medium inland waters. Landsat satellites offer an effective complement to facilitate the temporal and spatial monitoring of multi-scale lakes. Landsat surface reflectance products were utilized to retrieve the annual average TSI for 2693 lakes over 1 km in China from 1984 to 2023.

Prevalence of chronic periodontitis in patients undergoing peritoneal dialysis and its correlation with peritoneal dialysis-related complications.

Objective: The microinflammatory state can influence the occurrence of dialysis-related complications in dialysis patients. Chronic periodontitis (CP), in which plaque biofilm is considered to be the initiating factor, is a chronic infectious disease in the oral cavity. It is still uncertain whether CP affects the microinflammatory state in peritoneal dialysis (PD) and the occurrence of dialysis-related complications.

Determining the effective dose of esketamine for mitigating pain during propofol injection by Dixon's up-and-down method: a double-blind, prospective clinical study of drug dose response.

Background: Propofol is an intravenous (IV) anesthetic medication widely used for procedural sedation, operative anesthesia, and in intensive care unit (ICU), but the incidence of pain during IV infusion can reach 28-90%. Ketamine can attenuate pain associated with IV propofol injection through local and central analgesic effects. Ketamine is gradually being transitioned to its S-enantiomer, esketamine, which has a similar mechanism of action.

Confining Nano-FeO in the Superhydrophilic Membrane Skin Layer to Minimize Internal Fouling.

Membrane surface fouling is often reversible as it can be mitigated by enhancing the crossflow shear force. However, membrane internal fouling is often irreversible and thus more challenging. In this study, we developed a new superhydrophilic poly(vinylidene fluoride) (P-PVDF) membrane confined with nano-FeO in the top skin layer via reverse filtration to reduce internal fouling.

Peritoneal dialysis effluent-derived exosomal miR-432-5p: an assessment tool for peritoneal dialysis efficacy.

Background: Ultrafiltration (UF) volume and peritoneal solute transport rate (PSTR) are common parameters used to evaluate the efficacy of peritoneal dialysis (PD) on individual patients. It is unclear whether the level of exosomal microRNA (miRNA) in peritoneal dialysis effluent (PDE) can predict UF or PSTR. This study was designed to investigate if there is a correlation between PDE exosomal miRNA (miR-432-5p) levels and various UF volumes and PSTRs in PD patients.

The association between self-management ability and malnutrition-inflammation-atherosclerosis syndrome in peritoneal dialysis patients: a cross-sectional study.

Background: The relationship between malnutrition-inflammation-atherosclerosis syndrome (MIAS) and self-management ability has not been previously revealed even though both play an important role in the management of peritoneal dialysis (PD) patients.

Methods: In total, 93 patients were enrolled in this study. A self-management questionnaire was used for the evaluation of self-management ability.

Evaluation of inflammatory and cardiac-electrophysiological markers in patients undergoing peritoneal dialysis.

The Tp-e/QT (peak to end of T-wave duration/QT interval) ratio is a promising marker of myocardial repolarization and ventricular arrhythmogenesis. Its elevation is associated with sudden cardiac death in different clinical conditions. This study was designed to assess the possible association between increased Tp-e/QT ratio and clinical factors in peritoneal dialysis patients.

Separation of Glycolipids/Sphingolipids from Glycerophospholipids on TiO Coating in Aprotic Solvent for Rapid Comprehensive Lipidomic Analysis with Liquid Microjunction Surface Sampling-Mass Spectrometry.

In lipidomic analysis by direct mass spectrometry (MS), high abundance lipids with high ionizability (such as glycerophospholipids) would cause ion suppression to lipids with poor ionizability and low abundance (such as glycolipids, sphingolipids, or glycerides), which largely limits the detection coverage for lipidomics. In this work, TiO-based liquid microjunction surface sampling (LMJSS) coupled with MS was used for separation of glycerides, phospholipids and glycolipids/sphingolipids in biological samples and rapid analysis of lipids in different classes with high lipidome coverage. We found that, in nonaqueous aprotic solvents, lipids with a glycosyl or sphingosine group could be selectively separated from lipids with a phosphate group (selectivity >10) after being coenriched on TiO by tuning the solvent composition.

Absolute quantitative imaging of sphingolipids in brain tissue by exhaustive liquid microjunction surface sampling-liquid chromatography-mass spectrometry.

It is challenging to achieve absolute quantitation and accurate identification with mass spectrometry imaging (MSI) techniques. The issues facing these techniques include the uncertainty of sampling and ionization efficiencies in a localized environment, the difficulty in defining the concentration of spiked standard on tissue, and the low identification capability of MS in distinguishing isobaric compounds. In this study, we coupled continuous flow liquid microjunction surface sampling (LMJSS) with ultrahigh-performance liquid chromatography (UPLC)-MS for quantitative MSI of brain tissue.

[Control efficacy of Trichogramma japonicum against Chilo suppressalis and Chilaraea auricilia].

In order to understand the relationships of the population increase capacities between egg parasitoid Trichogramma japonicum Ashmead (Hymenoptera: Trichogrammatidae) and two rice borers Chilo suppressalis Walker and Chilaraea auricilia Dudgeon (Lepidoptera: Pyralidae), and to evaluate the control efficacy of T. japonicum against C. suppressalis and C.